The Blood-Brain Barrier in Cerebral Amyloidogenesis in Alzheimer’s Disease and Scrapie

  • P. Eikelenboom
  • H. Fraser
  • J. M. Rozemuller
  • F. C. Stam
Conference paper
Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)


There is a diversity of opinions concerning the defect in the blood-brain barrier permeability in Alzheimer’s disease and in scrapie. In this paper we review the evidence for blood-brain barrier dysfunction and for serum factors and blood-borne cells in cerebral amyloidogenesis in Alzheimer’s dementia and in scrapie. The hypothetical role of immunologically mediated injury to the central nervous system in both disorders is discussed. The basis of the different conclusions is identified, and much of the evidence supporting a systematic or haematogeneous origin for cerebral amyloidosis is shown to arise from the unreliability or variation in histochemical techniques, from the inappropriate use of “markers” and from false interpretations based on localisation of proteins and antigens. It is concluded that the primary pathogenesis of plaques occurs within the neuroparenchyma and that the evidence for systemic involvement remains inconclusive.


Amyloid Plaque Senile Plaque Amyloid Fibril Complement Factor Amyloid Plaque Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • P. Eikelenboom
  • H. Fraser
  • J. M. Rozemuller
  • F. C. Stam

There are no affiliations available

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