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Adaptive Supersensitivity

  • Chapter
Catecholamines I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 90 / 1))

Abstract

Over the years, the term supersensitivity has been applied to several phenomena and it was coined long before any of the underlying mechanisms were understood. Given the variety of phenomena to which the term has been applied, Fleming et al. (1973) offered the following definition and explanation of supersensitivity: “Supersensitivity may be defined as the phenomenon in which the amount of a substance required to produce a given biological response is less than ‘normal’, i.e. the dose-response curve is shifted to the left. In a few instances there may also be an increase in the maximum response to a drug. However, this increase in maximal response is not a regular occurrence in supersensitivity. Likewise, supersensitivity may, but need not, be associated with a change in the slope of the dose-response curve. Thus, the one consistent sign of supersensitivity is the shift of the dose-response curve to the left.”

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Authors
  1. W. Fleming
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  2. D. P. Westfall
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-8700, Würzburg, Germany

    U. Trendelenburg (Professor Dr.) (Professor Dr.)

  2. Department of Pharmacology, Colorado University, Medical Center, 4200 East Ninth Street, 802 62, Denver, CO, USA

    N. Weiner (Professor Dr.) (Professor Dr.)

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Fleming, W., Westfall, D.P. (1988). Adaptive Supersensitivity. In: Trendelenburg, U., Weiner, N. (eds) Catecholamines I. Handbook of Experimental Pharmacology, vol 90 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46625-0_9

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