The Interface Between Adenovirus-Transformed Cells and Cellular Immune Response in the Challenged Host

  • A. M. LewisJr.
  • J. L. Cook
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 110)


The discovery by Trentin et al. (1962) that human adenoviruses were capable of producing tumors when inoculated into hamsters created a major role for these agents in the field of viral oncology. As participants in this field, several of the adenovirus (Ad) serotypes are among the most thoroughly studied animal viruses. One of the primary objectives of the study of these agents as tumor viruses has been to elucidate the mechanisms that are associated with their capacity to convert normal cells to neoplastic cells that produce tumors in animals. In approaching this objective, theoretical and technical developments have focused current research on the structure, organization, and expression of the Ad genome, and much has been accomplished. The functional arrangement of the Ad2 genome has been determined and the DNA sequence structure of several Ad serotypes is far advanced. The processing of Ad RNA into cytoplasmic mRNA that is translated into viral proteins has provided new insights into the mechanisms of RNA transcription in eukaryotic organisms. The mode of replication of the Ad genomes is under intensive investigation. The regions of the viral genome that are associated with the conversion of normal cells to neoplastic cells have been located, and many of the proteins encoded by these genes have been identified and in some cases purified. For detailed discussions of these developments, we refer the reader to other chapters in this volume and to recent reviews by Flint (1980a, b), Persson and Philipson (1982), Challberg and Kelly (1982), and Doerfler (1982). In spite of these impressive accomplishments, the goal of defining the mechanism of Ad-induced carcinogenesis has remained elusive, and it is becoming increasingly apparent that the question of how viruses and neoplastic cells produce tumors in animals will most likely remain after understanding of the molecular mechanisms of cell transformation (as defined by the induction of immortality) in vitro has been reached. The complexities of the interactions between cells rendered neoplastic by adenoviruses and the cellular immune defenses of the potential animal host suggest that new concepts and approaches to the possible mechanism of viral carcinogenesis are needed.


Syrian Hamster Adenovirus Type Human Adenovirus Hybrid Cell Line Rodent Cell 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • A. M. LewisJr.
    • 1
  • J. L. Cook
    • 2
  1. 1.Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.Department of MedicineNational Jewish Hospital and Research CenterDenverUSA

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