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Systolic Time Interval Measurements for the Assessment of the Effect of Cardiovascular Drugs

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Systolic Time Intervals

Part of the book series: International Boehringer Mannheim Symposia ((BOEHRINGER))

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Abstract

Systolic time interval (STI) measurements are sensitive indices of myocardial contractility. They reflect a number of factors such as stroke volume, aortic and left ventricular, end-diastolic pressures (1–3) or the level of adrenergic activity (4) which may affect the measured values in opposing directions.

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References

  1. Diament, B., Killip, T.: Indirect assessment of left ventricular performance in acute myocardial infarction. Circulation 42, 579–592 (1970)

    Google Scholar 

  2. Hamosh, P., Cohn, J.M., Engelman, K., Broder, M.I., Freis, E.D.: Systolic time intervals and left ventricular function in acute myocardial infarction. Circulation 45, 375–381 (1972)

    PubMed  CAS  Google Scholar 

  3. Hodges, M., Halpern, B.L., Friesinger, G.C., Degenais, G.R.: Left ventricular pre-ejection period and ejection time in patients with acute myocardial infarction. Circulation 45, 933–942 (1972)

    PubMed  CAS  Google Scholar 

  4. Lewis, R.P., Boudoulas, H., Forester, W.F., Weissler, A.M.: Shortening of electromechanical systole as a manifestation of excessive adrenergic stimulation in acute myocardial infarction. Circulation 46, 856–862 (1972)

    PubMed  CAS  Google Scholar 

  5. Dowling, J.T., Sloman, G., Urquhart, C.: Systolic time interval fluctuations produced by acute myocardial infarction. Br. Heart J. 33, 765–772 (1971)

    Article  PubMed  CAS  Google Scholar 

  6. Martin, C.E., Shaver, J.A., Leonhard, J.J.: Physical signs, apexcardiography, phonocardiography and systolic time intervals in angina pectoris. Circulation 46, 1098–1114 (1972)

    PubMed  CAS  Google Scholar 

  7. Blumberger, K.J.: Der Einfluß der Strophantinbehandlung auf die Anspannungszeit und Austreibungszeit bei herzkranken Menschen. Verh. Dtsch. Ges. Kreislaufforsch. 12, 382–388 (1939)

    Google Scholar 

  8. Weissler, A.M., Gamel, W.G., Grode, H.E., Cohen, S., Schoenfeld, C.D.: Effect of digitalis on ventricular ejection in normal human subjects. Circulation 29, 721–729 (1964)

    PubMed  CAS  Google Scholar 

  9. Weissler, A.B., Snyder, J.R., Schoenfeld, C.D., Cohen, S.: Assay of digitalis glycosides in man. Am. J. Cardiol. 17, 768–780 (1966)

    Article  CAS  Google Scholar 

  10. Matos, L., Békés, M., Polák, G., Rausch, J., Török, E.: Comparative study of the cardiac and peripheral vascular effects of strophanthin K and lanato-side C in coronary heart disease. Eur. J. Clin. Pharmacol. 9, 27–37 (1975)

    Article  PubMed  CAS  Google Scholar 

  11. Weissler, A.M., Harris, W.S., Schoenfeld, C.D.: Bedside techniques for the evaluation of ventricular function in man. Am. J. Cardiol. 23, 577–583 (1969)

    Article  PubMed  CAS  Google Scholar 

  12. Matos, L.: Use of noninvasive methods in the clinical-pharmacological testing of cardiovascular drugs. In: Rationale of drug development. Lucchelli, P.E., Bergamini, N., Bachini, V. (eds.), pp. 127–138. Amsterdam, Oxford: Excerpta Medica 1976

    Google Scholar 

  13. Matos, L., Török, E., Hankóczy, J.: A study of the positive chronotropic and inotropic effect of drugs in symptomatic sinus bradycardia (in Hungarian). Cardiol. Hung. 5, 239–247 (1976)

    Google Scholar 

  14. Matos, L.: Nichtinvasive kardiologische Untersuchungsmethoden. In: Methoden der klinischen Pharmakologie. Kuemmerle, H.-P. (ed.), pp. 321–405. München, Wien, Baltimore: Urban und Schwarzenberg 1978

    Google Scholar 

  15. Matos, L., Istvánffy, M., Halmágyi, R.M., Török, E., Gábor, G.: Circulatory effects of tazolol (RS-6245) in patients with coronary heart disease and hyperkinetic heart syndrome, p. 442. In: Abstracts, 6th Int. Congr. Pharm., Helsinki 1975, Finnish Pharmacological Society, Helsiniki, 1975

    Google Scholar 

  16. Matos, L., Hankóczy, J., Török, E.: Effects of lidocaine on myocardial function and on isopraline-induced circulatory changes in man. Int. J. Clin. Pharmacol. Biopharm. 14, 119–125 (1976)

    PubMed  CAS  Google Scholar 

  17. Boudoulas, H., Schaal, S.F., Lewis, R.P., Welch, T.G., DeGreen, P., Kates, R.W.: Negative inotropic effect of lidocaine in patients with coronary arterial disease and normal subjects. Chest 71, 170–175 (1977)

    Article  PubMed  CAS  Google Scholar 

  18. Weissler, A.M., Kamen, A.H., Bornstein, R.S., Schoenfeld, C.D., Cohen, S.: Effect of deslanoside on the duration of the phases of ventricular systole in man. Am. J. Cardiol. 15, 153–161 (1965)

    Article  PubMed  CAS  Google Scholar 

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© 1980 Springer-Verlag Berlin Heidelberg

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Matos, L. (1980). Systolic Time Interval Measurements for the Assessment of the Effect of Cardiovascular Drugs. In: List, W., Gravenstein, J.S., Spodick, D.H. (eds) Systolic Time Intervals. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46418-8_37

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  • DOI: https://doi.org/10.1007/978-3-642-46418-8_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09871-3

  • Online ISBN: 978-3-642-46418-8

  • eBook Packages: Springer Book Archive

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