The Vinca Alkaloids

  • W. A. Creasey
Part of the Antibiotics book series (ANTIBIOTICS, volume 5 / 2)


The vinca alkaloids are antineoplastic indole derivatives (Fig. 1) that are isolated from the leaves of the periwinkle plant, Vinca rosea L., or more correctly, Catharanthus roseus G. Don. This plant is of Madagascan origin, although its distribution is now pantropical (Stearn, 1975). Even in varieties selected for the highest alkaloid content, the concentrations of these antitumor agents are very low, as much as 1 kg of dried leaves being needed to obtain 3 mg of vincristine, for example.


Vinca Alkaloid Mitotic Arrest Catharanthus Roseus Ehrlich Ascites Carcinoma Cell Microtubule System 
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© Springer-Verlag Berlin · Heidelberg 1979

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  • W. A. Creasey

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