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Antitumor Platinum Compounds

  • Chapter
Mechanism of Action of Antieukaryotic and Antiviral Compounds

Part of the book series: Antibiotics ((1512,volume 5 / 2))

Abstract

As a consequence of a classic case of serendipity in science a range of platinum coordination complexes were demonstrated to have potent antitumor action against Sarcoma 180 and Leukemia L1210 (Rosenberg et al., 1969; Rosenberg and van Camp, 1970), a viral-induced reticulum cell sarcoma in mice (Talley, 1970), the Dunning ascitic leukemia, Walker 256 carcinosarcoma (Kociba et al., 1970),and a DMBA-induced mammary carcinoma (Welsh, 1971) in rats.

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  1. Department of the Army, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C., 20012, USA

    Fred E. Hahn Ph.D.

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Roberts, J.J. (1979). Antitumor Platinum Compounds. In: Hahn, F.E. (eds) Mechanism of Action of Antieukaryotic and Antiviral Compounds. Antibiotics, vol 5 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46407-2_2

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