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5-Iodo-2′-Deoxyuridine

  • W. H. Prusoff
  • M. S. Chen
  • P. H. Fischer
  • T. S. Lin
  • G. T. Shiau
Part of the Antibiotics book series (ANTIBIOTICS, volume 5 / 2)

Abstract

Iodinated pyrimidines were first synthesized by Johnson and Johns (1905–1906), and a systematic study of the biologic activities of various purine and pyrimidine base analogs was initiated by Hitchings et al. (1945) and extended by Thompson et al. (1949). The clinical potential of base analogs, whether halogenated or not, has been well recognized in chemotherapy. Furthermore, such compounds have proven to be powerful tools for elucidation of many intricate biochemical events of importance to molecular biology. Halogenated pyrimidine bases (ClUra, BrUra, IUra) are readily incorporated into the DNA of various microorganisms, however they are poorly utilized for the biosynthesis of DNA in mammalian systems in contrast to the corresponding deoxyribonucleosides (CldUrd, BrdUrd, IdUrd).

Keywords

Herpes Simplex Antiviral Activity Herpes Simplex Virus Type Herpes Zoster Vaccinia Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin · Heidelberg 1979

Authors and Affiliations

  • W. H. Prusoff
  • M. S. Chen
  • P. H. Fischer
  • T. S. Lin
  • G. T. Shiau

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