Skip to main content

Routes of Administration and Drug Response

  • Chapter
Concepts in Biochemical Pharmacology

Abstract

The route of administration for a drug should be selected to achieve an effective concentration at the site of action as conveniently as possible. Important subsidiary objectives may be rapidity of onset and duration of drug effect and, in some instances, selectivity of action.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bass, M.: Sudden sniffing death. J. Amer. med. Ass. 212, 2075–2079 (1970).

    Article  CAS  Google Scholar 

  • Beckett, A.H., Hossie, R.D.: Buccal absorption of drugs, pp. 25–45. In: Brodie, B.B., Gillette, J.R. (Eds.): Concepts in biochemical pharmacology, Part I. Berlin-Heidelberg-New York: Springer 1971.

    Google Scholar 

  • Bianchine, J.R., Calimlim, L.R., Morgan, J.P., Dujuvne, C.A., Lasagna, L.: Metabolism and absorption of L-3, 4 dihydroxyphenylalanine in patients with Parkinson’s disease. Ann. N. Y. Acad. Sci. 179, 126–140 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Boyes, R.N., Adams, H. J., Duce, B.P.: Oral absorption and disposition kinetics of lidocaine hydrochloride in dogs. J. Pharmacol, exp. Ther. 174, 1–8 (1970).

    CAS  Google Scholar 

  • Boyes, R.N., Keenaghan, J.B.: Some aspects of the metabolism and distribution of lidocaine in rats, dogs and man. In: Scott, D.B., Julian, D.G. (Eds.): Lidocaine in the treatment of ventricular arrhythmias, pp. 140–151. Edinburgh: Livingston 1971.

    Google Scholar 

  • Boyes, R.N., Scott, D.B., Jebson, P.J., Goodman, M. J., Julian, D.G.: Pharmacokinetics of lidocaine in man. Clin. Pharm. Therap. 12, 105–116 (1971).

    PubMed  CAS  Google Scholar 

  • Brazeau, P.: Inhibitors of tubular transport of organic compounds. In: Goodman, L.S., Gilman, A. (Eds.): The pharmacological basis of therapeutics, p. 897. New York: MacMillan 1970a.

    Google Scholar 

  • Brazeau, P.: Agents affecting the renal conservation of water. In: Goodman, S., Gilman, A. (Eds.): The pharmacological basis of therapeutics, p. 881. New York: MacMillan 1970b.

    Google Scholar 

  • Brodie, B.B., Lowman, E.W., Burns, J.J., Lee, P.R., Cherkin, T., Goldman, A., Weiner, M., Steele, J.M.: Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone. Amer. J. Med. 16, 181–190 (1954).

    Article  PubMed  CAS  Google Scholar 

  • Burchell, H.B.: Clinical problems related to surgical repair of intracardiac defects with the aid of an extracorporeal pump-oxygenator. Circulation 16, 976–987 (1957).

    PubMed  CAS  Google Scholar 

  • Butler, J.: Percutaneous absorption of tritium-labelled Betamethazone-17-valerate. Brit. J. Derm. 78, 665–668 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Coltart, D. J., Shand, D.G.: Plasma propranolol levels in the quantitative assessment of B-adrenergic blockade in man. Brit. med. J. 1970 III, 731–734.

    Article  Google Scholar 

  • Conolly, M.E., Davies, D.S., Dollery, C.T., Morgan, C.D., Paterson, J.W., Sandler, M.: Metabolism of isoprenaline in dog and man. Brit. J. Pharmacol. In press (1972).

    Google Scholar 

  • Curry, S.H.: Chlorpromazine: Concentrations in plasma, excretion in urine and duration of effect. Proc. roy. Soc. Med. 64, 285–289 (1971).

    PubMed  CAS  Google Scholar 

  • Curry, S.H., D’Mello, A., Mould, G.P.: Destruction of chlorpromazine during absorption in the rat in vivo and in vitro. Brit. J. Pharmacol. 42, 403–411 (1971).

    CAS  Google Scholar 

  • Curry, S.H.: Action and metabolism of chlorpromazine. In: Davies, D.S., Prichard, B.N.C. (Eds.): Biological effects of drugs in relation to their plasma concentrations. London: MacMillan in press (1972).

    Google Scholar 

  • Davidson, I. W. F., Rollins, F. O., Di Carlo, F. J., Miller, H. S., Jr.: The pharmacodynamics and biotransformation of penta-erythritol trinitrate in man. Clin. Pharmacol. 12, 972–981 (1971).

    CAS  Google Scholar 

  • Dollery, C.T.: Absorption, distribution and excretion of drugs used to treat hypertension. In: Binns, T. B. (Ed.): Absorption and distribution of drugs, p. 157. Edinburgh: Livingston 1964.

    Google Scholar 

  • Dollery, C.T., Davies, D.S., Conolly, M.E.: Differences in the metabolism of drugs depending on their routes of administration. Ann. N. Y. Acad. Sci. 179, 108–114 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Eger, E.I.II., Larson, O.P., Jr.: Anaesthetic solubility in blood and tissues: values and significance. Brit. J. Anaesth. 36, 140–149 (1964).

    Article  PubMed  Google Scholar 

  • Ellard, G. A., Garrod, J.M.B., Scales, B., Snow, G.A.: Percutaneous absorption and routes of excretion of ditophal (Etisul). Biochem. Pharmacol. 12, 271–281 (1963).

    Article  Google Scholar 

  • Enna, S.J., Shanker, L.S.: Drug absorption from the lung. Fed. Proc. Fed. Amer. Soc. exp. Biol. 28, 359 (1969).

    Google Scholar 

  • Franch, R.H.: Cardiac catheterization. In: Hurst, J.W., Logue, R.B. (Eds.): The heart, pp. 164–192. New York: McGraw-Hill 1966.

    Google Scholar 

  • Harrison, D.C.: In: Scott, D.B., Julian, D.G. (Eds.): Lidocaine in the treatment of ventricular arrhythmias, p. 166. Edinburgh: Livingston 1971.

    Google Scholar 

  • Hayes, A., Cooper, R.G.: Studies on the absorption, distribution and excretion of propranolol in rat, dog and monkey. J. Pharmacol, exp. Ther. 176, 302–311 (1971).

    CAS  Google Scholar 

  • Herbert, V.: Drugs effective in megaloblastic anaemias. In: Goodman, L. S., Gdlman, A. (Eds.): The pharmacological basis of therapeutics, p. 1429, 4th ed. New York: MacMillan 1970.

    Google Scholar 

  • Hollister, L.E., Curry, S.H., Derr, J.E., Kanter, S.L.: Studies of delayed-action medication: V. plasma levels and urinary excretion of four different dosage forms of chlor-promazine. Clin. Pharmacol. Ther. 11, 49–59 (1970).

    PubMed  CAS  Google Scholar 

  • James, V.H.T., Munro, D.D., Feiwel, M.: Pituitary-adrenal function after occlusive topical therapy with Betamethasone-11-valerate. Lancet 1967 II, 1059–1061.

    Article  Google Scholar 

  • Jewitt, D.E., Kishon, Y., Thomas, M.: Lignocaine in the management of arrhythmias after acute myocardial infarction. Lancet 1968 I, 266–270.

    Article  Google Scholar 

  • Jones, R. J.: Medical control of Adams-Stokes syndrome. J. Amer. med. Ass. 167, 1840–1842 (1958).

    Article  CAS  Google Scholar 

  • Katz, M., Poulsen, B. J.: Absorption of drugs through the skin. In: Brodle, B.B., Gillette, J.R. (Eds.): Concepts in biochemical pharmacology, Part I, pp. 103–162. Berlin-Heidelberg-New York: Springer 1971.

    Google Scholar 

  • Levy, G.: Kinetics and implications of dissolution-rate-limited gastrointestinal absorption of drugs. In: Arins, E. J. (Ed.): Physicochemical aspects of drug actions. Proceedings of the third International Pharmacological Meeting, Vol. 7, pp. 33–62. Oxford: Pergamon 1968.

    Google Scholar 

  • McCarthy, C.G., Finland, M.: Absorption and excretion of four penicillins. New Engl. J. Med. 263, 315–326 (1960).

    Article  Google Scholar 

  • McDermott, W., Bunn, P.A., Benoit, M., Dubois, R., Reynolds, M.E.: The absorption, excretion and destruction of orally administered penicillin. J. clin. Invest. 25, 190–210 (1946).

    Article  Google Scholar 

  • Minatoya, H., Lands, A.M., Portmann, G.A.: Absorption and elimination profile of isoproterenol. I. J. Pharm. Sci. 54, 968–972 (1965).

    Article  CAS  Google Scholar 

  • Mroczek, W.J., Leibel, B.A., Davidov, M., Finnerty, F.A.: The importance of the rapid administration of diazoxide in accelerated hypertension. New Engl. J. Med. 285, 603–606 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Papper, E.M.: The pharmacokinetics of inhalation anaesthetics: clinical application. Brit. J. Anaesth. 36, 124–128 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Paterson, J.W., Conolly, M.E., Davies, D.S., Dollery, C.T.: Isoprenaline resistance and the use of pressurised aerosols in asthma. Lancet 1968 II, 426–429.

    Article  Google Scholar 

  • Paterson, J.W., Conolly, M.E., Dollery, C.T., Hayes, A., Cooper, R.G.: The pharmacodynamics and metabolism of propranolol in man. Pharmacologia Clinica 2, 127–133 (1970).

    Article  CAS  Google Scholar 

  • Portmann, G.A., Minatoya, H., Lands, A.M.: Absorption and elimination profile of isoproterenol. II. J. Pharm. Sci. 54, 973–978 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Price, H. L.: A dynamic concept of the distribution of thiopental in the human body. Anesthesiology 21, 40–45 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Rowland, M., Thomson, P.D., Guichard, A., Melmon, K.L.: Disposition kinetics of lidocaine in normal subjects. Ann. N. Y. Acad. Sci. 179, 383–399 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Schou, J.: Subcutaneous and intramuscular injection of drugs. In: Brodle, B.B., Gillette, J.R. (Eds.): Concepts in biochemical pharmacology, Part I, pp. 47–63. Berlin-Heidelberg-New York: Springer 1971.

    Google Scholar 

  • Schumacher, E.E. Jr., Schmock, C.L.: The control of certain cardiac arrhythmias with iso-propylnorepinephrine. Amer. Heart J. 48, 933–940 (1954).

    Article  PubMed  Google Scholar 

  • Sellers, E. M., Koch-Weser, J.: Protein binding and vascular activity of diazoxide. New Engl. J. Med. 281, 1141–1145 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Shand, D.G., Evans, G.H., Nies, A. S.: The almost complete hepatic extraction of propranolol during intravenous administration in the dog. Life Sci. Part I 10, 1417–1421 (1971).

    CAS  Google Scholar 

  • Shanker, L.S.: Absorption of drugs from the gastro-intestinal tract. In: Brodie, B.B., Gillette, J.R. (Eds.): Concepts in biochemical pharmacology Part I, pp. 9–23. Berlin-Heidelberg-New York: Springer 1971.

    Google Scholar 

  • Speizer, P.E., Doll, R., Heaf, P.: Investigation into use of drugs preceding death from asthma. Brit. med. J. 1, 339–343 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Stenson, R.E., Constantino, R. T., Harrison, D.C.: Interrelationships of hepatic blood flow, cardiac output, and blood levels of lidocaine in man. Circulation 43, 205–211 (1971).

    PubMed  CAS  Google Scholar 

  • Thomson, P.D., Rowland, M., Melmon, K.L.: The influence of heart failure, liver disease, and renal failure on the disposition of lidocaine in man. Amer. Heart J. 82, 417–421 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Walker, S.R., Evans, M.E., Richards, A.J., Paterson, J.W.: The fate of 14C disodium cromoglycate in man. J. Pharm. Pharmacol. In press (1972).

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1975 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Dollery, C.T., Davies, D.S. (1975). Routes of Administration and Drug Response. In: Gillette, J.R., Mitchell, J.R. (eds) Concepts in Biochemical Pharmacology. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 28 / 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46314-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-46314-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46316-7

  • Online ISBN: 978-3-642-46314-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics