Abstract
Kinins influence mammalian lungs both directly and indirectly. In several species, kinins lessen the volume of air entering the lungs during spontaneous or artificial ventilation in vivo and, in the guinea pig, they are also effective in isolated preparations of lungs or tracheobronchial muscle. In some species also, kinins raise the pressure in the pulmonary artery and constrict isolated pulmonary blood vessels. Kinins affect, too, the rate and depth of the ventilatory movements of ribs and diaphragm.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aarsen, P. N.: The influence of analgesic antipyretic drugs on the responses of guinea-pig lungs to bradykinin. Brit. J. Pharmacol. 27, 196–204 (1966).
Abe, K., Watanabe, N., Kuit Gai, N., Mouri, T., Seri, T., Yoshinaga, K.: Cicurlating plasma kinin in patients with bronchial asthma. Experientia (Basel) 23, 626 (1967).
Berry, P. A.: Slow-reacting substance in anaphylaxis (SRS-A), its release, actions and antagonism. Ph.D. Thesis. Council of National Academic Awards, London, p. 91–93 (1966).
Berry, P. A. Collier, H. O. J.: Bronchoconstrictor action and antagonism of a slow-reacting substance from anaphylaxis of guinea-pig lung. Brit. J. Pharmacol. 23, 201–216 (1964).
Bhoola, K. D., Collier, H. O. J., Schachter, M., Shorley, P. G.: Action of some peptides on bronchial muscle. Brit. J. Pharmacol. 19, 190–197 (1962).
Bisset, G. W., Lewis, G. P.: A spectrum of pharmacological activity in some biologically active peptides. Brit. J. Pharmacol. 19, 168–182 (1962).
Brocklehurst, W. E., Lahiri, S. C.: The production of bradykinin in anaphylaxis. J. Physiol. (Lond.) 160, 15–16P (1962).
Brocklehurst, W. E., Lahiri, S. C.: Formation and destruction of bradykinin during anaphylaxis. J. Physiol. (Lond.) 165, 39–40P (1963).
Carpi, A., Klurp, H., Konzett, H.: Ãœber die Bradykinin-Wirkung am Herz-LungenPriiparat des Meerschweinchens. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 243, 356 (1962).
Collier, H. O. J.: Some pharmacological correlates of anti-inflammatory activity. A study of nonsteroidal anti-inflammatory drugs as antagonists of local hormones. In: Non-steroidal anti-inflammatory drugs, p. 139–150, ed. by S. Garattini, and N. M. G. DUKES. Amsterdam: Excerpta Medica 1965.
Collier, H. O. J.: Self-antagonism of bronchoconstriction induced by bradykinin and angiotensin. In: Hypotensive peptides, p. 305–313, ed. by E. G. Erdös, N. Back, and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.
Collier, H. O. J.: A pharmacological analysis of aspirin. Advanc. Pharmacol., 7, 333–405 (1969).
Collier, H. O. J., Hammond, A. R., Whiteley, B.: Anti-anaphylactic action of acetylsalicylate in guinea-pig lung. Nature (Lond.) 200, 176–178 (1963).
Collier, H. O. J., Holgate, J. A., Schachter, M., Shorley, P. G.: An apparent bronchoconstrictor action of bradykinin and its suppression by some anti-inflammatory agents. J. Physiol. (Lond.) 149, 54–55P (1959).
Collier, H. O. J., Holgate, J. A., The bronchoconstrictor action of bradykinin in the guinea-pig. Brit. J. Pharmacol. 15, 290–297 (1960).
James, G. W. L.: Humoral factors affecting pulmonary inflation during acute anaphylaxis in the guinea-pig. Brit. J. Pharmacol. 30, 283–301 (1967).
James, G. W. L.: Humoral factors in airway function, with particular reference to anaphylaxis in the guinea-pig. In: The physiology and pharmacology of the airways, ed. by A. BouuUYs. Springfield, Ill.: Thomas 1969.
James, G. W. L., Piper, P. J.: Intensification by adrenalectomy or by ß-adrenergic blockade of the bronchoconstrictor action of bradykinin in the guinea-pig. J. Physiol. (Lond.) 180, 13–14P (1965).
James, G. W. L., Piper, P. J.: Antagonism by fenamates and like-acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea-pig. Brit. J. Pharmacol. 34, 76–87 (1968).
James, G. W. L., Piper, P. J., Schneider, C.: Antagonism by aspirin and fenamates of bronchoconstriction and nociception induced by adenosine-5’-triphosphate. Nature (Lond.) 212, 411–412 (1966).
Shorley, P. G.: Analgesic antipyretic drugs as antagonists of bradykinin. Brit. J. Pharmacol. 15, 601–610 (1960).
Shorley, P. G.: Antagonism by mefenamic and flufenamic acids of the bronchoconstrictor action of kinins in the guinea-pig. Brit. J. Pharmacol. 20, 345–351 (1963).
Comune, R. S., Silver, M., Sinclair, D. G.: The effects of bradykinin, angiotensin and acetylcholine on the bovine adrenal medulla. J. Physiol. (Lond.) 196, 339–350 (1968).
Di Mattel, P.: Occurrence of bradykinin in human pulmonary carcinoma. Biochem. Pharma
col. 16 909–911 (1967).
Dolovioh, J., Back, N., Arbesman, C. E.: The presence of bradykinin-like activity in nasal secretions from allergic subjects. J. Allergy (Abstr.) 41, 103 (1968).
Elliott, D. F., Horton, E. W., Lewis, G. P.: Actions of pure bradykinin. J. Physiol. (Lond.) 153, 473–480 (1960).
Erdös, E. G.: Hypotensive peptides. Bradykinin, kallidin and eledoisin. Advanc. Pharmacol. 4, 1–90 (1966).
Feldberg, W., Lewis, G. P.: The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin. J. Physiol. (Lond.) 171, 98–108 (1964).
Ferreira, S. H., Vane, J. R.: The disappearance of bradykinin and eledoisin in the circulation and vascular beds of the cat. Brit. J. Pharmacol. 30, 417–424 (1967).
Girard, J. P., Moret, P.: Action de la sérotonine et de la bradykinine en aérosols chezles asthmatiques. Helv. med. Acta 30, 520–526 (1963).
Gaurls, V., Heicke, B., Westermann, E.: Über die Stimulierung der Atmung durch Bradykinin und Kallidin. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 247, 429–444 (1964a).
Gaurls, V., Heicke, B., Westermann, E.: Apnoe nach Bradykinin und Kallidin. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 248, 540–551 (1964b).
Gaurls, V., Westermann, E.: Bronchoconstrictor action of bradykinin, kallidin and eledoisin. Nature (Lund.) 205, 402–404 (1965).
Greeff, K., Moog, E.: Vergleichende Untersuchungen über die bronchoconstrictorische und gefäßconstrictorische Wirkung des Bradykinins, Histamins und Serotonins an isolierten Lungenpräparaten. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 248, 204–215 (1964).
Greeff, K., Scharnagel, K., Lünn, R., Strobach, H.: Die Abnahme des Kininogengehaltes des Plasmas beim toxischen, anaphylaktischen und anaphylaktoiden Schock. Naunyn Schmiedebergs Arch. exp. Path. Pharmak. 253, 235–245 (1966).
Green, M.: How big are the bronchioles ? St Thom. Hosp. Gaz. 63, 136–139 (1966).
Hauge, A., Lunde, P. K. M., Waaler, B. A.: The effect of bradykinin, kallidin and eledoisin upon the pulmonary vascular bed of an isolated blood-perfused rabbit lung preparation. Acta physiol. scand. 66, 269–277 (1966).
Hawkins, D. F.: Pharmacological studies of bronchial and intestinal muscle in relation to anaphylaxis and asthma. Ph.D. Thesis, University of London, p. 250–251, 367; 1952.
Herxheimer, H, Stresemann, E.: The effect of bradykinin aerosol in guinea-pigs and in man. J. Physiol. (Lond.) 158, 38–39P (1961).
Herxheimer, H, Stresemann, E.: Bradykinin and ethanol in bronchial asthma. Arch. int. Pharmacodyn. 144, 315–318 (1963).
Janküt., E. O., Virtama P.: Bronchographic demonstration of the bronchoconstrictor
effect of bradykinin in the guinea-pig. Ann. Med. exp. Fenn. 41, 436–440 (1963).
Jahn, U., Wagner-Jauregg T.: Vergleich von zwei neuen Klassen antiphlogistischer
Substanzen im Collier-Test. Arzneimittel-Forsch. 18, 120–121 (1968).
James, G. W. L.: The use of the in vivotrachea preparation of the guinea-pig to assessdrug action on lung. J. Pharm. Pharmacol. 21, 379–386 (1969).
Jonasson, O., Becker, E. L.: Release of kallikrein from guinea pig lung during anaphylaxis. J. exp. Med. 123, 509–522 (1966).
Konzett, H., Rössler, R.: Versuchsanordnung zu Untersuchungen an der Bronchial muskulatur. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 195, 71–74 (1940).
Konzett, H., STÃœRmer, E.: Biological activity of synthetic polypeptides with bradykinin-like properties. Brit. J. Pharmacol. 15, 544 551 (1960).
Lahiri, S C: The activation of kinins by antigen-antibody reactions. Ph.D. Thesis. Edinburgh University, p. 66–87, 1962.
Lecomte, J., Petit, J. M., MÉLon, J., Troquet, J., Marcelle, R.: Propriétés bronchoconstrictrices de la bradykinine chez l’homme asthmatique. Arch. int. Pharmacodyn. 137, 232–235 (1962).
Lecomte, J., Troquet, J., Cession-Fosslon, A.: Sur la nature de l’hypertension artérielle provoquée par la bradykinine et la kallidine. Arch. int. Pharmacodyn. 147, 518–524 (1964).
Lecomte, J., Troquet, J., Dresse, A.: Stimulation médullo-surrénalienne par la bradykinine. Arch. int. Physiol. 69, 89–91 (1961).
Lewis, G. P.: Kinin antagonism and kinin formation. In: Salicylates: An International Symposium, p. 134–137, ed. by A. ST. J. Dixon, B. K. Martin, M. J. H. Smith, and P. N. H. Wood. London: Churchill 1963.
Lewis, G. P., Reit, E.: The action of angiotensin and bradykinin on the superior cervical ganglion of the cat. J. Physiol. (Lond.) 179, 538–553 (1965).
Lewis, G. P., Reit, E.: Further studies on the actions of peptides on the superior cervical ganglion and suprarenal medulla. Brit. J. Pharmacol. 26, 444 460 (1966).
Marquardt, H.: Zur Frage der Entstehung der vagal-reflektorischen Bradykinin-Tachypnoe. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 253, 207–220 (1966).
Moog, E., Greeff, K.: Der Einfluß verschiedener biogener Amine und Polypeptide auf die Gefäß-und Bronchialmuskulatur isoliert durchströmter Meerschweinchenlungen. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 246, 16–17 (1963).
Piper, P. J., Collier, H. O. J., Vane, J. R.: Release of catecholamines in the guinea-pig by substances involved in anaphylaxis. Nature (Lond.) 213, 838–840 (1967).
Piper, P. J., Vane, J. R.: The assay of catecholamines released into the circulation of the guinea-pig by angiotensin. J. Physiol. (Lond.) 188, 20–21P (1967).
Rosenthale, M. E., Dexvinis, A., Begany, A. J., Lapidus, M., Gluckman, M. I.: Bronchodilator activity of the prostaglandin PGE2. Pharmacologist 10, 175 (1968).
Smixz, J., Graeme, M. L., Sigg, E. B.: Bradykinin induced bronchoconstriction in guinea-pigs and its modification by various agents. Arch. int. Pharmacodyn. 165, 291–301 (1967).
Staszewska-Barczak, J., Vane, J. R.: The release of catecholamines from the adrenal medulla by peptides. Brit. J. Pharmacol. 30, 655–667 (1967).
Stresemann, E.: Die Wirkung von Bradykinin-Aerosol auf die Atmung des Menschen und des Meerschweinchens und der Einfluß verschiedener Substanzen auf den experimentellen Bradykinin-Bronchospasmus. Acta allerg. (Kbh.) 18, 235–255 (1963).
Stürmer, E., Berde, B.: A comparative pharmacological study of synthetic eledoisin and synthetic bradykinin J Pharmacol. exp. Ther. 140, 349–355 (1963).
Trendelenburg, U.: Observations on the ganglion-stimulating action of angiotensin and bradykinin J Pharmacol. exp. Ther. 154, 418–425 (1966).
Varonier, H. S., Panzani, R.: The effect of inhalation of bradykinin on healthy and atopic (asthmatic) children. Int. Arch. Allergy 34, 293–296 (1968).
Waaler, B. A.: The effect of bradykinin in an isolated perfused dog lung preparation. J. Physiol. (Lond.) 157, 475–483 (1961).
Weibel, E. R.: Morphometry of the human lung, p. 110–143. Berlin-Göttingen-Heidelberg: Springer 1963.
Widdicombe, J. G.: Regulation of tracheobronchial smooth muscle. Physiol. Rev. 43, 1–37 (1963).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1970 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Collier, H.O.J. (1970). Kinins and Ventilation of the Lungs. In: Erdös, E.G., Wilde, A.F. (eds) Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 25 / 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46222-1_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-46222-1_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-46224-5
Online ISBN: 978-3-642-46222-1
eBook Packages: Springer Book Archive