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Enzymatic Reduction of Ribonucleotides in Escherichia coli

  • Agne Larsson
Conference paper

Abstract

The fundamental role of deoxyribonucleotides as precursors in the cellular synthesis of DNA has prompted an extensive investigation of the biochemical processes involved in their formation. Tracer experiments performed in vivo have established that in Escherichia coli — as in several bacterial and animal cells — deoxyribonucleotides are synthesized exclusively by reduction of the corresponding ribonucleotides (cf. [1]). In vivo experiments have also demonstrated that in the cell the conversion of a ribosyl to a deoxyribosyl compound is an irreversible process.

Keywords

Nucleoside Triphosphate Enzymatic Reduction Sucrose Gradient Centrifugation Allosteric Effector Reductase System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1969

Authors and Affiliations

  • Agne Larsson
    • 1
  1. 1.Department of Chemistry IIKarolinska InstitutetStockholmSweden

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