Enzymatic Reduction of Ribonucleotides in Escherichia coli

  • Agne Larsson
Conference paper


The fundamental role of deoxyribonucleotides as precursors in the cellular synthesis of DNA has prompted an extensive investigation of the biochemical processes involved in their formation. Tracer experiments performed in vivo have established that in Escherichia coli — as in several bacterial and animal cells — deoxyribonucleotides are synthesized exclusively by reduction of the corresponding ribonucleotides (cf. [1]). In vivo experiments have also demonstrated that in the cell the conversion of a ribosyl to a deoxyribosyl compound is an irreversible process.


Nucleoside Triphosphate Enzymatic Reduction Sucrose Gradient Centrifugation Allosteric Effector Reductase System 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1969

Authors and Affiliations

  • Agne Larsson
    • 1
  1. 1.Department of Chemistry IIKarolinska InstitutetStockholmSweden

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