Clinical Application of Xylitol in Diabetes

  • Shoichi Yamagata
  • Yoshio Goto
  • Akira Ohneda
  • Moritoshi Anzai
  • Satoshi Kawashima
  • Jin Kikuchi
  • Mamoru Chiba
  • Yoshisuke Maruhama
  • Yuichi Yamauchi
  • Takayoshi Toyota

Abstract

As a result of the pioneering experiments of Dr. Lang and his coworkers [1], and the subsequent clinical investigations of Prellwitz and Bassler [2], andMehnert, Summa, and Forster [3], it became apparent that the disappearance of intravenously administered xylitol was essentially the same in normal and diabetic subjects. The production of xylitol in large quantities since 1964, made it possible to explore the use of this pentitol in clinical conditions, particularly diabetes mellitus, in which animal studies suggested a possible beneficial effect.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kieckebuch, W., W. Griem, K. Lang: Klin. Wschr. 39, 447 (1961).PubMedCrossRefGoogle Scholar
  2. 2.
    Prellwitz, W., K. H. Bassler: Klin. Wschr. 41, 196 (1963).PubMedCrossRefGoogle Scholar
  3. 3.
    Mehnert, H., J. D. Summa, H. Forster: Klin. Wschr. 42, 382 (1964).PubMedCrossRefGoogle Scholar
  4. 4.
    Yamagata, S., Y. Goto, A. Ohneda, M. Anzai, S. Kawashima, M. Chiba, Y. Maruhama, Y. Yamauchi: Lancet 1965 II, 918.Google Scholar
  5. 5.
    Kusumoto, T., Y. Ohnishi, T. Takano, H. Kono, T. Yamabuki:Tonyobyo (J. Jap. Diab. Soc.) 8, 107 (1965).Google Scholar
  6. 6.
    Horiuchi, A., K. Tanaka, S. Kitamura, Y. Niki, H. Kawara: Tonyobyo 9, 266 (1966).Google Scholar
  7. 7.
    Yoshitoshi, Y., T. Kaneko: Shinryo 20, 597 (1967).Google Scholar
  8. 8.
    Ishii, H., N. Takahashi, M. Oda, T. Shishido, M. Tsuchiya, K.Sambe: Tonyobyo 11, 36 (1968).Google Scholar
  9. 9.
    Masuda, M., K. Kuzuya, K. Mori, J. Irino, S. Tomikawa, C. Nakano, T. Kanetsuna: Tonyobyo 8, 107 (1965).Google Scholar
  10. 10.
    Fujisawa, M., Y. Hirata: Tonyobyo 9, 131 (1966).Google Scholar
  11. 11.
    Bassler, K. EL, G. Dreiss: Klin. Wschr. 41, 593 (1963).PubMedCrossRefGoogle Scholar
  12. 12.
    Fukui, S., T. Tsujii, Y. Fukuoka, M. Tamura, S. Sato, Y. Matsuoka, O. Makiura, Y. Funada, J. Sakamoto, S. Fukuda: J. Jap. Soc. Int. Med. 56, 805 (1967).Google Scholar
  13. 13.
    Fukiyama, K., S. Fujisawa, Y. Hirata: Naika 16, 587 (1965).PubMedGoogle Scholar
  14. 14.
    Akazawa, Y., T. Iehara, H. Mori, B. Hashimoto, T. Tanaka: Iryo 21, 891 (1967).PubMedGoogle Scholar
  15. 15.
    Mellinghoff, C. H.: Klin. Wschr. 39, 447 (1961).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1969

Authors and Affiliations

  • Shoichi Yamagata
    • 1
  • Yoshio Goto
    • 1
  • Akira Ohneda
    • 1
  • Moritoshi Anzai
    • 1
  • Satoshi Kawashima
    • 1
  • Jin Kikuchi
    • 1
  • Mamoru Chiba
    • 1
  • Yoshisuke Maruhama
    • 1
  • Yuichi Yamauchi
    • 1
  • Takayoshi Toyota
    • 1
  1. 1.Department of Internal MedicineTohoku University School of MedicineSendaiJapan

Personalised recommendations