The Influence of Xylitol and other Polyols and Sugars on Fat Mobilization

  • Klaus Opitz


The so-called non-esterified or free fatty acids (NEFA, FFA) constitute a small but very dynamic plasma lipid fraction. These FFA are important sources of energy. Their physiological significance is easily appreciated if one realizes that in the fasting state more than 50 per cent of the energy consumption is covered by oxidation of fatty acids [2] and their clinical importance is evident from the fact that very high FFA levels are found in the blood with several disorders, e. g. severe burns, pheochromocytoma, hyperthyroidism, and diabetes mellitus. In this latter condition the excessive fat mobilization and its consequences (fatty liver, hyperlipemia, ketonemia) are no longer considered secondary to the disturbances of carbohydrate metabolism. Fatty acids have been shown, for instance, to inhibit the action of insulin on glucose transport [16].


Adipose Tissue Epididymal Adipose Tissue Adipose Tissue Sample Lipolytic Effect Adipokinetic Hormone 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1969

Authors and Affiliations

  • Klaus Opitz
    • 1
  1. 1.Institute of PharmacologyUniversity of MunsterWest Germany

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