Stimulation of Insulin Secretion by Xylitol Administration

  • Kinori Kosaka
Conference paper


There have been increasing reports of the clinical use of xylitol solution as a parenteral infusion fluid mainly in Germany and in Japan. Particularly as an infusion fluid for diabetic patients, it is presumed to have several advantages; it does not raise the blood sugar so much [1]; it has an antiketogenic action [2, and it probably enters the cell independently of insulin action [4].


Insulin Secretion Plasma Glucose Plasma Insulin Diabetic Subject Blood Insulin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bässler, K. H., W. Prellwitz, V. Unbehaun, K. Lang: Xylitstoffwechsel beim Menschen. Klin. Wschr. 40, 791 (1962).CrossRefGoogle Scholar
  2. 2.
    Haydon, R. K.: The antiketogenic effects of polyhadric alcohols in rat-liver slices. Biochim. biophys. Acta (Amst.) 46, 598 (1961).CrossRefGoogle Scholar
  3. 3.
    Bässler, K. H., G. Dreiss: Antiketogene Wirkung von Xylit bei alloxandiabetischen Ratten. Klin. Wschr. 41, 593 (1963).PubMedCrossRefGoogle Scholar
  4. 4.Bässler, K. H., W. Prellwitz: Insulin und der Verteilungsraum von Xylit bei eviscerierten Ratten. Klin. Wschr. 42, 94 (1964).CrossRefGoogle Scholar
  5. 5.
    Kanazawa, Y., T. Kuzuya, T. Ide, K. Kosaka: Plasma insulin responses to glucose in the femoral, hepatic and pancreatic veins in dogs. Amer. J. Physiol. 211, 442 (1966).PubMedGoogle Scholar
  6. 6.
    Kuzuya, T., Y. Kanazawa, K. Kosaka: Plasma insulin response to intravenously administered xylitol in dogs. Metabolism 15, 1149 (1966).PubMedCrossRefGoogle Scholar
  7. 7.
    Hirata, Y., M. Fujisawa, H. Sato, T. Asano, S. Katsuki: Blood glucose and plasma insulin responses to xylitol administrated intravenously in dogs. Biochem. biophys. Res. Commun. 24, 471 (1966).Google Scholar
  8. 8.
    Kuzuya, T., Y. Kanazawa, H. Sando: Effect of xylitol upon insulin secretion in dogs (Abstract in Japanese). Folia endocr. Jap. 43, 281 (1967).Google Scholar
  9. 9.
    Kosaka, K., Y. Kanazawa, T. Kuzuya, M. Shimoshige, Y. Mizuno: Plasma insulin responses to xylitol in man (Abstract in Japanese). J. Jap. Diabetic Soc. 10, 142 (1967).Google Scholar
  10. 10.
    Ogawa, Y., K. Ino, T. Miyamura, T. Mizoguchi: Radioimmunoassay of blood insulin (Abstract in Japanese). Folia endocr. Jap. 42, 1373 (1967).Google Scholar
  11. 11.
    Ohnishi, Y., T. Kusumoto, T. Takano, T. Arimichi, A. Itani, S. Haraoka, T. Yamabuki, K. Kosaka: Blood insulin after xylitol administration (Abstract in Japanese). J. Jap. Diabetic Soc. 10, 65 (1967).Google Scholar
  12. 12.
    Bässler, K. H., G. Stein, W. Beizer: Xylitstoffwechsel und Xylitresorption. Biochem. Z. 346, 171 (1966).Google Scholar
  13. 13.
    Kuzuya, T., Y. Kanazawa, M. Shimoshige, K. Kosaka: Stimulation of insulin secretion by xylitol in dog and in man. Excerpta Medica, Internat. Congr. Series No. 140, 77 (1967).Google Scholar
  14. 14.
    Onoe, K., K. Kobashi, T. Yamamoto, S. Fujinaka, T. Aburaya: In vitro studies on secretion and release of insulin by the intact islets of Langerhans microdissected from mice pancreas (Abstract in Japanese). Folia endocr. Jap. 43, 277 (1967).Google Scholar
  15. 15.
    Fujisawa, M., H. Sato, Y. Hirata, S. Katsuki: Effects of glucose, fructose, sorbitol, xylitol and ribose on plasma insulin in dogs (Abstract in Japanese). Folia endocr. Jap. 42, 1370 (1967).Google Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1969

Authors and Affiliations

  • Kinori Kosaka
    • 1
  1. 1.Department of Internal MedicineTokyo Women’s Medical CollegeTokyoJapan

Personalised recommendations