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Current Topics in Microbiology and Immunology pp 107–137Cite as

Viruses of Amphibia

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 50))

Abstract

The first postulation of a virus infection of an amphibian was made over thirty years ago. The presence of intranuclear acidophilic inclusion bodies in renal adenocarcinoma cells of Rana pipiens and an increased incidence of tumors in frogs receiving cell-free tumor extracts led Lucké (1934, 1938) to suggest a viral etiology of the tumor that bears his name. The presence of herpes-type virus in inclusion-bearing tumor cells was demonstrated subsequently by Fawcett (1956). That these virus particles were indeed members of the herpesvirus group was established by physical separation of the virus from tumor extracts and characterization of viral ultrastructure by negative staining (Lunger, 1964).

“Be kind and tender to the Frog, And do not call him names, As ‘Slimy skin’, or ‘Polly-wog’, Or likewise ‘Ugly James’,

Or ‘Gape-agrin’, or ‘Toad-gone-wrong’, Or ‘Billy Bandy-knees’: The Frog is justly sensitive, To epithets like these.

No animal will more repay, A treatment kind and fair;, At least so lonely people say, Who keep a Frog (and, by the way, They are extremely rare).”

Hilaire Belloc

Supported by Public Health Service Research Grant 5 RO1 CA 07055 and ALSAC.

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Authors
  1. Allan Granoff
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Editor information

Editors and Affiliations

  1. Genève, Switzerland

    W. Arber

  2. New Brunswick, USA

    W. Braun

  3. Göttingen, Germany

    F. Cramer

  4. Freiburg, Germany

    R. Haas

  5. Philadelphia, USA

    W. Henle  & H. Koprowski  & 

  6. München, Germany

    P. H. Hofschneider

  7. Basel, Germany

    N. K. Jerne

  8. Prague, Czech Republic

    P. Koldovský  & L. Syruček  & 

  9. Copenhagen, Denmark

    O. Maaløe

  10. Gießen, Germany

    R. Rott

  11. Wilhelmshaven, Germany

    H. G. Schweiger

  12. Rehovoth, Israel

    M. Sela

  13. Seattle, USA

    P. K. Vogt

  14. Würzburg, Germany

    E. Wecker

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© 1969 Springer-Verlag Berlin · Heidelberg

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Granoff, A. (1969). Viruses of Amphibia. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 50. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46169-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-46169-9_4

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