Skip to main content
SpringerLink
Log in

Cation Specificity of Inhibitors

  • Conference paper
Inhibitors Tools in Cell Research

Part of the book series: Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden ((MOSBACH,volume 20))

Abstract

The discovery of Moore and Pressman in 1964 [1] showing that valinomycin has an alkali cation specificity in mitochondria started a great number of studies in the field of ion transport phenomena in the presence of antibiotics. The compounds studied so far and discussed here may be divided into two classes (see Table 1; for chemical structures, see Appendix). Since the compounds in Table 1 show ion specific carrier properties, they have been called “ionophores” [2]. In general, the effects of members of the valinomycin group in mitochondria may be summarized as follows [3–5]:

  1. 1)

    Accumulation of potassium ions within the mitochondria.

  2. 2)

    Ejection of hydrogen ions.

  3. 3)

    Swelling of mitochondria.

  4. 4)

    Stimulation of respiration.

  5. 5)

    Induction of ATPase activity.

  6. 6)

    Uncoupling of oxidative phosphorylation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Moore, C., and B. C. Pressman: Biochem. biophys. Res. Commun. 15, 562 (1964).

    Article  CAS  Google Scholar 

  2. Pressman, B. C., E. J. Harris, W. S. Jagger, and J. H. Johnson: Proc. nat. Acad. Sci. (Wash.) 58, 1949 (1967).

    Article  CAS  Google Scholar 

  3. Höfer, M., and B. C. Pressman: Biochemistry 5, 3919 (1966).

    Article  Google Scholar 

  4. Graven, S. N., H. A. Lardy, D. Johnson, and A. Rutter: Biochemistry 5, 1729 (1966).

    Article  PubMed  CAS  Google Scholar 

  5. Graven, S. N., H. A. Lardy, D. Johnson, and A. Rutter: Biochemistry 5, 1735 (1966). Graven, S. N., H. A. Lardy, D. JOHNSON,, and S. ESTRADA-O.: Biochemistry 6, 365 (1967).

    Article  CAS  Google Scholar 

  6. Estradao, S., S. N. Graven, and H. A. Lardy: J. biol. Chem. 242, 2925 (1967). Graven, S. N., S. ESTRADA-O., and H. A. Lardy: Proc. nat. Acad. Sci. (Wash.) 56, 654 (1966).

    CAS  Google Scholar 

  7. Corbaz, R., L. Ettlinger, E. Gäumann, W. Keller-Schierlein, F. Kradoleer, L. Neipp, V. Prelog, and H. Zähner: Helv. chim. Acta 38, 1445 (1955). Beck, J., H. Gerlach, V. Prelog, and W. Voser: Helv. chim. Acta 45, 620 (1962). Dominguez, J., J. D. Dunitz, H. Gerlach, and V. Prelog: Helv. chim. Acta 45, 129 (1962). Gerlach, H., u. V. Prelog: Liebigs Ann. Chem. 669, 121 (1963). Keller-Schierlein, W., U. H. Gerlach: Fortschr. Chem. org. Naturstoffe 26, 161 (1968).

    Article  CAS  Google Scholar 

  8. Meyers, E., F. E. Pansy, D. Perlman, D. A. Smith, and F. L. Weisenborn: J. Antibiot. (Tokyo), Ser. A 18, 128 (1965).

    CAS  Google Scholar 

  9. Pressman, B. C., and E. J. Harris: Abstracts Volume, Seventh International Congress of Biochemistry, Tokyo, August 19–25, 1967.

    Google Scholar 

  10. Štefanac, Z., U. W. Simon: Chimia (Switz.) 20, 436 (1966).

    Google Scholar 

  11. Štefanac, Z., U. W. Simon: Microchem. J. 12, 125 (1967).

    Article  Google Scholar 

  12. Mueller, P., and D. O. Rudin: Biochem. biophys. Res. Commun. 26, 398 (1967).

    Article  PubMed  CAS  Google Scholar 

  13. Pioda, L. A. R., H. A. Wächter, R. E. Dohner, and W. Simon: Helv. chim. Acta 50, 1373 (1967).

    Article  CAS  Google Scholar 

  14. Kilbourn, B. T., J. D. Dunitz, L. A. R. Pioda, and W. Simon: J. molec. Biol. 30, 559 (1967).

    PubMed  CAS  Google Scholar 

  15. Wipf, H.-K., L. A. R. Pioda, Z. Stefanac, and W. Simon: Helv. chim. Acta 51, 377 (1968).

    Article  PubMed  CAS  Google Scholar 

  16. Dobler, M., J. D. Dunitz, and J. Krajewski: J. molec. Biol. (in press).

    Google Scholar 

  17. Lardy, H. A., S. N. Graven, and S. Estrada: Fed. Proc. 26, 1355 (1967).

    PubMed  CAS  Google Scholar 

  18. Pioda, L. A. R., H.-K. Wipf and W. Simon: Chimia (Switz.) 22, 189 (1968).

    CAS  Google Scholar 

  19. Pinkerton, M., L. K. Steinrauf, and P. Dawkins: Biochem. biophys. Res. Commun. 35, 512 (1969).

    Article  PubMed  CAS  Google Scholar 

  20. L. K. Steinrauf, M. Pinkerton, and J. W. Chamberlin: Biochem. biophys. Res. Commun. 33, 29 (1968).

    Article  PubMed  CAS  Google Scholar 

  21. Agtarap, A., J. W. Chamberlin, M. Pinkerton, and L. K. Steinrauf: J. Amer. chem. Soc. 89, 5737 (1967).

    Article  CAS  Google Scholar 

  22. Simon, W.: NRP Work Session on “Carriers and Specificity in Membranes”, Mit, Brookline, Mass., February 9–11, 1969.

    Google Scholar 

  23. Shemyakin, M. M., YU. A. Ovchinnikov, V. T. Ivanov, V. K. Antonov, A. M. Shkrob, I. I. Mikhaleva, A. V. Evstratov, and G. G. Malen-Kov: Biochem. biophys. Res. Commun. 29, 834 (1967).

    Article  PubMed  CAS  Google Scholar 

  24. Eisenman, G.: Symposium on membrane transport and metabolism, special copy of communication. Prague: Publishing House of the Czechoslovak Academy of Sciences 1961.

    Google Scholar 

  25. Diebler, H., M. Eigen, G. Ilgenfritz, G. Maass, and R. Winkler: Private communication.

    Google Scholar 

  26. Pauling, L.: The nature of the chemical bond. New York: Cornell University Press 1952.

    Google Scholar 

  27. Eisenman, G., J. P. Sandblom, and J. L. Walker Jr.: Science 155, 965 (1967). Bloch, R., A. Katchalsky, O. Kedem, and D. Vofsi: Brit. Pat., Nr. 1,049,041 (1966).

    Article  PubMed  CAS  Google Scholar 

  28. Wipf, H.-K., and W. Simon: Biochem. biophys. Res. Commun. 34, 707 (1969).

    Article  PubMed  CAS  Google Scholar 

  29. Pioda, L. A. R., u. W. Simon: Chimia (Switz.) 23, 72 (1969).

    CAS  Google Scholar 

  30. Simon, W.: 135th National Meeting, The Electrochemical Society, New York City, N.Y., May 4-9, 1969.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratorium für Organische Chemie, Eidgenössischen Technischen Hochschule, Zürich, Switzerland

    W. Simon, L. A. R. Pioda & H.-K. Wipf

Authors
  1. W. Simon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. A. R. Pioda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H.-K. Wipf
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Physiologische Chemie und Physikalische Chemie, Universität München, D-8000, München 15, Goethestr. 33, Germany

    Th. Bücher  & H. Sies  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Simon, W., Pioda, L.A.R., Wipf, HK. (1969). Cation Specificity of Inhibitors. In: Bücher, T., Sies, H. (eds) Inhibitors Tools in Cell Research. Colloquium der Gesellschaft für Biologische Chemie in Mosbach Baden, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46158-3_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-46158-3_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-04441-3

  • Online ISBN: 978-3-642-46158-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation