Bioassay Procedures for Neurohypophysial Hormones and Similar Polypeptides

  • E. Stürmer
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 23)


The bioassay of active substances from the posterior pituitary is just as necessary today as it was 55 years ago when Dale and Laidlaw introduced the guinea-pig uterus method. Unfortunately, what Dale and Laidlaw regretfully admitted in 1912 is also valid: “There seems no prospect at present of the control of its (the posthypophysial extract’s) efficiency by chemical methods”, even though the complex octapeptide structure of the posthypophysial hormones has since been elucidated and confirmed by synthesis.


Posterior Lobe Depressor Response Neurohypophysial Hormone Antidiuretic Activity Synthetic Oxytocin 
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