Abstract
Aleutian disease (AD) is a slowly progressive infectious disease of mink characterized by diffuse proliferation of plasma cells, hypergammaglobulinemia, and persistent viremia. Fibrinoid vascular lesions, neurologic derangements and Coombs-positive anemia are seen as manifestations of advanced disease. Prominent clinical signs are defective hemostasis, poor appetite, gradual wasting and increased thirst. The most pronounced pathological changes occur in the liver and kidneys. In the liver, these consist of interlobular proliferation of plasma cells, proliferation of bile ducts, and loss of hepatic tissue. The major kidney lesions are perivascular and intertubular infiltrations of plasma cells, degenerative changes of tubular epithelium leading to atrophy, dilatation and hyalin cast formation, and hyalin or fibrinoid glomerular lesions. There is a strong genetic predisposition: mink which are homozygous for the Aleutian gene for coat color experience the disease in a more rapidly progressive form than non-Aleutian types of mink in which the course is more protracted, lasting several months or years.
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Karstad, L. (1967). Aleutian Disease A Slowly Progressive Viral Infection of Mink. In: Brody, J.A., Henle, W., Koprowski, H. (eds) Chronic Infectious Neuropathic Agents (CHINA) and other Slow Virus Infections. Current Topics in Microbiology and Immunology, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46059-3_3
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DOI: https://doi.org/10.1007/978-3-642-46059-3_3
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