Part of the Antibiotics book series (ANTIBIOTICS, volume 1)


Protoanemonin is an antibiotic substance produced mainly by species of Ranunculaceae. Reports of its presence are in the following references: Boas (1934), Zechner and Wohlmuth (1954), Kipping (1935), Shearer (1938), Baer et al. (1946), Herz et al. (1951), Bernard and Metzger (1960) and Tashkov et al. (1961).


Pyruvic Acid Antibiotic Activity Shigella Dysenteriae Antibiotic Substance Cytopathogenic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Asahina, Y., and A. Fujita: Synthesis and constitution of anemonin. J. Pharm. Soc. Japan 455, 1 (1920). Chem. Abstr. 14, 1384 (1920).Google Scholar
  2. Baer, H., M. Holden, and B. C. Seegal: The nature of the antibacterial agent from Anemone Pulsatilla. J. Biol. Chem. 162, 65 (1946).PubMedGoogle Scholar
  3. Bernard, M., and M. J. Metzger: Antibiotic substances from Ranunculaceae. Proc. Indiana Acad. Sci. 70, 83 (1960).Google Scholar
  4. Boas, F.: Contributions to the operating physiology of native plants. I. Ber. deut. botan. Ges. 52, 126 (1934). Chem. Abstr. 28, 3443 (1934).Google Scholar
  5. Boas, F., and R. Steube: Über die Wirkung von Anemonin auf Mikroorganismen. Biochem. Z. 279, 417 (1935).Google Scholar
  6. Brodersen, R., and A. Kjaer: The antibacterial action and toxicity of some unsaturated lactones. Acta Pharmacol. Toxicol. 2, 109 (1946).CrossRefGoogle Scholar
  7. Cavallito, C. J., and J. H. Bailey: Preliminary note on the inactivation of antibiotics. Science 100, 390 (1944).PubMedCrossRefGoogle Scholar
  8. Erickson, R. O.: Protoanemonin as a mitotic inhibitor. Science 108, 533 (1948).PubMedCrossRefGoogle Scholar
  9. Erickson, R. O., and G. U. Rosen: Cytological effects of protoanemonin on the root tip of Zea mays. Ann. J. Bot. 36, 317 (1949).CrossRefGoogle Scholar
  10. Herz, W., A. L. Pates, and G. C. Madsen: The antimicrobial principle of Clematis dioscoreifolia. Science 114, 206 (1951).PubMedCrossRefGoogle Scholar
  11. Hill, R., and R. VAN HEYNINGEN: Ranunculin: The precursor of the vesicant substance of the buttercup. J. Chem. Soc. 49, 332 (1951).Google Scholar
  12. Holden, M., B. C. Seegal, and H. Baer: Range of antibiotic activity of protoanemonin. Proc. Soc. Exptl. Biol. Med. 66, 54 (1947).Google Scholar
  13. Kipping, F. B.: Lactone of γ-hydroxyvinylacrylic acid, protoanemonin. Biochem. J. 1935, 1145.Google Scholar
  14. Mccawley, E. L., B. A. Rubin, and N. J. Giacomino: A preliminary survey of certain lactone antibiotics. Federation Proc. 5, 191 (1946).Google Scholar
  15. Moriarty, R. M., C. R. Romain, I. L. Karle, and J. Karle: The structure of anemonin. J. Am. Chem. Soc. 87, 3251 (1965).CrossRefGoogle Scholar
  16. Rotter, K., and W. Gruber: Antibiotic activity and toxicity of protoanemonin. Mikrobiol. Hochschule Bodenkult. 3, 108 (1949). Chem. Abstr. 47, 7094e (1953).Google Scholar
  17. Shearer, G. D.: Some observations on the poisonous properties of buttercups. Vet. J. 94, 22 (1938).Google Scholar
  18. Thimann, K. V., and W. D. Bonner: Inhibition of plant growth by protoanemonin and coumarin and its prevention by BAL. Proc. Natl. Acad. Sci. U.S. 35, 272 (1949).CrossRefGoogle Scholar
  19. Toshkov, As., V. Ivanov, U. Sobeva, T. Gancheva, S. Pangelova, and V. Toneva: Antibacterial, antiviral, antitoxic, and cytopathogenic properties of protoanemonin and anemonin. Antibiotiki 6, 918 (1961). Chem. Abstr. 56, 15612b (1962).PubMedGoogle Scholar
  20. Zechner, L., and H. Wohlmuth: Anemonin and protoanemonin. I. New method of isolation of anemonin from Ranunculus acerL. Sci. Pharm. 22, 74 (1954a). Chem. Abstr. 48, 13169c (19Google Scholar
  21. Zechner, L., and H. Wohlmuth: Anemonin and protoanemonin. II. Vermicidal action. Sci. Pharm. 22, 90 (1954b). Chem. Abstr. 48, 13l69d (1954).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1967

Authors and Affiliations

There are no affiliations available

Personalised recommendations