Abstract
The work described in this chapter resulted largely from the pioneering efforts of LARDY and his coworkers in their search for “toxic” antibiotics which inhibit respiration. The results of such studies have proved that this type of approach could be very fruitful, and much insight has been gained into the mechanism of oxidative phosphorylation and associated phenomena such as mitochondrial swelling and ion transport across membranes. In fact, the use of certain of the antibiotics has provided information which would have been difficult or perhaps impossible to obtain by any other means.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arnaud, C. D., and H. Rasmussen: Effect of purified parathyroid hormone added in vitro on the respiration of oligomycin-inhibited rat renal tubules. Endocrinology 75, 277 (1964).
Azzone, G. F., and L. Ernster: Compartmentation of mitochondrial phosphorylations as disclosed by studies with arsenate. J. Biol. Chem. 236, 1510 (1964).
Baldwin, C. L., L. C. Weaver, R. M. Brooker, T. N. Jacobsen, C. Osborne, Jr., and H.A. Nash: Biological and chemical properties of aurovertin, a metabolic product of Calcarisporium arbuscula. Lloydia 27, 88 (1964).
Baltscheffsky, H., and M. Baltscheffsky: Inhibitor studies on light-induced phosphorylation in extracts of Rhodospirillum rubrum. Acta Chem. Scand. 14, 257 (1960).
Brierly, G. P., E. Bachmann, and D. E. Green: Active transport of inorganic phosphate and magnesium ions by beef heart mitochondria. Proc. Natl. Acad. Sci. U.S. 48, 1928 (1962).
Bruni, A., A. R. Contessa, and P. Scallela: The binding of atractyloside and oligomycin to liver mitochondria. Biochim. et biophys. Acta 100, 1 (1965).
Bruni, A., S. Luciani, A. R. Contessa, and D. F. Azzone: Effects of atractyloside and oligomycin on energy-transfer reactions. Biochim. et Biophys. Acta 82, 630 (1964).
Chance, B.: The interaction of energy and electron transfer reactions in mitochondria. V. The energy transfer pathway. J. Biol. Chem. 236, 1569 (1961b).
Chance, B.: Energy-linked cytochrome oxidation in mitochondria. Nature 189, 719 (1961a).
Chappell, J. B., and G. D. Greville: Dependence of mitochondrial swelling on oxidizable substrates. Nature 182, 813 (1958).
Chappell, J. B., and G. D. Greville: Inhibition of electron transport and the swelling of isolated mitochondria. Nature 183, 1525 (1959a).
Chappell, J. B., and G. D. Greville: Effects of 2, 4-dinitrophenol and other agents on the swelling of isolated mitochondria. Nature 183, 1737 (1959b).
Chappell, J. B., and G. D. Greville: Mitochondrial swelling and electron transport. I. Swelling supported by ferricyanide. Biochim. et Biophys. Acta 38, 483 (1960).
Chappell, J. B., and G. D. Greville: Effects of oligomycin on respiration and swelling of isolated liver mitochondria. Nature 190, 502 (1961).
Chappell, J. B., G. D. Greville, and K. C. Bicknell: Stimulation of respiration of isolated mitochondria by manganese ions. Biochem. J. 84, 61P (1962).
Connelly, J. L., and H. A. Lardy: The effect of adenosine triphosphate and substrate on orthophosphate-induced mitochondrial swelling at acid pH. J. Biol. Chem. 239, 3065 (1964a).
Connelly, J. L., and H. A. Lardy: Antibiotics as tools for metabolic studies. III. Effects of oligomycin and aurovertin on the swelling and contraction processes of mitochondria. Biochemistry 3, 1969 (1964b).
Cooper, C., and R. G. Kulka: Properties of the inorganic orthophosphate-adenosine triphosphate and adenosine diphosphate-adenosine triphosphate exchange reactions of digitonin particles. J. Biol. Chem. 236, 2351 (1961).
Currie, W. D., and C. T. Gregg: Inhibition of the respiration of cultured mammalian cells by oligomycin. Biochem. Biophys. Research Commun. 21, 9 (1965).
Dallner, G., and L. Ernster: Induction of a crabtree-like effect in Ehrlich ascites tumor cells by oligomycin. Exptl. Cell Research 27, 372 (1962).
Danielson, L., and L. Ernster: Demonstration of a mitochondrial energy-dependent pyridine nucleotide transhydrogenase reaction. Biochem. Biophys. Research Commun. 10, 91 (1963a).
Danielson, L., and L. Ernster: Energy dependence of pyridine nucleotide-linked dismutations in rat liver mitochondria. Biochem. Biophys. Research Commun. 10, 85 (1963b).
Ernster, L.: The phosphorylation occurring in the flavoprotein region of the respiratory chain. Proc. Intern. Congr. Biochem., 5th, Moscow 1961,5, 115 (1963).
Ernster, L., and C. Lee: Biological oxidoreductions. Ann. Rev. Biochem. 33, 729 (1964).
Estabrook, R. W.: Effect of oligomycin on the arsenate and 2, 4-dinitrophenol (DNP) stimulation of mitochondrial oxidations. Biochem. Biophys. Research Commun. 4, 89 (1961).
Fang, M., and H. Rasmussen: Parathyroid hormone and mitochondrial respiration. Endocrinology 75, 434 (1964).
Fang, M., H. Rasmussen, H. F. Deluca, and R. Young: The influence of parathyroid hormone upon glutamate oxidation in isolated mitochondria. Biochem. Biophys. Research Commun. 10, 260 (1963).
Glynn, I. M.: An adenosine triphosphatase from electric organ activated by sodium and potassium and inhibited by ouabain or oligomycin. Biochem. J. 84, 75 P (1962).
Harary, I., and E. C. Slater: Studies in vitro on single beating heart cells. VIII. The effect of oligomycin, dinitrophenol and ouabain on the beating rate. Biochim. et Biophys. Acta 99, 227 (1965).
Heldt, H. W., H. Jacobs, and M. Klingenberg: Evidence for the participation of endogenous guanosine triphosphate in substrate level phosphate transfer in intact mitochondria. Biochem. Biophys. Research Commun. 17, 130 (1964).
Huijing, F., and E. C. Slater: The use of oligomycin as an inhibitor of oxidative phosphorylation. J. Biochem. (Japan) 49, 493 (1961).
Järnefelt, J.: Properties and possible mechanism of the Na+ and K+-stimulated microsomal adenosinetriphosphatase. Biochim. et Biophys. Acta 59, 643 (1962).
Jöbsis, F.F., and H. Vreman: Inhibition of sodium-and potassium-stimulated adenosinetriphosphatase by oligomycin. Biochim. et Biophys. Acta 73, 346 (1963).
Kagawa, Y., and E. Racker: A factor conferring oligomycin sensitivity to mitochondrial ATPase. Federation Proc. 24, 363 (1965).
Kulka, R. G., and C. Cooper: The action of oligomycin on the inorganic orthophosphate-adenosine triphosphate and adenosine diphosphate-adenosine triphosphate exchange reactions of digitonin particles. J. Biol. Chem. 237, 936 (1962).
Lardy, H. A., J. L. Connelly, and D. Johnson: Antibiotics as tools for metabolic studies. II. Inhibition of phosphoryl transfer in mitochondria by oligomycin and aurovertin. Biochemistry 3, 1961 (1964).
Lardy, H. A., D. Johnson, and W. C. Mcmurray: Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems. Arch. Biochem. Biophys. 78, 587 (1958).
Lardy, H. A., and W. C. Mcmurray: The mode of action of oligomycin. Federation Proc. 18, 269 (1959).
Lardy, H.A., P. Witonsky, and D. Johnson: Antibiotics as tools for metabolic studies. IV. Comparative effectiveness of oligomycins A, B, C., and rutamycin as inhibitors of phosphoryl transfer reactions in mitochondria. Biochemistry 4, 552 (1965).
Larson, M. H., and W. H. Peterson: Chromatographic study of the oligomycin complex produced under various conditions of fermentation. Appl. Microbiol. 8, 182 (1960).
Lee, C. P., G. F. Azzone, and L. Ernster: Evidence for energy coupling in non-phosphorylating electron transport particles from beef-heart mitochondria. Nature 201, 152 (1964).
Lee, C., and L. Ernster: Restoration of oxidative phosphorylation in non-phosphorylating submitochondrial particles by oligomycin. Biochem. Biophys. Research Commun. 18, 523 (1965).
Lehninger, A. L.: Intermediate enzymatic reactions in the coupling of phosphorylation to electron transport. Symp. Intracellular respiration: Phosphorylating and non-phosphorylating oxidation reduction. Proc. Intern. Congr. Biochem., 5th, Moscow 1961, 5, 239 (1963).
Lenaz, G.: Effect of aurovertin on energy-linked processes related to oxidative phosphorylation. Biochem. Biophys. Research Commun. 21, 170 (1965).
Marty, E. W., Jr., and E. Mccoy: The chromatographic separation and biological properties of the oligomycins. Antibiotics & Chemotherapy 9, 286 (19
Masamune, S., J. M. Sehgal, E. E. VAN TAMELEN, F. M. Strong, and W. H. Peterson: Separation and preliminary characterization of oligomycins A, B, and C. J. Am. Chem. Soc. 80, 6092 (1958).
Michel, R., P. Huet, and M. Huet: Action of rutamycin (A 272) on rat hepatic mitochondria adenosinetriphosphatases. Compt. rend. soc. biol. 158, 994 (1964).
Minakami, S., K. Kakinuma, and H. Yoshikawa: The control of respiration in brain slices. Biochim. et Biophys. Acta 78, 808 (1963).
Minakami, S., and H. Yoshikawa: Effect of oligomycin on the phosphorylating respiration of ascites hepatoma cells. Biochim. et Biophys. Acta 74, 793 (1963).
Neubert, D., and A. L. Lehninger: Effect of oligomycin, gramicidin and other antibiotics on reversal of mitochondrial swelling by adenosine triphosphate (ATP). Biochim. et Biophys. Acta 62, 556 (1962).
Sallis, J. D., and H. F. Deluca: Parathyroid hormone interaction with the oxidative phosphorylation chain. Effect on adenosine-triphosphatase activity and the adenosine triphosphate-orthophosphate exchange reaction. J. Biol. Chem. 239, 4303 (1964).
Sallis, J. D., H. F. Deluca, and D. L. Martin: Parathyroid hormone-dependent transport of inorganic phosphate by rat liver mitochondria. Effect of phosphorylation chain inhibitors. J. Biol. Chem. 240, 2229 (1965).
Sallis, J. D., H. F. Deluca, and H. Rasmussen: Parathyroid hormone stimulation of phosphate uptake by rat liver mitochondria. Biochem. Biophys. Research Commun. 10, 266 (1963a).
Sallis, J. D., H. F. Deluca, and H. Rasmussen: Parathyroid hormone-dependent uptake of inorganic phosphate by mitochondria. J. Biol. Chem. 238, 4098 (1963b).
Slater, E. C., and J. M. Tager: Synthesis of glutamate from α-oxoglutarate and ammonia in rat-liver mitochondria. V. Energetics and mechanism. Biochim. et Biophys. Acta 77, 276 (1963).
Slater, E. C., J. M. Tager, and A. M. Snoswell: The mechanism of the reduction of mitochondrial DPN+ coupled with the oxidation of succinate. Biochim. et Biophys. Acta 56, 177 (1962).
Smith, R. M., W. H. Peterson, and E. Mccoy: Oligomycin, a new antifungal antibiotic. Antibiotics & Chemotherapy 4, 962 (1954).
Snoswell, A. M.: The mechanism of the reduction of mitochondrial diphosphopyridine nucleotide by succinate in rabbit-heart sarcosomes. Biochim. et Biophys. Acta 52, 216 (1961).
Snoswell, A. M.: The reduction of diphosphopyridine nucleotide of rabbit-heart sarcosomes by succinate. Biochim. et Biophys. Acta 60, 143 (1962).
Stoner, C., and J. Hanson: Swelling and contraction of corn mitochondria. Plant Physiol. 41, 255 (1966).
Tager, J. M.: Synthesis of glutamate from a-oxoglutarate and ammonia in rat-liver mitochondria. III. Malate as hydrogen donor. Biochim. et Biophys. Acta 77, 258 (1963).
Tager, J. M., J. L. Howland, E. C. Slater, and A. M. Snoswell: Synthesis of glutamate from a-oxoglutarate and ammonia in rat-liver mitochondria. IV. Reduction of nicotinamide nucleotide coupled with the aerobic oxidation of tetramethyl-p-phenylenediamine. Biochim. et Biophys. Acta 77, 266 (1963).
Tager, J. M., and E. C. Slater: Synthesis of glutamate from α-oxoglutarate and ammonia in rat-liver mitochondria. II. Succinate as hydrogen donor. Biochim. et Biophys. Acta 77, 246 (1963a).
Tager, J. M., and E. C. Slater: Synthesis of glutamate from a-oxoglutarate and ammonia in rat-liver mitochondria. I. Comparison of different hydrogen donors. Biochim. et Biophys. Acta 77, 227 (1963b).
Thompson, R. Q., M. M. Hoehn, and C. E. Higgins: Crystalline antifungal antibiotic isolated from a strain of Streptomyces rutgersensis. Antimicrobial Agents and Chemotherapy, p. 474 (1961).
Tobin, R. B., and E. C. Slater: The effect of oligomycin on the respiration of tissue slices. Biochim. et Biophys. Acta 105, 214 (1965).
Utsumi, K., and G. Yamamoto: Mitochondrial swelling and uncoupling of oxidative phosphorylation by arginine-rich histone extracted from calf thymus. Biochim. et Biophys. Acta 100, 606 (1965).
Van Rossum, G. D. V.: Effect of oligomycin on cation transport in slices of rat liver. Biochem. J. 84, 35 P (1962).
Van Rossum, G. D. V.: Effect of oligomycin on net movements of sodium and potassium in mammalian cells in vitro. Biochim. et Biophys. Acta 82, 556 (1964).
Van Gronigen, M. E. M., and E. C. Slater: Effect of oligomycin on the (Na+ + Reactivated Mg++ ATPase of brain microsomes and erythrocyte membranes. Biochim. et Biophys. Acta 73, 527 (1963).
Wadkins, C. L.: Inhibition of the dinitrophenol-sensitive adenosine triphosphate (ATP)-adenosine diphosphate (ADP) exchange reaction by oligomycin. Biochem. Biophys. Research Commun. 7, 70 (1962).
Wadkins, C. L., and A. L. Lehninger: Role of ATP-ADP exchange reaction in oxidative phosphorylation. Federation Proc. 22, 1092 (1963a).
Wadkins, C. L., and A. L. Lehninger: Distribution of an oligomycin-sensitive adenosine triphosphate-adenosine diphosphate exchange reaction and its relationship to the respiratory chain. J. Biol. Chem. 238, 2555 (1963b).
Whittam, R., K. P. Wheeler, and A. Blake: Oligomycin and active transport reactions in cell membranes. Nature 203, 720 (1964).
Wu, R.: Effect of azide and oligomycin on inorganic phosphate transport in slices of rat kidney. Biochim. et Biophys. Acta 82, 212 (1964).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1967 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Shaw, P.D. (1967). Oligomycin Complex, Rutamycin and Aurovertin. In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_43
Download citation
DOI: https://doi.org/10.1007/978-3-642-46051-7_43
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-46053-1
Online ISBN: 978-3-642-46051-7
eBook Packages: Springer Book Archive