Abstract
The growing interest in the application of NMR spectroscopy to intact biological systems has placed unique demands on instrumentation. Perhaps the most critical piece of instrumentation for the in-vivo spectroscopist is the NMR probe. The need to perform quick and reliable experiments, particularly in the clinical setting, makes probe sensitivity critical. Many studies involve the use of more than one nucleus. Typically, proton NMR is used to shim, obtain localizing images and/or spectra. Additional spectra may be acquired from 31P, 23Na, 13C or other nuclei. This multinuclear approach to in-vivo NMR spectroscopy has placed a premium on multiple tuned NMR probes that perform with high sensitivity. There are many designs for double tuned probes in the NMR literature. Some designs for probes tuned to three and four nuclei have also been presented. All of these designs must sacrifice some sensitivity at one or more of the resonant frequencies at which they operate when compared to a similar single tuned coil. One common strategy of all of the multiple tuned probe designs is to minimize the loss in sensitivity. In most designs it is possible to arbitrarily distribute the loss in sensitivity between the different operating frequencies of the probe by proper choice of component values. Thus the evaluation of any multiple tuned probe can only be performed if the probe is optimized for a particular application. A second, less frequently discussed aspect of multiple tuned NMR probes is orthogonal tuning adjustment. In the in vivo setting it is very difficult to control loading of the probe. Therefore, the tuning must be adjusted with each application. Independent tuning of the individual resonances is important to ensure reliable performance by the probe. In this paper, I will discuss in detail many of the multiple tuned designs that have appeared in the NMR literature, paying particular attention to the advantages and disadvantages of each. I will focus on multiple tuned surface coils, but will also treat double tuned volume coils, which are of importance in the context of volume selective MRS techniques.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Abbreviations
- A:
-
magnetic vector potential
- B:
-
magnetic field intensity (scalor)
- B:
-
magnetic field vector
- C:
-
capacitance
- E:
-
Efficiency emf electramotive force
- F:
-
effective filling factor
- 1:
-
current
- i:
-
(− 1)½
- K:
-
coupling constant
- k:
-
Boltzman constant
- L:
-
inductance
- M:
-
magnetization vector
- M:
-
magnitude of magnetization vector
- M :
-
mutual inductance
- Q:
-
quality factor (Lω/r)
- r:
-
resistance (ohms)
- T:
-
temperature (kelvin)
- X:
-
reactance (ohms)
- Z:
-
impedance (ohms)
- β:
-
B/I
- Δ∫:
-
frequency range
- ω:
-
frequency
References
Hoult D, Richards RE (1976) J Magn Reson 24: 71.
Hoult DI (1976) Progress in NMR Spectroscopy 12: 41.
Bottomly PA, Andrew RA (1976) Phys Med Biol 23: 630.
Murphy-Boesch J, Koretzky AP (1983) J Magn Reson 54: 26.
Decorps M (1985) J Magn Reson 65: 100.
Misc G (1987) Radiology 165: 344.
Hoult DI, Chen CN (1988) In: Proc. seventh annual meeting Soc Magn Reson Med, 20–26 Aug. San Fransico.
Froncisz W, Jesmanowicz A, Hyde JS (1956) J Magn Reson 66: 135.
Kuhns PL, Lizak MJ, Lee S, Conradi MS (1988) J Magn Reson 78: 69.
Schnall MD, Barlow C, Subramanian VH, Leigh JS (1986) J Magn Reson 68: 161.
Schnall MD, Subramanian VH, Leigh JS, Chance B (1985) J Magn Reson 65: 122.
Chew WM, Taveres N, Auffermann W, Higgans CB (1988) Mag Res Med 7: 321.
Rajan SS, Wehrle JP, Glickson JD (1987) J Magn Reson 74: 147.
Edelstein WA, Hardy CJ, Meuller OM (1986) J Magn Reson 67: 156.
Bendall MR (1988) J Magn Reson 8: 380.
Prammer MG, Vogele KE, Leigh JS (1989) In: Proc. eighth annual meeting Soc Magn Reson Med, 12–18 Aug. Amsterdam, The Netherlands.
Purington ES (1930) Proc I.R.E. 18: 983.
Aiken CB (1937) Proc I.R.E. 25: 230.
Schnall MD, Subramanian VH, Leigh JS (1986) J Magn Reson 67: 129.
Terman FE (1943) Radio Engineer’s Handbook, 1st edn, McGraw Hill, New York p 151.
Fitzimmons JR, Brooker HR, Beck B (1987) Magn Reson Med 5: 471.
Grist TM, Kneeland JB, Jesmanowicz A, Francisz W, Hyde JS (1988) Mag Res Med 6: 253.
Eleff SE, Schnall MD, Ligetti L, Osbakken M, Subramanian VH, Chance B, Leigh JS (1988) Mag Res Med 7: 412.
Styles P, Soffe NF, Scott CA, Cragg DA, Row F, White DJ, White PCJ (1984) J Magn Reson 60: 397.
Damico LA, Summers JJ, Schnall MD (1987) In: Proc. sixth annual meeting Soc Magn Reson Med, 17–21 Aug. New York.
Boesch C, Martin E (1988) Radiology 168: 481.
Cross TA, Mueller S, Aue WP (1985) J Magn Reson 62: 87.
Bolinger L, Prammer M, Leigh JS (1989) J Magn Reson 81: 162.
Hayes CE, Edelstein WA, Schenk JF, Mueller OM, Eash M (1985) J Magn Reson 63: 662.
Mascart E, Joubert J (1886) Lecons sur l’electricite et le magnetisme 1: 357.
Rath A (1989) In: Proc. eigths annual meeting Soc Magn Reson Med, 12–18 Aug. Amsterdam, The Netherlands.
Isac G, Schnall MD, Lenkinski RL, Vogele K (1990) J Magn Reson 89: 41.
Fitzimmons JR, Beck B (1990) In: Proc. ninth annual meeting Soc Magn Reson Med, 18–24 Aug. New York.
Joseph PM, Lu D (1989) IEEE Trans Med Imaging 8: 286.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag, Berlin Heidelberg
About this chapter
Cite this chapter
Schnall, M. (1992). Probes Tuned to Multiple Frequencies for In-Vivo NMR. In: Rudin, M. (eds) In-Vivo Magnetic Resonance Spectroscopy I: Probeheads and Radiofrequency Pulses Spectrum Analysis. NMR, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45697-8_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-45697-8_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-45699-2
Online ISBN: 978-3-642-45697-8
eBook Packages: Springer Book Archive