Summary
Adenosine acts to modulate a complex array of physiologic processes in a wide variety of cell types. Perhaps no other organ demonstrates the diverse cellular action of adenosine better than the kidney. With its numerous types of tubular epithelia, endothelium, vascular smooth muscle, nerves, and hormonal secretory cells, the kidney has become an interesting model in which to develop a unified hypothesis to explain the diverse actions of adenosine as a cellular regulator. Recent technical advances allowing the isolation of large numbers of specific renal cell types have provided a means of identifying which renal cell types have adenosine receptors and what postreceptor mechanisms are involved in mediating the actions of adenosine.
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References
Abboud HE, Dousa TP (1983) Action of adenosine on cyclic 3’5’-nucleotides in glomeruli. Am J Physiol 244:F633–F638
Arend LJ, Haramati A, Thompson CI, Spielman WS (1984) Adenosine-induced decrease in renin release: dissociation from hemodynamic effects. Am J Physiol 247:F447–F452
Arend LJ, Sonnenburg WK, Smith WL, Spielman WS (1986) Evidence for A1 and A2 adeno-sine receptors in rabbit cortical collecting tubule cells: modulation of hormone-stimulated cAMP (to be published)
Arend LJ, Thompson CI, Spielman WS (1985) Dipyridamole decreases glomerular filtration in the sodium-depleted dog. Evidence for mediation by intrarenal adenosine. Circ Res 56:242–251
Arend LJ, Thompson CI, Brandt MA, Spielman WS (1986) Elevation of intrarenal adenosine by maleic acid decreases GFR and renin release. Kidney Int
Brezis M, Rosen S, Silva P, Epstein FH (1984) Renal ischemia: a new perspective. Kidney Int 26:375–383
Churchill PC, Bidani AK (1982) Hypothesis: adenosine mediates hemodynamic changes in renal failure. Med Hypotheses 8:275–285
Dillingham MA, Anderson RJ (1985) Purinergic regulation of basal and arginine vasopres-sin-stimulated hydraulic conductivity in rabbit cortical collecting tubule. J Membr Biol 88:277–281
Dobbins JW, Laurenson JP, Forrest JN Jr (1984) Adenosine and adenosine analogs stimulate adenosine cyclic 3′,5′-monophosphate-dependent chloride secretion in the mammalian ileum. J Clin Invest 74:929–935
Eveloff J, Kinne R, Kinne-Saffran E, Murer H, Silva P, Epstein FH, Stoff J, Kinter WB (1978) Coupled sodium and chloride transport into plasma membrane vesicles. Pflügers Arch 378:87–92
Forrest JN Jr, Rieck D, Murdaugh A (1980) Evidence for a ribose-specific adenosine receptor (Ra) mediating stimulation of chloride secretion in the rectal gland of Squalus acanthias. Bull Mt Desert Isl Biol Lab 20:152–155
Forrest JN Jr, Poeschla E, Rieck D (1982) Ribose-specific adenosine receptors mediate cyclic AMP accumulation and chloride transport in the shark rectal gland. Kidney Int 21:253 (Abstract)
Forrest JN Jr, Wang F, Beyenbach KW (1983) Perfusion of isolated tubules of the shark rectal gland: electrical characteristics and responses to hormones. J Clin Invest 72:1163–1167
Forrest JN Jr, Kelly G, Gifford D, Poeschla E, Sander S, Osswald H (1984) Characteristics of adenosine receptors mediating chloride transport. Clin Res 32:532A (Abstract)
Fredholm BB, Hedqvist P (1978) Release of [3H]purines from [3H]adenine-labelled rabbit kidney following sympathetic nerve stimulation, and its inhibition by alpha-adrenoreceptor blockade. Br J Pharmacol 64:239–245
Garcia-Perez A, Smith WL (1983) Use of monoclonal antibodies to isolate cortical collecting tubule cells: AVP induces PGE release. Am J Physiol 244:C211–C220
Grasl M, Turnheim K (1984) Stimulation of electrolyte secretion in rabbit colon by adenosine. J Physiol 346:93–110
Hall JE, Granger JP (1986) Adenosine alters glomerular filtration control by angiotensin II. Am J Physiol 250:F917–F923
Hall JE, Granger JP, Hester RL (1985) Interactions between adenosine and angiotensin II in controlling glomerular filtration. Am J Physiol 248:F340–F346
Hedqvist P, Fredholm BB, Olundh S (1978) Antagonistic effects of theophylline and adenosine on adrenergic neuroeffector transmission in the rabbit kidney. Circ Res 43:592–598
Kelley GG, Gifford DR, Wang F, Forrest JN Jr (1984) Stimulation and inhibition of adeny-late cyclase in the rectal gland. Bull Mt Desert Isl Biol Lab 24:102–104
Kelley GG, Curtis WS, Nuland AM, Forrest JN Jr (1985) Endogenous adenosine inhibits chloride secretion in the shark rectal gland via an A1 adenosine receptor coupled to the inhibitory nucleotide regulatory protein. Bull Mt Desert Isl Biol Lab 25:108–110
Lang MA, Preston AS, Handler JS, Forrest JN Jr (1985) Adenosine stimulated sodium transport in kidney A6 epithelia in culture. Am J Physiol 249:C330–C336
Murray RD, Churchill PC (1984) The effects of adenosine receptor agonists in the isolated perfused rat kidney. Am J Physiol 247:H343–H348
Osswald H (1975) Renal effects of adenosine and their inhibition by theophylline. Naunyn Schmeidebergs Arch Pharmacol 288:79–86
Osswald H, Hermes HH, Nabakowski G (1982) Role of adenosine in signal transmission of tubuloglomerular feedback. Kidney Int 22:S136–S142
Osswald H, Nabakowski G, Hermes H (1980) Adenosine as a possible mediator of metabolic control of glomerular filtration rate. Int J Biochem 12:263–267
Osswald H, Spielman WS, Knox FG (1978) Mechanisms of adenosine-mediated decreases in glomerular filtration rate in dogs. Circ Res 43:465–469
Osswald H, Sander S, Forrest JN (1983) Binding of ligands to adenosine receptors in the rectal gland of Squalus acanthias. Bull. Mt. Desert Isl. Biol Lab 23:90–96
Poeschla E, Kelly G, Forrest JN Jr (1982) Evidence for an inhibitory adenosine receptor in the rectal gland of Squalus acanthias. Bull Mt Desert Isl Biol Lab 22:S19–S23
Poeschla E, Kelly GG, Gifford D, Forrest JN Jr (1985) Identification of adenosine receptor subtypes in the shark rectal gland. Clin Res 33:587A (Abstract)
Rossi N, Churchill P, Churchill M (1986) N6-Cyclohexyladenosine inhibits in vitro renin secretion by a cyclic AMP dependent process. Fed Proc 45:868 (Abstract)
Silva PJ, Stoff J, Field M, Fine L, Forrest JN, Epstein FH (1977) Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport. Am J Physiol 233:F298–F306
Smith WL, Garcia-Perez A (1985) Immunodissection: use of monoclonal antibodies to isolate specific types of renal cells. Am J Physiol 248:F1–F7
Spielman WS (1984) Antagonistic effect of theophylline on the adenosine-induced decrease in renin release. Am J Physiol 247:F246–F251
Spielman WS, Osswald H (1978) Characterization of the postocclusive response of renal blood flow in the cat. Am J Physiol 235:F286–F290
Spielman WS, Osswald H (1979) Blockade of postocclusive renal vasoconstriction by an angiotensin II antagonist: evidence for an angiotensin-adenosine interaction. Am J Physiol 237:F463–F467
Spielman WS, Thompson CI (1982) A proposed role for adenosine in the regulation of renal hemodynamics and renin release. Am J Physiol 242:F423–F435
Spielman WS, Britton SL, Fiksen-Olsen MJ (1980) Effect of adenosine on the distribution of renal blood flow in dogs. Circ Res 46:449–456
Spielman WS, Sonnenberg WK, Allen ML, Arend LJ, Gerozissis K, Smith WL (1986) Immunodissection and culture of rabbit cortical collecting tubule cells. Am J Physiol 251:F348–F357
Spinowitz BS, Zadunaisky JA (1979) Action of adenosine on chloride active transport of isolated frog cornea. Am J Physiol 237:F121–F127
Stoff JS, Rosa R, Hallac R, Silva P, Epstein FH (1979) Hormonal regulation of active chloride transport in the dogfish rectal gland. Am J Physiol 237:F138–F144
Tagawa H, Vander AJ (1970) Effects of adenosine compounds on renal function and renin secretion in dogs. Circ Res 26:327–338
Thurau L (1964) Renal hemodynamics. Am J Med 36:698–719
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© 1987 Springer-Verlag Berlin Heidelberg
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Spielman, W.S., Arend, L.J., Forrest, J.N. (1987). The Renal and Epithelial Actions of Adenosine. In: Gerlach, E., Becker, B.F. (eds) Topics and Perspectives in Adenosine Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45619-0_20
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DOI: https://doi.org/10.1007/978-3-642-45619-0_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-45621-3
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