Polyketide Pathway. Biosynthesis of Diverse Classes of Aromatic Compounds

  • Sunil Kumar Talapatra
  • Bani Talapatra


In 1893, a young chemist, John Norman Collie at London University serendipitously discovered a set of reactions while establishing the structure of dehydroacetic acid [1]. On boiling dehydroacetic acid with Ba(OH)2 and its subsequent work up with acid, Collie obtained a phenol, orcinol, whose structure he could correctly assign [1, 2]. He even offered an explanation on the formation of orcinol from dehydroacetic acid (Fig. 14.1). This concept of a triketone formation as the intermediate has been the cornerstone of the polyketide pathway [3].


Acetyl Coenzyme Shikimic Acid Pathway Cross Metathesis Polyketide Chain Catechin Gallate 
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Further Reading

  1. T. J. Mabry, K. R. Markham, and M. B. Thomas, The Systematic Identification of Flavonoids, Springer-Verlag, New York, Heidelberg, Berlin, 1970.CrossRefGoogle Scholar
  2. The Flavonoids, edited by J. B. Harborne, T. J. Mabry, and Helga Mabry, Parts I and II, Academic Press, New York, 1975. Google Scholar
  3. The Flavonoids, edited by J. B. Harborne and H. Mabry, Chapman and Hall, New York, London, 1988. Google Scholar
  4. B. A. Bohn, Introduction to Flavonoids, Harwood Academic Publishers, Amsterdam, 1999.Google Scholar
  5. Gerard M. Boland and Dervilla M. X. Donnelly, Flavonoids and Related Compounds, Nat. Prod. Rep., 1998, 241-260Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Sunil Kumar Talapatra
    • 1
  • Bani Talapatra
    • 1
  1. 1.Dept. ChemistryUniversity of CalcuttaKolkataIndia

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