The Use of Ultrasonic Bath Extracts in the Diagnostics of Contact Allergy and Allergic Contact Dermatitis
Investigation of patients with suspected allergic contact dermatitis always requires patch testing with a baseline series but frequently also with additional series and patient-supplied products/materials. Many products/materials can be tested as they are, but sometimes this testing can be false negative. The undiagnosed contact allergy can still be clinically relevant, particularly when the undiagnosed contact allergy to the product/material is weak and the exposure to the product/material is extensive. The idea behind patch testing with ultrasonic bath extracts is to test a possible but unknown contact sensitizer at a higher concentration than what is present in the product, which will yield/has yielded a negative reaction when tested as is. The extraction procedure using an ultrasonic bath means an improved device to get standardized extracts from the same kind of products in a short time with regard to extraction area and time, volume of extracting solvent, use of ultrasonic bath, and evaporation, which enables the patient to be tested with extracts of patient-supplied products at the first visit to the patch test clinic.
KeywordsContact Dermatitis Patch Testing Allergic Contact Dermatitis Contact Allergy Contact Sensitizer
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