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Aging and Cell Aging: An Introduction

  • Christian Behl
  • Christine Ziegler
Chapter
Part of the SpringerBriefs in Molecular Medicine book series (BRIEFSMOME)

Abstract

Since more than 100 years people are constantly growing older and a further significant increase in life time is expected in the decades to come. A person born today has a high statistical chance to reach the age of 100, to become a centenarian. Since aging is the primary risk factor for many human disorders it is mandatory to understand the aging process and how it affects onset and course of disorders of the elderly. Scientifically the medium life span is discriminated from the maximum life span. While the latter is rather constant at approximately 120 years the medium life span is increasing. But not only the whole organism, also each single cell out of the billions making up our body has an individual life span ranging from days to months and years until it is eventually dying or exchanged. The majority of our nerve cells is never replaced. Understanding cellular aging and its influence on human disease is a key challenge of molecular medicine research.

Keywords

Medium life span Maximum life span Life expectancy Aging process Age-associated disorders Predisposition 

References

  1. Behl C (2002) Oestrogen as a neuroprotective hormone. Nat Rev Neurosci 3(6):433–442PubMedGoogle Scholar
  2. Bettens K, Sleegers K, Van Broeckhoven C (2013) Genetic insights in Alzheimer’s disease. Lancet Neurol 12(1):92–104PubMedCrossRefGoogle Scholar
  3. Brindle N, George-Hyslop PS (2000) The genetics of Alzheimer’s disease. Methods Mol Med 32:23–43PubMedGoogle Scholar
  4. Christenson ES, Jiang X, Kagan R, Schnatz P (2012) Osteoporosis management in post-menopausal women. Minerva Ginecol 64(3):181–194PubMedGoogle Scholar
  5. Faulds MH, Zhao C, Dahlman-Wright K, Gustafsson JÅ (2012) The diversity of sex steroid action: regulation of metabolism by estrogen signaling. J Endocrinol 212(1):3–12PubMedCrossRefGoogle Scholar
  6. Finch CE (2007) The biology of human longevity: inflammation, nutrition, and aging in the evolution of lifespans, 1st edn. Academic Press, BurlingtonGoogle Scholar
  7. Gambrell RD Jr (1982) The menopause: benefits and risks of estrogen-progestogen replacement therapy. Fertil Steril 37(4):457–474PubMedGoogle Scholar
  8. Grandel H, Brand M (2013) Comparative aspects of adult neural stem cell activity in vertebrates. Dev Genes Evol 223(1–2):131–147PubMedCrossRefGoogle Scholar
  9. Hunter S, Arendt T, Brayne C (2013) The senescence hypothesis of disease progression in alzheimer disease: an integrated matrix of disease pathways for FAD and SAD. Mol Neurobiol. 3 Apr 2013Google Scholar
  10. Kirkwood TB (1999) Time of our lives: the science of human aging, 1st edn. Oxford University Press, New YorkGoogle Scholar
  11. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6):1194–1217PubMedCrossRefGoogle Scholar
  12. Montesanto A, Dato S, Bellizzi D, Rose G, Passarino G (2012) Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. Immun Ageing 9(1):6PubMedCentralPubMedCrossRefGoogle Scholar
  13. Scully T (2012) To the limit. Nature 492:S2Google Scholar

Copyright information

© The Author(s) 2014

Authors and Affiliations

  1. 1.Institute for PathobiochemistryUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany

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