Zusammenfassung
Das Risiko der Bagatellisierung eines akuten Nierenfunktionsverlusts ist insgesamt hoch. Im klinischen Alltag erfolgt die Erkennung und Behandlung einer akuten Nierenschädigung zumeist zeitverzögert und nur in 10–40% der Fälle durch eine spezialisierte Disziplin. Die Frühdiagnose und individualisierte Ursachensuche sowie Behandlung der akuten Nierenschädigung stehen im Vordergrund. Klinische Akutmaßnahmen umfassen das Vermeiden von Nephronoxen bzw. den Ausschluss oder die Behandlung eines Harnstaus, einer Sepsis und der Komplikationen einer akuten Nierenschädigung. In der Literatur liegen ausreichende Hinweise für den klinischen Nutzen einer frühzeitigen und multimodalen Behandlung der akuten Nierenschädigung vor. Eine Verbesserung der Prognose betroffener Patienten wird durch optimierte Behandlungspfade wie einer verbesserten Nutzung etablierter Marker mittels EDV-gestützter Frühwarnsysteme (“AKI-Alarm”) und der Ausgabe eines Patientenausweises (“Nieren-Pass”) angestrebt.
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Literatur
Ali T, Tachibana A, Khan I, Townend J, Prescott GJ, Smith WC, Simpson W, Macleod A. The changing pattern of referral in acute kidney injury. QJM. 2011;104:497–503
ANZICS-CORE MET dose investigators Mortality of rapid response team patients in Australia: a multicentre study. Crit Care Resusc. 2013;15:273–8
Balasubramanian G, Al-Aly Z, Moiz A, Rauchman M, Zhang Z, Gopalakrishnan R, Balasubramanian S, El-Achkar TM. Early nephrologist involvement in hospital-acquired acute kidney injury: a pilot study. Am J Kidney Dis. 2011;57:228–34
Bray B, Matthews B, O‘Donoghue D. The Capacity of Nephrology and Critical Care Services in England and Wales to Manage Acute Kidney Injury. ASN Kidney Week 2011, THPO097
Colpaert K, Hoste EA, Steurbaut K, Benoit D, Van Hoecke S, De Turck F, Decruyenaere J. Impact of real-time electronic alerting of acute kidney injury on therapeutic intervention and progression of RIFLE class. Crit Care Med. 2012;40:1164–70
Costa e Silva VT, Liaño F, Muriel A, Díez R, de Castro I, Yu L. Nephrology referral and outcomes in critically ill acute kidney injury patients. PLoS One. 2013;8:e70482
Cruz DN, Bagshaw SM, Maisel A, Lewington A, Thadhani R, Chakravarthi R, Murray PT, Mehta RL, Chawla LS. Use of biomarkers to assess prognosis and guide management of patients with acute kidney injury. Contrib Nephrol. 2013;182:45–64
Flynn N, Dawnay A. A simple electronic alert for acute kidney injury. Ann Clin Biochem. 2014 Apr 24. pii: 0004563214534832. [Epub ahead of print]
Haase M, Robra BP, Hoffmann J, Isermann B, Henkel W, Bellomo R, Ronco C, Haase-Fielitz A. Management of Acute Kidney Injury – Is there an unmet medical need? [MP090] Poster ERA-EDTA Amsterdam 2014
Harel Z, Wald R, Bargman JM, Mamdani M, Etchells E, Garg AX, Ray JG, Luo J, Li P, Quinn RR, Forster A, Perl J, Bell CM. Nephrologist follow-up improves all-cause mortality of severe acute kidney injury survivors. Kidney Int. 2013;83:901–8
KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl. 2012 doi:10.1038/kisup.2012
Kerr M, Bedford M, Matthews B, O'Donoghue D. The economic impact of acute kidney injury in England. Nephrol Dial Transplant. 2014;29:1362–8
McCullough PA, Shaw AD, Haase M, Bouchard J, Waikar SS, Siew ED, Murray PT, Mehta RL, Ronco C. Diagnosis of acute kidney injury using functional and injury biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference. Contrib Nephrol. 2013;182:13–29
Mehta RL, McDonald B, Gabbai F, Pahl M, Farkas A, Pascual MT, Zhuang S, Kaplan RM, Chertow GM. Nephrology consultation in acute renal failure: does timing matter? Am J Med. 2002;113:456–461
Menachem I, Ami M, Barlavie Y. Electronic urine output monitoring – a novel approach for patient care improvement. Connect: The World of Critical Care Nursing 2008, connectpublishing.org/assets/journals/6_4_4.pdf
Mishra J, Mori K, Ma Q, Kelly C, Yang J, Mitsnefes M, Barasch J, Devarajan P. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol. 2004;15:3073–82
Ponce D, Zorzenon Cde P, dos Santos NY, Balbi AL. Early nephrology consultation can have an impact on outcome of acute kidney injury patients. Nephrol Dial Transplant. 2011;26:3202–6
Porter CJ, Juurlink I, Bisset LH, Bavakunji R, Mehta RL, Devonald MA. A real-time electronic alert to improve detection of acute kidney injury in a large teaching hospital. Nephrol Dial Transplant. 2014;29:1888–93
Selby NM, Crowley L, Fluck RJ, McIntyre CW, Monaghan J, Lawson N, Kolhe NV. Use of electronic results reporting to diagnose and monitor AKI in hospitalized patients. Clin J Am Soc Nephrol. 2012;7:533–40
Siew ED, Peterson JF, Eden SK, Hung AM, Speroff T, Ikizler TA, Matheny ME. Outpatient nephrology referral rates after acute kidney injury. J Am Soc Nephrol. 2012;23:305–312
Stewart J, National Confidential Enquiry into Patient Outcome and Death. Adding insult to injury: a review of the care of patients who died in hospital with a primary diagnosis of acute kidney injury (acute renal failure): a report of the National Confidential Enquiry into Patient Outcome and Death (2009). London: National Confidential Enquiry into Patient Outcome and Death; 2009, available from: ▶ http://www.ncepod.org.uk/2009report1/Downloads/AKI_report.pdf
Wallace K, Mallard AS, Stratton JD, Johnston PA, Dickinson S, Parry RG. Use of an electronic alert to identify patients with acute kidney injury. Clin Med. 2014;14:22–6
Wang Z, Liu Y, Han Y, Guan W, Kou X, Fu J, Yang D, Ren H, He D, Zhou L, Zeng C. Protective effects of aliskiren on ischemia-reperfusion-induced renal injury in rats. Eur J Pharmacol. 2013;718:160–6
Winters BD, Weaver SJ, Pfoh ER, Yang T, Pham JC, Dy SM. Rapid-response systems as a patient safety strategy: a systematic review. Ann Intern Med. 2013;158:417–25
Xie M, Iqbal S. Predictors for nephrology outpatient care and recurrence of acute kidney injury (AKI) after an in-hospital AKI episode. Hemodial Int. 2014;Suppl 1:1S7–S12
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Haase, M., Haase-Fielitz, A. (2015). Akute Nierenschädigung – Frühwarnsystem und neue Behandlungspfade. In: Haase, M., Haase-Fielitz, A. (eds) Akute Nierenschädigung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45080-8_2
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