Zusammenfassung
Die Infektpseudarthrose ist eine mögliche Ursache für das Ausbleiben der knöchernen Konsolidierung nach Frakturbehandlung oder chirurgischen Knocheneingriffen. Sie ist eine schwerwiegende Komplikation und erfordert eine zielgerichtete Diagnostik: Klinik, radiologisches Bild in Kombination mit dem mikrobiologischen Keimnachweis und das histologische Bild eines Infektes. Risikofaktoren und Eintrittspforten für Keime sollten minimiert werden. Die Infektsanierung besteht zunächst aus Entfernung aller Fremdmaterialen, radikalem chirurgischmn Debridement von avitalen Knochen- und Weichteilen in Kombination mit systemischer und ggf. lokaler Antibiotikagabe. Im 2. Schritt folgt die Rekonstruktion mit osteosynthetischer Stabilisierung, Kochen- und Weichteilrekonstruktion. Die Therapie wird an den Patienten individuell angepasst und kann stark variieren je nach Lokalisation, Keimen, Risikofaktoren, Alter, Kooperationsfähigkeit etc. und erfordert daher ein interdisziplinäres Team.
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Literatur
Babiak I (2014) Open tibial fractures grade IIIC treated successfully with external fixation, negative-pressure wound therapy and recombinant human bone morphogenetic protein 7. Int Wound J 11:476–482
Berbari E, Mabry T, Tsaras G et al. (2010) Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am 92:2102–2109
Bhandari M, Schemitsch EH, Adili A et al. (1999) High and low pressure pulsatile lavage of contaminated tibial fractures: an in vitro study of bacterial adherence and bone damage. J Orthop Trauma 13:526–533
Boyd JI3rd, Wongworawat MD (2004) High-pressure pulsatile lavage causes soft tissue damage. Clin Orthop Relat Res :13–17
Calori GM, Phillips M, Jeetle S et al. (2008) Classification of non-union: need for a new scoring system? Injury 39(Suppl 2):S59–S63
Celsus AC (1935) De Medicina. Loeb Classical Library 1935
Chen CE, Ko JY, Pan CC (2005) Results of vancomycin-impregnated cancellous bone grafting for infected tibial nonunion. Arch Orthop Trauma Surg 125:369–375
Cierny G 3rd, Mader JT, Pennick JJ (1985) A clinical staging system of adult osteomyelitis. Contemp Orthop 10:17–37
Deng Z, Cai L, Jin W, Ping A, Wei R (2014) One-stage reconstruction with open bone grafting and vacuum-assisted closure for infected tibial non-union. Arch Med Sci 10:764–772
Investigators FLOW, Bhandari M, Jeray KJ, Petrisor BA, Devereaux PJ, Heels-Ansdell D, Schemitsch EH, Anglen J, Della Rocca GJ, Jones C, Kreder H, Liew S, McKay P, Papp S, Sancheti P, Sprague S, Stone TB, Sun X, Tanner SL, Tornetta P 3rd, Tufescu T, Walter S, Guyatt GH et al. (2015) A trial of wound irrigation in the initial management of open fracture wounds. N Engl J Med 373(27):2629–2641. doi:10.1056/NEJMoa1508502.
Frommelt L (2006) Principles of systemic antimicrobial therapy in foreign material associated infection in bone tissue, with special focus on periprosthetic infection. Injury 37(Suppl 2):S87–S94
Gallo J, Kolar M, Dendis M et al. (2008) Culture and PCR analysis of joint fluid in the diagnosis of prosthetic joint infection. New Microbiol 31:97–104
Gerlach UJ, Schmidt H, Fuchs S et al. (2012) Pseudarthrosen und Infektionen proximaler Oberschenkel. Trauma Berufskrankh 4:482–486
Giannoudis PV, Einhorn TA, Marsh D (2007) Fracture healing: the diamond concept. Injury 38(Suppl 4):S3–S6
Gille J, Wallstabe S, Schulz AP et al. (2012) Is non-union of tibial shaft fractures due to nonculturable bacterial pathogens? A clinical investigation using PCR and culture techniques. J Orthop Surg Res 7:20
Hackl S, Glowalla C, Woltmann A et al. (2014) Low-grade infection in the pathogenesis of tibia-shaft nonunion. 7. Kongress für Orthopädie und Unfallchirurgie (DKOU 2014) [http://www.egms.de/static/en/meetings/dkou2014/14dkou167. shtml :
Heppert V, Wagner C, Scherf K, Wentzensen A (2005) Infekt-/Defektpseudarthrose, 7. Aufl. Springer, Berlin Heidelberg New York
Hou Z, Irgit K, Strohecker KA, Matzko ME, Wingert NC, DeSantis JG, Smith WR (2011) Delayed flap reconstruction with vacuum-assisted closure management of the open IIIB tibial fracture. J Trauma 71:1705–1708
Jain AK, Sinha S (2005) Infected nonunion of the long bones. Clin Orthop Relat Res :57–65
Johnson KD (1987) Management of malunion and nonunion of the tibia. Orthop Clin North Am 18:157–171
Josten C, Marquass B, Schwarz C, Verheyden A (2010) Intramedullary nailing of proximal tibial fractures. Complications and risk factors. Unfallchirurg 113:21–28
Karargyris O, Polyzois VD, Karabinas P, Mavrogenis AF, Pneumaticos SG (2014) Papineau debridement, Ilizarov bone transport, and negative-pressure wound closure for septic bone defects of the tibia. Eur J Orthop Surg Traumatol 24:1013–1017
Kunze H, Kramer D (1969) Local antibiotic and enzymatic therapy of chronic osteomyelitis. Med Klin 64:1608–1610
Larsen LH, Lange J, Xu Y, Schonheyder HC (2012) Optimizing culture methods for diagnosis of prosthetic joint infections: a summary of modifications and improvements reported since 1995. J Med Microbiol 61:309–316
Levine BR, Evans BG (2001) Use of blood culture vial specimens in intraoperative detection of infection. Clin Orthop Relat Res :222–231
Lucke M, Wildemann B, Sadoni S et al. (2005) Systemic versus local application of gentamicin in prophylaxis of implant-related osteomyelitis in a rat model. Bone 36:770–778
Macey LR, Kana SM, Jingushi S et al. (1989) Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am 71:722–733
Maharajan K, Patro DK, Menon J et al. (2013) Serum Procalcitonin is a sensitive and specific marker in the diagnosis of septic arthritis and acute osteomyelitis. J Orthop Surg Res 8:19
Masquelet AC, Begue T (2010) The concept of induced membrane for reconstruction of long bone defects. Orthop Clin North Am 41:27–37
McKee MD, Li-Bland EA, Wild LM, Schemitsch EH (2010) A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma 24:483–490
Megas P, Saridis A, Kouzelis A et al. (2010) The treatment of infected nonunion of the tibia following intramedullary nailing by the Ilizarov method. Injury 41:294–299
Metsemakers WJ, Reul M, Nijs S (2015) The use of gentamicin-coated nails in complex open tibia fracture and revision cases: A retrospective analysis of a single centre case series and review of the literature. Injury 46(12):2433–2437. doi:10.1016/j.injury.2015.09.028.
Militz M, Hackl S, Hungerer S et al. (2014) Infektpseudarthrosen – Wann werden wir aktiv? Trauma Berufskrankh 16(Suppl 4):444–451
Militz M, Weidemann H, la Fougère C (2012) Positronenemissionstomographie-Computertomographie (PET-CT) – Indikation bei Osteitis. Trauma Berufskrankh 14:16–20
Moghaddam A, Zimmermann G, Hammer K et al. (2011) Cigarette smoking influences the clinical and occupational outcome of patients with tibial shaft fractures. Injury 42:1435–1442
Motsitsi NS (2008) Management of infected nonunion of long bones: the last decade (1996–2006). Injury 39:155–160
Pandey R, Berendt AR, Athanasou NA (2000) Histological and microbiological findings in non-infected and infected revision arthroplasty tissues. The OSIRIS Collaborative Study Group. Oxford Skeletal Infection Research and Intervention Service. Arch Orthop Trauma Surg 120:570–574
Panousis K, Grigoris P, Butcher I et al. (2005) Poor predictive value of broad-range PCR for the detection of arthroplasty infection in 92 cases. Acta Orthop 76:341–346
Patel RA, Wilson RF, Patel PA, Palmer RM (2013) The effect of smoking on bone healing: A systematic review. Bone Jt Res 2:102–111
Patzakis MJ, Zalavras CG (2005) Chronic posttraumatic osteomyelitis and infected nonunion of the tibia: current management concepts. J Am Acad Orthop Surg 13:417–427
Podleska LE, Lendemans S, Schmid E et al. (2012) Sample taking during orthopedic surgery: sensitivity and specificity using the BACTEC blood culture system. Eur J Clin Microbiol Infect Dis 31:201–206
Pozo JL, Powell B, Andrews BG et al. (1990) The timing of amputation for lower limb trauma. J Bone Joint Surg Br 72:288–292
Rather LJ (1971) Disturbance of function (functio laesa): the legendary fifth cardinal sign of inflammation, added by Galen to the four cardinal signs of Celsus. Bull N Y Acad Med 47:303–322
Robinson D, On E, Hadas N et al. (1989) Microbiologic flora contaminating open fractures: its significance in the choice of primary antibiotic agents and the likelihood of deep wound infection. J Orthop Trauma 3:283–286
Schmidmaier G, Lucke M, Wildemann B et al. (2006) Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: a review. Injury 37(Suppl 2):S105–S112
Schmidt HG, Tiemann AH, Braunschweig R et al. (2011) Definition of the Diagnosis Osteomyelitis-Osteomyelitis Diagnosis Score (ODS). Z Orthop Unfallchir 149:449–460
Shroeder JE, Mosheiff R, Khoury A et al. (2009) The outcome of closed, intramedullary exchange nailing with reamed insertion in the treatment of femoral shaft nonunions. J Orthop Trauma 23:653–657
Simpson AH, Wood MK, Athanasou NA (2002) Histological assessment of the presence or absence of infection in fracture non-union. Injury 33:151–155
Slatis P, Paavolainen P (1985) External fixation of infected non-union of the femur. Injury 16:599–604
Somanchi BV, Khan S (2008) Vacuum-assisted wound closure (VAC) with simultaneous bone transport in the leg: a technical note. Acta Orthop Belg 74:538–541
Stannard JP, Volgas DA, Stewart R, McGwin G Jr, Alonso JE (2009) Negative pressure wound therapy after severe open fractures: a prospective randomized study. J Orthop Trauma 23:552–557
Steinhausen E, Glombitza M, Bohm HJ et al. (2013) Non-unions. From diagnosis to healing. Unfallchirurg 116:633–647
Stewart S, Barr S, Engiles J et al. (2012) Vancomycin-modified implant surface inhibits biofilm formation and supports bone-healing in an infected osteotomy model in sheep: a proof-of-concept study. J Bone Joint Surg Am 94:1406–1415
Struijs PA, Poolman RW, Bhandari M (2007) Infected nonunion of the long bones. J Orthop Trauma 21:507–511
Tonnesen PA, Heerfordt J, Pers M (1975) 150 open fractures of the tibial shaft--the relation between necrosis of the skin and delayed union. Acta Orthop Scand 46:823–835
Trampuz A, Widmer AF (2006) Infections associated with orthopedic implants. Curr Opin Infect Dis 19:349–356
Uckay I, Hoffmeyer P, Lew D, Pittet D (2013) Prevention of surgical site infections in orthopaedic surgery and bone trauma: state-of-the-art update. J Hosp Infect 84:5–12
Virolainen P, Lahteenmaki H, Hiltunen A et al. (2002) The reliability of diagnosis of infection during revision arthroplasties. Scand J Surg 91:178–181
Wagner C, Obst U, Hansch GM (2005) Implant-associated posttraumatic osteomyelitis: collateral damage by local host defense? Int J Artif Organs 28:1172–1180
Wagner C, Hansch GM, Wentzensen A, Heppert V (2006) Implant-associated post-traumatic osteomyelitis. Bacterial biofilms and the immune defence as protagonists of the local inflammatory process. Unfallchirurg 109:761–769
Zmistowski B, Della VC, Bauer TW et al. (2014) Diagnosis of periprosthetic joint infection. J Orthop Res 32(Suppl 1):98–107
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Hungerer, S., Morgenstern, M., Militz, M., Bühren, V. (2017). Infizierte Pseudarthrose. In: Biberthaler, P., van Griensven, M. (eds) Knochendefekte und Pseudarthrosen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-44991-8_8
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