Correlated Inhibitory Firing and Spike-Timing-Dependent Plasticity
Cortical inhibition by γ-aminobutyric acid (GABA) has been widely suggested to be required to trigger ocular dominance (OD) plasticity in the visual cortex. However, there is also evidence that only the circuits mediated by specific GABAA receptors can induce OD plasticity, which implies the importance of localized GABA circuits in this process. In this study, to investigate the role of local inhibition in visual plasticity, we simulated the synaptic dynamics regulated by lateral and backward inhibition. The lateral inhibition facilitated competitive interactions between different groups of excitatory correlated inputs, which were required to elicit experience-dependent synaptic modifications. Conversely, the backward inhibition suppressed such competitive interactions, which prevented synapses from reflecting past sensory experience. Our results suggest that the interactions between lateral and backward inhibition may regulate the timing and level of cortical plasticity by modulating the activity-dependent competitive function.
KeywordsSTDP GABA inhibition Firing correlation Synaptic competition Visual cortex
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- 9.Bi, G.Q., Poo, M.M.: Synaptic modifications in cultured hippocampal neurons: Dependence on spike timing, synaptic strength, and postsynaptic cell type. J. Neurosci. 18, 10464–10472 (1998)Google Scholar
- 10.Sakurai, I., Kubota, S., Niwano, M.: A model for ocular dominance plasticity controlled by feedforward and feedback inhibition (submitted)Google Scholar
- 15.Antonini, A., Gillespie, D.C., Crair, M.C., Stryker, M.P.: Morphology of single geniculocortical afferents and functional recovery of the visual cortex after reverse monocular deprivation in the kitten. J. Neurosci. 18, 9896–9909 (1998)Google Scholar
- 17.Kuhlman, S.J., Lu, J., Lazarus, M.S., Huang, Z.J.: Maturation of GABAergic inhibition promotes strengthening of temporally coherent inputs among convergent pathways. PLoS Comput. Biol. 6, e1000797 (2010)Google Scholar