Abstract
This study focuses on the effects of artificial cardiac tissue in the excitation-contraction process of the ventricular muscle. We developed a spatio-temporal computerized model of the whole heart that handles half millimeter sized compartments using 1 microsecond time step. We employed the effect of muscle fiber direction, laminar sheets, depolarization period and other parameters. The artificial tissue differs from the normal one in several ways, so their describing parameters are also modified. In our simulation the depolarization wave (DW) conduction speed of the artificial tissue was decreased by up to 3 times. In presence of a two centimeter wide and 2 mm thick artificial tissue slice, the maximal depolarization delay was 38 msec. Large ventricle size, low conducting speed and spaciousness of the injured ventricular tissue are the main generating factors of arrhythmia, while the location of the artificial tissue has secondary importance.
This work has been funded by the Scientific Exchange Program NMS-CH, “Rou: Swiss Research Fellowships”, Project code 12031.
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Szilágyi, S.M., Szilágyi, L., Hirsbrunner, B. (2013). Study of Electric and Mechanic Properties of the Implanted Artificial Cardiac Tissue Using a Whole Heart Model. In: Ruiz-Shulcloper, J., Sanniti di Baja, G. (eds) Progress in Pattern Recognition, Image Analysis, Computer Vision, and Applications. CIARP 2013. Lecture Notes in Computer Science, vol 8259. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41827-3_29
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DOI: https://doi.org/10.1007/978-3-642-41827-3_29
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