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Biological Network Modeling and Analysis

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Book cover Approaches in Integrative Bioinformatics

Abstract

Each scientist needs to be aware of the complexity of cellular life and the modeling possibilities to be able to reconstruct, analyze, and simulate biological systems. Bioinformatics modeling, analysis, and simulation are highly interdisciplinary disciplines using techniques and concepts from computer science, statistics, mathematics, chemistry, biology, biochemistry, genetics, and physics, among others. Without knowledge about these research topics, it is almost impossible to produce good theoretical models, which can be used for hypothesis testing. Therefore, this chapter gives an impression of what can be modeled from the bioinformatics and biological point of view and introduces into biological networks, common analysis techniques from graph theory, and possibilities to reconstruct, simulate, and share biological networks based on database content.

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Notes

  1. 1.

    The number of software applications has been approximated by counting software tools that support SBML and CellML. Software tools are listed at http://www.sbml.org/ and http://www.cellml.org/

  2. 2.

    http://sbml.org/

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Authors and Affiliations

  1. Faculty of Technology, Department of Bioinformatics, Bielefeld University, Universitätsstraße 25, D-33501, Bielefeld, Germany

    Sebastian Jan Janowski

  2. Faculty of Biology, Molecular Neurobiology, Bielefeld University, Universitätsstraße 25, D-33501, Bielefeld, Germany

    Barbara Kaltschmidt

  3. Faculty of Biology, Cell Biology, Bielefeld University, Universitätsstraße 25, D-33501, Bielefeld, Germany

    Christian Kaltschmidt

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  1. Sebastian Jan Janowski
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  2. Barbara Kaltschmidt
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  3. Christian Kaltschmidt
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Correspondence to Sebastian Jan Janowski .

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Editors and Affiliations

  1. College of Life Sciences, Zhejiang University, Hangzhou, People's Republic of China

    Ming Chen

  2. Department of Bioinformatics and Medical Informatics, Bielefeld University, Bielefeld, Germany

    Ralf Hofestädt

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Janowski, S.J., Kaltschmidt, B., Kaltschmidt, C. (2014). Biological Network Modeling and Analysis. In: Chen, M., Hofestädt, R. (eds) Approaches in Integrative Bioinformatics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41281-3_8

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