Abstract
Mastocytosis is characterized by the increase and accumulation of mast cells in the skin and visceral organs. The etiopathogenesis of the proliferation of mast cells is not known, but it has been suggested that mastocytosis is a clonal disease. Mast cells are among the cells of the dermis, but they may also be seen in different organs. They play an important role in type 1 hypersensitivity reactions owing to their rich supply of different intracytoplasmic mediators, especially histamine. The disease can be classified as cutaneous and systemic mastocytosis, according to the locations of the proliferated cells. Cutaneous mastocytosis is more common. In general, the skin is the most commonly involved site in mastocytosis, and most patients are diagnosed at dermatology clinics. Bone marrow, bones, the gastrointestinal system, liver, spleen, lymph nodes, and any site other than the central nerve system can be involved. Occurrence of mastocytosis is mostly sporadic and rarely familial.
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Baykal, C., Yazganoğlu, K.D. (2014). Mastocytosis. In: Clinical Atlas of Skin Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40938-7_9
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DOI: https://doi.org/10.1007/978-3-642-40938-7_9
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