Abstract
We describe an investigation into spatial modelling by means of an ongoing case study, namely phase variation patterning in bacterial colony growth, forming circular colonies on a flat medium. We explore the application of two different geometries, rectangular and circular, for modelling and analysing the colony growth in 2.5 dimensions. Our modelling paradigm is that of coloured stochastic Petri nets and we employ stochastic simulation in order to generate output which is then analysed for sector patterning. The analysis results are used to compare the two geometries, and our multidimensional approach is a precursor to more work on detailed multiscale modelling.
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Pârvu, O., Gilbert, D., Heiner, M., Liu, F., Saunders, N. (2013). Modelling and Analysis of Phase Variation in Bacterial Colony Growth. In: Gupta, A., Henzinger, T.A. (eds) Computational Methods in Systems Biology. CMSB 2013. Lecture Notes in Computer Science(), vol 8130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40708-6_7
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DOI: https://doi.org/10.1007/978-3-642-40708-6_7
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