MRI and In Vivo Spectroscopy of the Brain

  • Alessandro BurlinaEmail author
  • Renzo Manara


Magnetic resonance is an essential tool to study brain diseases. Even though the diagnosis of inherited metabolic diseases is achieved by means of biochemical and genetic tools, brain magnetic resonance imaging (MRI) is useful for detecting brain complications (i.e., stroke-like episodes for propionic acidemia or MELAS) and for the follow-up of brain lesions load (i.e., white matter abnormalities in Fabry disease). In specific diseases, like Canavan disease and creatine deficiency syndromes (AGAT deficiency and creatine transporter defects), diagnosis can be made with in vivo proton magnetic resonance spectroscopy (MRS).


Magnetic Resonance Spectroscopy Fabry Disease White Matter Abnormality Glutaric Aciduria Type Canavan Disease 
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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Neurology UnitSt. Bassiano HospitalBassano del GrappaItaly
  2. 2.NeuroradiologyUniversity of SalernoBaronissiItaly

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