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Pharmacologic Vitreolysis: Clinical Trial Data

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Diseases of the Vitreo-Macular Interface

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Pharmacologic vitreolysis refers to the administration of an agent to induce vitreous liquefaction and/or vitreoretinal separation in an attempt to treat vitreoretinal disorders. Enzymes that target one or more of the substrates that make up the vitreous and/or the “molecular glue” at the vitreoretinal interface have received the most attention in the search for a safe and effective pharmacologic vitreolytic agent. Although there is currently no pharmacologic therapy approved for treatment of diseases of the vitreo-macular interface, encouraging clinical results have been reported in recent years. The results of available clinical evaluations of the following agents are discussed in this chapter: collagenase, hyaluronidase, vitreosolve, tissue plasminogen activator, plasmin, and ocriplasmin.

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Authors and Affiliations

  1. Clinical Development, Amakem NV, 15 Lewis Rd, Irvington, NY, 10533, USA

    Steve Pakola MD

  2. Wills Eye Institute, 840 Walnut Street, Suite 1510, Philadelphia, PA, 19107, USA

    Julia A. Haller MD

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  1. Steve Pakola MD
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  2. Julia A. Haller MD
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Correspondence to Steve Pakola MD .

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Editors and Affiliations

  1. ThromboGenics NV, Leuven, Belgium

    Aniz Girach

  2. Clinique de Montchoisi, Lausanne, Switzerland

    Marc D. de Smet

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Compliance with Ethical Requirements

Dr. Haller consults for the following companies: ThromboGenics, Second Sight, Advanced Cell Technology, Merck, Regeneron, KalVista, Genentech, and Alcon. She has equity in OptiMedica.

Dr. Pakola is a former employee of ThromboGenics Inc and has no other conflicts of interest.

No animal or human studies were carried out by the authors for this article.

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Pakola, S., Haller, J.A. (2014). Pharmacologic Vitreolysis: Clinical Trial Data. In: Girach, A., de Smet, M. (eds) Diseases of the Vitreo-Macular Interface. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40034-6_11

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  • DOI: https://doi.org/10.1007/978-3-642-40034-6_11

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