Pharmacologic Vitreolysis: Clinical Trial Data

Part of the Essentials in Ophthalmology book series (ESSENTIALS)


Pharmacologic vitreolysis refers to the administration of an agent to induce vitreous liquefaction and/or vitreoretinal separation in an attempt to treat vitreoretinal disorders. Enzymes that target one or more of the substrates that make up the vitreous and/or the “molecular glue” at the vitreoretinal interface have received the most attention in the search for a safe and effective pharmacologic vitreolytic agent. Although there is currently no pharmacologic therapy approved for treatment of diseases of the vitreo-macular interface, encouraging clinical results have been reported in recent years. The results of available clinical evaluations of the following agents are discussed in this chapter: collagenase, hyaluronidase, vitreosolve, tissue plasminogen activator, plasmin, and ocriplasmin.


Diabetic Retinopathy Tissue Plasminogen Activator Macular Hole Diabetic Macular Edema Proliferative Diabetic Retinopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Clinical Development, Amakem NVIrvingtonUSA
  2. 2.Wills Eye InstitutePhiladelphiaUSA

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