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Application of Fuzzy Logic Control for Regulation of Glucose Level of Diabetic Patient

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Machine Learning in Healthcare Informatics

Part of the book series: Intelligent Systems Reference Library ((ISRL,volume 56))

Abstract

Diabetes can lead to many complications. If a patient cannot control his or her glucose level properly, he or she may suffer serious consequences. The result may be ketosis, which is normally due to an increase of acetone (a toxic acid product) and may lead to a situation such as diabetic coma. A fuzzy logic control system for the regulation of glucose level for diabetic patients is proposed in this chapter. A mathematical model describing the relationship between the human glucose level, insulin, and food is first presented. Then, a generalized fuzzy logic controller, including a set of fuzzy logic rules, is introduced to regulate glucose levels for diabetic patients. Following the fuzzy logic controller, simulation is presented. The results show that the fuzzy logic control is effective for handling the glucose level based on feedback scheme.

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References

  1. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schietz M et al (2001) Intensive insulin therapy in critically ill patients. N Eng J Med 345(19):1359–1367

    Article  Google Scholar 

  2. American Diabetes Association (1998) Economic consequences of diabetes mellitus in the US in 1997. Diabetes Care 21(2):296–309

    Google Scholar 

  3. Thomson S, Beaven D, Jamieson M, Snively S, Howl A, Christophersen A (2001) Diabetes New Zealand Inc. Type II diabetes: managing for better health outcomes. PriceWaterHouseCoopers report

    Google Scholar 

  4. Chase JG, Lam ZH, Lee JY, Hwang KS (2002) Active insulin infusion control of the blood glucose derivative. In: Seventh international conference on control, automation, robotics and vision (ICARCV’02), Singapore, 2–5 Dec 2002

    Google Scholar 

  5. Kienitz K, Yoneyama T (1993) Robust controller for insulin pumps based on H-infinity theory. IEEE Trans Biomed Eng 38(1):57–61

    Google Scholar 

  6. Lam ZH, Hwang KS, Lee JY, Chase JG, Wake GC (2002) Active insulin infusion using optimal and derivative-weighted control. Med Eng Phy 24(10):663–672

    Article  Google Scholar 

  7. Bode B et al (2004) Alarms based on real-time sensor glucose values alert patients to hypo- and hyperglycemia: the guardian continuous glucose monitoring system. Diabetes Technol Ther 6(2):105–113

    Google Scholar 

  8. Bode BW et al (1999) Continuous glucose monitoring used to adjust diabetes therapy improves glycosylated hemoglobin: a pilot study. Diabetes Res Clin Pract 46:183–190

    Google Scholar 

  9. Kaufman FR et al (2001) A pilot study of the continuous glucose monitoring system: clinical decisions and glycemic control after its use in pediatric type 1 diabetic subjects. Diabetes Care 24(12):2030

    Google Scholar 

  10. Ludvigsson J, Hanas R (2003) Continuous subcutaneous glucose monitoring improved metabolic control in pediatric patients with type 1 diabetes: a controlled crossover study. Pediatrics 5(1):933–938

    Google Scholar 

  11. Derr R, Garrett E, Stacy G et al (2003) Is HbA1c affected by glycemic instability. Diabetes Care 26(10):2728–2733

    Article  Google Scholar 

  12. Lenhard MJ, Reeves GD (2001) Continuous subcutaneous insulin infusion: a comprehensive review of insulin pump therapy. Arch Intern Med 161(19):2293–2300

    Article  Google Scholar 

  13. Davies AG, Baun JD (1988) A decade of insulin infusion pumps. Arch Dis Child 63(3):329–332

    Article  Google Scholar 

  14. Mecklenburg R, Benson J, Becker N, Brazel P, Fredlund P, Metz R, Nielson R, Sanner C, Steenrod W (1982) Clinical use of the insulin infusion pump in 100 patients with type 1 diabetes. N Engl J Med 307(9):513–518

    Article  Google Scholar 

  15. Plotnick LP, Brancati FL, Clark LM, Erlinger T (2003) Safety and effectiveness of insulin pump therapy in children and adolescents with type I diabetes. Diabetes Care 26(4):1142–1146

    Article  Google Scholar 

  16. Doran CV, Chase JG, Shaw GM, Moorhead KT, Hudson NH (2005) Derivative weighted active insulin control algorithms and intensive care unit trials. Control Eng Pract 13(9):1129–1137

    Article  Google Scholar 

  17. Bergman RN, Finegood DT, Ader M (1985) Assessment of insulin sensitivity in vivo. Endocr Rev 6(1):45–86

    Article  Google Scholar 

  18. Kienitz K, Yoneyama T (1993) Robust controller for insulin pumps based on H-infinity theory. IEEE Trans Biomed Eng 40(11):1133–1137

    Article  Google Scholar 

  19. Cobelli C, Nucci G, DelPrato S (1999) Physiological simulation model of the glucose insulin system. In: IEEE conference on engineering in medicine and biology, Atlanta, Georgia, 13–16 Oct 1999

    Google Scholar 

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Correspondence to K. Y. Zhu .

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Zhu, K.Y., Liu, W.D., Xiao, Y. (2014). Application of Fuzzy Logic Control for Regulation of Glucose Level of Diabetic Patient. In: Dua, S., Acharya, U., Dua, P. (eds) Machine Learning in Healthcare Informatics. Intelligent Systems Reference Library, vol 56. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40017-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-40017-9_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-40016-2

  • Online ISBN: 978-3-642-40017-9

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