Abstract
Healthcare informatics, a multi-disciplinary field has become synonymous with the technological advancements and big data challenges. With the need to reduce healthcare costs and the movement towards personalized healthcare, the healthcare industry faces changes in three core areas namely, electronic record management, data integration, and computer aided diagnoses. Machine learning a complex field in itself offers a wide range of tools, techniques, and frameworks that can be exploited to address these challenges. This chapter elaborates on the intricacies of data handling the data rich filed of healthcare informatics, and the potential role of machine learning to mitigate the challenges faced.
Keywords
- Machine Learning
- Single Photon Emission Compute Tomography
- Electronic Health Record
- Pervasive Computing
- Unify Medical Language System
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, access via your institution.
Buying options



References
Zhang Y, Poon C (2010) Editorial note on bio, medical and health informatics. IEEE Trans Inf Technol Biomed 14(3):543–545
Hillestad R, Bigelow J, Bower A, Girosi F, Meili R, Scoville R, Taylor R (2005) Can electronic medical record systems transform healthcare? potential health benefits, savings, and costs. Health Aff 24(5):1103–1117
Chaudry B, Wang J, Wu S, Maglione M, Mojica W, Roth E, Morton S, Shekelle P (2006) Systematic review: impact of health information technology on quality, efficiency, and costs of medical care. Annal Internal Med 144, E-12-E-22
Clifton DA, Gibbons J, Davies J, Tarassenko L (2012) Machine learning and software engineering in health informatics. In: First international workshop on realizing artificial intelligence synergies in software engineering (RAISE), Zurich, Switzerland, 5 June 2012
Kerr W, Lau E, Owens G, Trefler A (2012) The future of medical diagnostics: large digitized databases. Yale J Biol Med 85(3):363–377
van Ginneken B, Schaefer-Prokop C, Prokop M (2011) Computer-aided diagnosis: how to move from the laboratory to the clinic. Radiology 261(3):719–732
Bedard N, Pierce M, El-Naggar A, Anandasabapathy S, Gillenwater A, Richards-Kortum R (2010) Emerging roles for multimodal optical imaging in early cancer detection: a global challenge. Technol Cancer Res Treat 9(2):211–217
Weissleder R, Pittet M (2008) Imaging in the era of molecular oncology. Nature 452:580–589
Pierce M, Javier D, Richards-Kortum R (2008) Optical contrast agents and imaging systems for detection and diagnosis of cancer. Int J Cancer 123:1979–1990
Massoud T, Gambhir S (2007) Integrating noninvasive molecular imaging into molecular medicine: an evolving paradigm. Trends Mol Med 13(5):183–191
Suzuki K, Yan P, Wang F, Shen D (2012) Machine learning in medical imaging. Int J Biomed Imaging: Article ID 123727
Richesson R, Nadkarni P (2011) Data standards for clinical research data collection forms: current status and challenges. J Am Med Inform Assoc 18(3):341–346
Oliver DE, Shahar Y, Shortliffe E, Musen M (1999) Representation of change in controlled medical terminologies. Artif Intell Med 15(1):53–76
Chismar W (2007) Introduction to the information technology in healthcare track. In: System sciences, 2007. HICSS 2007. 40th annual Hawaii international conference on, Waikoloa
Ammenwerth E, Gräber S, Herrmann G, Bürkle T, König J (2003) Evaluation of health information systems-problems and challenges. Int J Med Inform 71(2–3):125–135
Salih R, Othmane L, Lilien L (2011) Privacy protection in pervasive healthcare monitoring systems with active bundles. In: Parallel and distributed processing with applications workshops (ISPAW), 2011 ninth IEEE international symposium on, Busan, South Korea, 2011
Yakut I, Polat H (2012) Privacy-preserving hybrid collaborative filtering on cross distributed data. Knowl Inf Syst 30(2):405–433
World Medical Association (2008) WMA declaration of Helsinki - ethical principles for medical research involving human subjects. http://www.wma.net/en/30publications/10policies/b3/. Accessed 10 Feb 2013
Lanham H, Leykum L, McDaniel Jr. R (2012) Same organization, same electronic health records (EHRs) system, different use: exploring the linkage between practice member communication patterns and EHR use patterns in an ambulatory care setting. J Am Med Inform Assoc 19:382–391
Madabhushi A, Agner S, Basavanhally A, Doyle S, Lee G (2011) Computer-aided prognosis: predicting patient and disease outcome via quantitative fusion of mult-scale, multi-modal data. Comput Med Imaging Graph 35:506–514
Belle A, Kon M, Najarian K (2013) Biomedical informatics for computer-aided decision support sytems: a survey. Sci World J: Article ID 769639
El-Baz A, Beache G, Gimel’frab G, Suzuki K, Okada K, Elnakib A, Soliman A, Abdollahi B (2012) Computer-Aided diagnosis systems for lung cancer: challenges and methodologies. Int J Biomed Imaging: Article ID 942353
Poon CCY, Wang MD, Bonato P, Fenstermacher DA (2013) Editorial: special issue on health informatics and personalized medicine. Biomed Eng IEEE Trans 60(1):143–146
Fakruddin M, Hossain Z, Afroz H (2012) Prospects and applications fo nanobiotechnology: a medical perspective. J Nanobiotechnol 10(31):1–8
Calhoun B, Lach J, Stankovic J, Wentzloff D, Whitehouse K, Barth A, Brown J, Li Q, Oh S, Roberts N, Zhang Y (2012) Body sensor networks: a holistic approach from silicon to users. Proc IEEE 100(1):91–106
Halamka J, Mandl K, Tang P (2008) Early experiences with personal health records. J Am Med Infom Assoc 15:1–7
Ross S, Lin C (2003) The effects of promoting patient access to medical records: a review. J Am Med Inform Assoc 10:129–138
Hripcsak G, Cimino J, Sengupta S (1999) WebCIS: large scale deployment of a web-based clinical information system. In: Proceedings of AMIA symposium, Washington, DC
Liu Z, Chu W (2007) Knowledge-based query expansion to support scenario-specific retrieval of medical free text. Inf Retieval 10(2):173–202
Patel C, Cimino J, Dolby J, Fokoue A, Kalyanpur A, Kershenbaum A, Li M, Schonberg E, Srinivas K (2007) Matching patient records to clinical trials using ontologies. Semant Web 4825:816–829
Schloeffel P, Beale T, Hayworth G, Heard S, Leslie H (2006) The relationship between CEN 13606, HL7, and openEHR. In: HIC 2006 bridging the digital divide: clinician, consumer and computer, Australia, health informatics society of Australia Ltd (HISA)
Chen R, Klein G, Sundvall E, Karlsson D, Ahlfeldt H (2009) Archetyoe-based conversion of EHR content models: pilot experience with a regional EHR system. BMC Med Inform Decis Mak 9(33):1–13
Garde S, Knaup P, Hovenga E, Heard S (2007) Towards semantic interoperability for electronic health records: domain knowledge governance for openEHR archetypes. Methods Inf Med 46(3):332–343
Doi K (2007) Computer-Aided diagnosis in medical imaging: historical review, current status, and future potential. Comput Med Imaging Graph 31(4–5):198–211
Fayyad U, Piatetsky-Shapiro G, Smyth P (1996) The KDD process for extracting useful knowledge from volumes of data. Commun ACM 39(1):27–34
van Ginneken B, ter Haar Romeny B, Viergever M (2001) Computer-aided diagnosis in chest radiography: a survey. Med Imaging IEEE Trans 20(12):1228–1241
Schorfheide F, Wolpin K (2012) On the use of holdout samples for model selection. Am Econ Rev 102(3):477–481
Padilla P, Lopez M, Gorriz J, Ramirez J, Salas-Gonzalez D, Alvarez I (2012) Alzheimer’s Disease Neuroimaging Initiative NMF-SVM based CAD tool applied to functional brain images for the diagnosis of Alzheimer’s Disease. Med Imaging IEEE Trans 31(2):207–216
Dua S, Srinivasan P (2008) A non-voxel bsed feature extraction to detect cognitive states in fMRI. In: 30th annual international IEEE EMBS conference, Vancouver
Kamruzzaman J, Begg R, Sarker R (2006) Overview of artificial neural networks and their applications in healthcare. Neural Networks in Healthcare: Potential and Challenges, Idea Group Inc (IGI), pp 1
Michel V, Gramfort A, Varoquaux G, Eger E, Keribin C, Thirion B (2012) A supervised clustering approach for fMRI-based inference of brain states. Pattern Recogn 45(6):2041–2049
Lawhern V, Hairston W, McDowell K, Westerfield M, Robbins K (2012) Detection and classification of subject artifacts in EEG signals using autoregressive models. J Neurosci Methods 208(2):181–189
Schalk G, Brunner P, Gerhardt L, Bischof H, Wolpaw JR (2008) Brain–computer interfaces (BCIs): detection instead of classification. J Neurosci Methods 167(1):51–62
Majumdar K (2011) Human scalp EEG processing: various soft computing approaches. Appl Soft Comput 11(8):4433–4447
Ma Z, Tavares J, Jorge R, Mascarenhas T (2010) A review of algorithms for medical image segmentation and their applications to the female pelvic cavity. Comput Methods Biomech Biomed Eng 13(2):235–246
Peters J, Ecabert O, Meyer C, Kneser R, Weese J (2010) Optimizing boundary detection via simulated search with applications to multi-modal heart segmentation. Med Image Anal 14(1):70
Suk HI, Lee SW (2013) A novel bayesian framework for discriminative feature extraction in brain-computer interfaces. Pattern Anal Mach Learn IEEE Trans 35(2):286–299
Maulik U (2009) Medical image segmentation using genetic algorithms. Inf Technol Biomed IEEE Trans 13(2):166–173
McIntosh C, Hamarneh G (2011) Evolutionary deformable models for medical image segmentation: a genetic algorithm approach to optimizing learned, intuitive, and localized medial‐based shape deformation. In: Stephen L, Smith, Cagnoni S (eds) Genetic and evolutionary computation: Medical Applications, Wiley, pp 46–67
Varol E, Gaonkar B, Erus G, Schultz R, Davatzikos C (2012) Feature ranking based nested support vector machine ensemble for medical image classification. In: 9th IEEE international symposium on biomedical imaging (ISBI)
Fraz M, Remagnino P, Hoppe A, Uyyanonvara B, Rudnicka A, Owen C, Barman S (2012) An ensemble classification-based approach applied to retinal blood vessel segmentation. IEEE Trans Biomed Eng 59(9):2538–2548
Mansi T, Mihalef V, Sharma P, Georgescu B, Zheng X, Rapaka S, Kamen A, Mereles D, Steen H, Meder B, Katus H, Comaniciu D (2012) Data-driven computational models of heart anatomy, mechanics and hemodynamics: an integrated framework. In: 9th IEEE international symposium on biomedical imaging (ISBI)
Mao Y, Chen W, Chen Y, Lu C, Kollef M, Bailey T (2012) An integrated data mining approach to real-time clinical monitoring and deterioration warning. In: Proceedings of the 18th ACM SIGKDD international conference on Knowledge discovery and data mining (KDD ‘12), New York, NY, USA
Caceres C, Rikli A (2012) The digital computer as an aid in the diagnosis of cardiovascular disease. Transactions of the New York Academy of Science. 23(3 series II):240–245
Tracy K, Dykstra B, Gakenheimer D, Scheetz J, Lacina S, Scarfe W, Farman A (2011) Utility and effectiveness of computer-aided diagnosis of dental caries. Gen Dent 59(2):136–144
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Chowriappa, P., Dua, S., Todorov, Y. (2014). Introduction to Machine Learning in Healthcare Informatics. In: Dua, S., Acharya, U., Dua, P. (eds) Machine Learning in Healthcare Informatics. Intelligent Systems Reference Library, vol 56. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40017-9_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-40017-9_1
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-40016-2
Online ISBN: 978-3-642-40017-9
eBook Packages: EngineeringEngineering (R0)