Neonatal Hypertension

  • René G. VanDeVoorde
  • Mark M. MitsnefesEmail author


Since its first cited description in the 1970s [2], there has been a greater awareness of neonatal hypertension amongst neonatologists and pediatric nephrologists. Advances have been made in the ability to accurately assess blood pressure (BP) in neonates as well as increased knowledge of normal BP values and trends in newborns with lower birth weights and shorter gestational age, thus allowing better identification of neonates who are at risk for hypertension. Despite progress in these areas, there are others (pathogenesis, threshold for treatment, comparative trials of therapies) that have advanced much more slowly. Fortunately, overall outcomes in neonates with hypertension remain very good.


Renal Artery Stenosis Congenital Adrenal Hyperplasia Chronic Lung Disease Renovascular Hypertension Aortic Coarctation 
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  1. 1.
    Abman SH, Warady BA, Lum GM et al (1982) Systemic hypertension in infants with bronchopulmonary dysplasia. J Pediatr 104:928–931CrossRefGoogle Scholar
  2. 2.
    Adelman RD (1978) Neonatal hypertension. Pediatr Clin North Am 25:99–110PubMedGoogle Scholar
  3. 3.
    Adelman RD (1987) Long-term follow-up of neonatal renovascular hypertension. Pediatr Nephrol 1:35–41CrossRefPubMedGoogle Scholar
  4. 4.
    Adelman RD (1988) The hypertensive neonate. Clin Perinatol 15:567–585PubMedGoogle Scholar
  5. 5.
    Alagappan A, Malloy MH (1998) Systemic hypertension in very low-birth weight infants with bronchopulmonary dysplasia: incidence and risk factors. Am J Perinatol 15(1):3–8CrossRefPubMedGoogle Scholar
  6. 6.
    American Academy of Pediatrics Committee on Fetus and Newborn (1993) Routine evaluation of blood pressure, hematocrit, and glucose in newborns. Pediatrics 92:474–476Google Scholar
  7. 7.
    Anderson AH, Warady BA, Daily DK et al (1993) Systemic hypertension in infants with severe bronchopulmonary dysplasia: associated clinical factors. Am J Perinatol 10(3):190–193PubMedGoogle Scholar
  8. 8.
    Barrington KJ (2010) Umbilical artery catheters in the newborn: effects of position of the catheter tip. Cochrane Database Syst Rev 1:CD 000505. doi: 10.102/14658188 Google Scholar
  9. 9.
    Blowey DL, Duda PJ, Stokes P et al (2011) Incidence and treatment of hypertension in the neonatal intensive care unit. J Am Soc Hypertens 5:478–483CrossRefPubMedGoogle Scholar
  10. 10.
    Buchi KF, Siegler RL (1986) Hypertension in the first month of life. J Hypertens 4(5):525–528CrossRefPubMedGoogle Scholar
  11. 11.
    Butt WW, Whyte H (1984) Blood pressure monitoring in neonates: comparison of umbilical and peripheral artery catheter measurements. J Pediatr 105(4):630–632CrossRefPubMedGoogle Scholar
  12. 12.
    Cachat F, Van Melle G, McGahren ED et al (2006) Arterial hypertension after surgical closure of omphalocele and gastroschisis. Pediatr Nephrol 21(2):225–229CrossRefPubMedGoogle Scholar
  13. 13.
    DeSwiet M, Fayers P, Shinebourne EA (1976) Blood pressure survey in a population of newborn infants. BMJ 2:9–11CrossRefGoogle Scholar
  14. 14.
    DeSwiet M, Fayers P, Shinebourne EA (1980) Systolic blood pressure in a population of infants in the first year of life: the Brompton Study. Pediatrics 65:1028–1035Google Scholar
  15. 15.
    Dionne JM, Abitbol CL, Flynn JT (2012) Hypertension in infancy: diagnosis, management and outcome. Pediatr Nephrol 27(1):17–32CrossRefPubMedGoogle Scholar
  16. 16.
    Dionne JM, Abitbol CL, Flynn JT (2012) Erratum to: Hypertension in infancy: diagnosis, management and outcome. Pediatr Nephrol 27(1):159–160CrossRefGoogle Scholar
  17. 17.
    Dweck HS, Reynolds DW, Cassady G (1974) Indirect blood pressure measurements in newborns. Am J Dis Child 127:492–494PubMedGoogle Scholar
  18. 18.
    Feld GF, Waz WR (1997) Pharmacologic therapy of hypertension. In: Feld GF (ed) Hypertension in children. Butterworth-Heinemann, BostonGoogle Scholar
  19. 19.
    Friedman AL, Hustead VA (1987) Hypertension in babies following discharge from a neonatal intensive care unit. Pediatr Nephrol 1:30–34CrossRefPubMedGoogle Scholar
  20. 20.
    Friesen RH, Lichtor JL (1981) Indirect measurement of blood pressure in neonates and infants utilizing an automatic non-invasive oscillometric monitor. Anesth Analg 60(10):742–745CrossRefPubMedGoogle Scholar
  21. 21.
    Gemelli M, Manganaro R, Mami C et al (1990) Longitudinal study of blood pressure during the first year of life. Eur J Pediatr 149:318–320CrossRefPubMedGoogle Scholar
  22. 22.
    Gouyon JB, Geneste B, Semana DS et al (1997) Intravenous nicardipine in hypertensive preterm infants. Arch Dis Child 76:F126–F127CrossRefGoogle Scholar
  23. 23.
    Guay-Woodford LM, Desmond RA (2003) Autosomal recessive polycystic kidney disease: the clinical experience in North America. Pediatrics 111(5 Pt 1):1072–1080CrossRefPubMedGoogle Scholar
  24. 24.
    Husmann DA, McLorie GA, Churchill BM (1993) Hypertension following primary bladder closure for vesical exstrophy. J Pediatr Surg 28(2):239–241CrossRefPubMedGoogle Scholar
  25. 25.
    Kent AL, Kecskes Z, Shadbolt B et al (2007) Normative blood pressure data in the early neonatal period. Pediatr Nephrol 22(9):1335–1341CrossRefPubMedGoogle Scholar
  26. 26.
    Lanzarini VV, Furusawa EA, Sadeck L et al (2006) Neonatal arterial hypertension in nephrological malformations in a tertiary care hospital. J Hum Hypertens 20:679–683CrossRefPubMedGoogle Scholar
  27. 27.
    Lum LG, Jones MD (1977) The effect of cuff width on systolic blood pressure measurements in neonates. J Pediatr 91:963–966CrossRefPubMedGoogle Scholar
  28. 28.
    Lurbe E, Garcia-Vicent C, Torro I et al (2007) First-year blood pressure increase steepest in low birthweight newborns. J Hypertens 25:81–86CrossRefPubMedGoogle Scholar
  29. 29.
    Milou C, Debuche-Benouachkou V, Semana DS et al (2000) Intravenous nicardipine as a first-line antihypertensive drug in neonates. Intensive Care Med 26:956–958CrossRefPubMedGoogle Scholar
  30. 30.
    Nafday SM, Brion LP, Benchimol C et al (2005) Renal disease. In: McDonald MB, Mullett MD, Seshia MMK (eds) Avery’s neonatology, 6th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  31. 31.
    National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 114:555–576CrossRefGoogle Scholar
  32. 32.
    Nwankwo MU, Lorenz JM, Gardiner JC (1997) A standard protocol for blood pressure measurement in the newborn. Pediatrics 99(6):e10CrossRefPubMedGoogle Scholar
  33. 33.
    O’Shea J, Dempsey EM (2009) A comparison of blood pressure in newborns. Am J Perinatol 26(2):113–116CrossRefPubMedGoogle Scholar
  34. 34.
    O’Sullivan JJ, Derrick G, Darnell R (2002) Prevalence of hypertension in children after early repair of coarctation of the aorta: a cohort study using casual and 24 hour blood pressure measurement. Heart 88:163–166CrossRefPubMedCentralPubMedGoogle Scholar
  35. 35.
    Pejovic B, Peco-Antic A, Marinkovic-Eric J (2007) Blood pressure in non-critically ill preterm and full-term neonates. Pediatr Nephrol 22:249–257CrossRefPubMedGoogle Scholar
  36. 36.
    Piazza SF, Chandra M, Harper RG et al (1985) Upper vs lower limb systolic blood pressure in full term normal newborn. Am J Dis Child 139:797–799PubMedGoogle Scholar
  37. 37.
    Seilem WA, Falk MC, Shadbolt B et al (2007) Antenatal and postnatal risk factors for neonatal hypertension and infant follow-up. Pediatr Nephrol 22:2081–2087CrossRefGoogle Scholar
  38. 38.
    Singh HP, Hurley RM, Myers TF (1992) Neonatal hypertension. Incidence and risk factors. Am J Hypertens 5(2):51–55PubMedGoogle Scholar
  39. 39.
    Skalina MEL, Kliegman RM, Fanaroff AA (1986) Epidemiology and management of severe symptomatic neonatal hypertension. Am J Perinatol 3:235–239CrossRefPubMedGoogle Scholar
  40. 40.
    Sonesson SE, Broberger U (1987) Arterial blood pressure in the very low birthweight neonate. Evaluation of an oscillometric technique. Acta Paediatr Scand 76(2):338–341CrossRefPubMedGoogle Scholar
  41. 41.
    Stephenson TJ, Broughton Pipkin F, Elias-Jones AC (1991) Factors influencing plasma renin and renin substrate in premature infants. Arch Dis Child 66:1150–1154CrossRefPubMedCentralPubMedGoogle Scholar
  42. 42.
    Takci S, Yigit S, Korkmaz A et al (2012) Comparison between oscillometric and invasive blood pressure measurements in critically ill premature infants. Acta Paediatr 101:132–135CrossRefPubMedGoogle Scholar
  43. 43.
    Thomas CA, Moffett BS, Wagner JL et al (2011) Safety and efficacy of intravenous labetalol for hypertensive crisis in infants and small children. Pediatr Crit Care Med 12(1):28–32CrossRefPubMedGoogle Scholar
  44. 44.
    Wareham JA, Haugh LD, Yaeger SB et al (1987) Prediction of arterial blood pressure in the premature neonate using the oscillometric method. Am J Dis Child 141(10):1108–1110PubMedGoogle Scholar
  45. 45.
    Wells TG, Bunchman TE, Kearns GL (1990) Treatment of neonatal hypertension with enalaprilat. J Pediatr 117:664–667CrossRefPubMedGoogle Scholar
  46. 46.
    Zubrow AB, Hulman S, Kushner H et al (1995) Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. Philadelphia Neonatal Blood Pressure Study Group. J Perinatol 15(6):470–479PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Nephrology and HypertensionCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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