Abstract
Skin is the largest organ of the human body. Usually, it is easy accessible for topical application of drugs and light dosimetry is easy due to the rather flat appearance in a first approximation. On the other hand a larger number of skin diseases cover a larger area or show multifocal appearance, which favors regional or large field therapies and impedes surgical interventions. As scar formation is another and today highly unwanted result of surgery, the widespread use of PDT in dermatology is a necessary consequence.
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von Tappeiner H (1900) Ueber die Wirkung fluorescierende Stoffe auf Infusiorien nach Versuchen von O Raab. Munch Med Wochenschr 47:5
Raab O (1900) Ueber die Wirkung Fluorescierender Stoffe auf Infusorien. Z Biol 39:524–546
Tappeiner H von, Jodlbauer A (1907) Die Sensibilisierende Wirkung Fluorescierender Substanzen. Untersuchungen über die Photodynamische Erscheinung FCW, Vogel Leipzig
Hausmann W (1911) Die sensibilisierende Wirkung des Hamatoporphyrins. Biochem Z 30:276–316
Meyer-Betz F (1913) Untersuchungen über die Biologische (photodynamische) Wirkung des Hamatoporphyrins und anderer Derivative des Blut- und Gallenfarbstoffs. Dtsch Arch Klein Med 112:476–503
von Tappeiner H, Jesionek A (1903) Therapeutische Versuche mit fluorescierenden Stoffen. Munch Med Wochenschr 47:2042–2044
Jesionek A, von Tappeiner H (1905) Zur Behandlung der Hautcarcinome mit fluorescierenden Stoffen. Arch Klin Med 82:223
Divaris DX, Kennedy JC, Pottier RH (1990) Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 4-aminoevulinic acid correlates with localized protoporphyrin IX fluorescence. Am J Pathol 136:891–897
Kennedy JC, Pottier RH, Pross DC (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol, B 6:143–148
Collaud S, Juzenziene A, Lange N (2004) On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation. Curr Med Chem Anticancer Agents 4:301–316
Hinnen P, de Rooij FW, van Velthuysen ML, Edixhoven A, van Hillegersberg R, Tilanus HW, Wilson JH, Siersema PD (1998) Biochemical basis of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation: a study in patients with (pre)malignant lesions of the oesophagus. Br J Cancer 78:679–682
Krieg RC, Fickweiler S, Wolfbeis OS, Knuechel R (2000) Cell-type specific protoporphyrin IX metabolism in human bladder cancer in vitro. Photochem Photobiol 72:226–233
Hefti M, Holenstein F, Albert I, Looser H, Luginbuehl V (2011) Sesceptibility to 5-aminolevulinic acid based photodynamic therapy in WHO I meningioma cells corresponds to ferrochelatase activity. Photochem Photobiol 87:235–241
Ohgari Y, Nakayasu Y, Kitajima S, Sawamoto M, Mori H, Shimokawa O, Matsui H, Taketani S (2005) Mechanisms involved in delta-aminolevulinic acid (ALA)-induced photosensitivity of tumor cells: relation of ferrochelatase and uptake of ALA to the accumulation of protoporphyrin. Biochem Pharmacol 71:42–49
Stout DL, Becker FF (1990) Heme synthesis in normal mouse liver and mouse liver tumors. Cancer Res 50:2337–2340
Navone NM, Polo CF, Frisardi AL, Andrade NE, Battle AM (1990) Heme biosynthesis in human breast cancer-mimetic “in vitro” studies and some heme enzymic activity levels. Int J Biochem 22:1407–1411
Wachowska M, Muchowicz A, Firczuk M, Gabrysiak M, Winiarska M, Wańczyk M, Bojarczuk K, Golab J (2011) Aminolevulinic acid (ALA) as a prodrug in photodynamic therapy of cancer. Molecules 16:4140–4164
Collaud S, Juzenziene A, Lange N (2004) On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation. Curr Med Chem Anticancer Agents 4:301–316
http://www.dermotopics.de/german/ausgabe1_09_d/DIP1_09_d.htm
Grüning N, Müller-Goymann CC (2008) Physicochemical characterisation of a novel thermogelling formulation for percutaneous penetration of 5-aminolevulinic acid. J Pharm Sci 97:2311–2323
Forster B, Klein A, Szeimies RM, Maisch T (2010) Penetration enhancement of two topical 5-aminolaevulinic acid formulations for photodynamic therapy by erbium: YAG laser ablation of the stratum corneum: continuous versus fractional ablation. Exp Dermatol 19:806–812
Mikolajewska P, Donnelly RF, Garland MJ, Morrow DI, Singh TR, Iani V, Moan J, Juzeniene A (2010) Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema. Pharm Res 27:2213–2220
Lopez RF, Bentley MV, Delgado-Charro MB, Salomon D, van den Bergh H, Lange N, Guy RH (2003) Enhanced delivery of 5-aminolevulinic acid esters by iontophoresis in vitro. Photochem Photobiol 77:304–308
Johansson A, Svensson J, Bendsoe N, Svanberg K, Alexandratou E, Kyriazi M, Yova D, Gräfe S, Trebst T, Andersson-Engels S (2007) Fluorescence and absorption assessment of a lipid mTHPC formulation following topical application in a non-melanotic skin tumor model. J Biomed Opt 12:034026
Alexandratou E., Kyriazi M, Trebst T, Gräfe S, Yova D (2007) Photodynamic therapy of non melanoma skin cancer murine model by topical application of a novel mTHPC liposomal formulation. In: Proceedings SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 66320 V, 03 July 2007
Scheglmann D, Fahr A, Gräfe S, Neuberger W, Albrecht V (2011) Temoporfin and its liposomal formulations Foslip and Fospeg—Properties and behavior. Photodiagnosis and Photodynamic Therapy 8(2):195
Boehm TK, Ciancio SG (2011) Diode laser activated indocyanine green selectively kills bacteria. J Int Acad Periodontol 3(2):58–63
Tuchin VV, Genina EA, Bashkatov AN, Simonenko GV, Odoevskaya OD, Altshuler GB (2003) A pilot study of ICG laser therapy of acne vulgaris: photodynamic and photothermolysis treatment. Lasers Surg Med 33(5):296–310
König K, Schneckenburger H, Rück A, Steiner R (1993) In vivo photoproduct formation during PDT with ALA-induced endogenous porphyrins. J Photochem Photobiol, B 18(2–3):287–290
Dysart JS, Patterson MS (2006) Photobleaching kinetics, photoproduct formation, and dose estimation during ALA induced PpIX PDT of MLL cells under well oxygenated and hypoxic conditions. Photochem Photobiol Sci 5(1):73–81
König K, Wyss-Desserich MT, Tadir Y, Haller U, Tromberg B, Berns MW, Wyss P (2006) Modifications of protoporphyrin IX fluorescence during ALA-based photodynamic therapy of endometriosis. Med Laser Appl 21(4):291–297
Theodossiou T, MacRobert AJ (2002) Comparison of the photodynamic effect of exogenous photoprotoporphyrin and protoporphyrin IX on PAM 212 murine keratinocytes. Photochem Photobiol 76(5):530–537
Department of Biology, Davidson College, Davidson, NC 28035. Fluorescence recovery after photobleaching (FRAP). <http://www.bio.davidson.edu/Courses/Molbio/FRAPx/FRAP.html>
Moan J, Ma L, Iani V, Juzeniene A (2005) Influence of light exposure on the kinetics of protoporphyrin IX formation in normal skin of hairless mice after application of 5-aminolevulinic acid methyl ester. J Invest Dermatol 125(5):1039–1044
Orenstein A, Kostenich G, Malik Z (1997) The kinetics of protoporphyrin fluorescence during ALA-PDT in human malignant skin tumors. Cancer Lett 120(2):229–234
Van der Veen N, De Bruijn HS, Star WM (1997) Photobleaching during and re-appearance after photodynamic therapy of topical ALA-induced fluorescence in UVB-treated mouse skin. Int J Cancer 72(1):110–118
Dietel W, Pottier R, Pfister W, Schleier P, Zinner K (2007) 5-Aminolaevulinic acid (ALA) induced formation of different fluorescent porphyrins: a study of the biosynthesis of porphyrins by bacteria of the human digestive tract. J Photochem Photobiol, B 86(1):77–86
Attili SK, Lesar A, McNeill A, Camacho-Lopez M, Moseley H, Ibbotson S, Samuel ID, Ferguson J (2009) An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer. Br J Dermatol 161(1):170–173
Brancaleon L, Moseley H (2002) Laser and non-laser light sources for photodynamic therapy. Lasers Med Sci 17(3):173–186
Wiegell SR, Haedersdal M, Philipsen PA, Eriksen P, Enk CD, Wulf HC (2008) Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded study. Br J Dermatol 158:740–746
Wiegell SR, Hædersdal M, Eriksen P, Wulf HC (2009) Photodynamic therapy of actinic keratoses with 8% and 16% methyl aminolaevulinate and home-based daylight exposure: a double-blinded randomized clinical trial. Br J Dermatol 160:1308–1314
Fayter D, Corbett M, Heirs M, Fox D, Eastwood A (2010) A systematic review of photodynamic therapy in the treatment of pre-cancerous skin conditions. Barrett’s oesophagus and cancers of the biliary tract, brain, head and neck, lung, oesophagus and skin. Health Technol Assess 14:37
Kaufmann R, Spelman L, Weightman W, Reifenberger J, Szeimies RM, Verhaeghe E et al (2008) Multicentre intraindividual randomized trial of topical methyl aminolaevulinate-photodynamic therapy vs. cryotherapy for multiple actinic keratoses on the extremities. Br J Dermatol 158:994–999
Szeimies RM, Karrer S, Radakovic-Fijan S, Tanew A, Calzavara-Pinton PG, Zane C et al (2002) Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study. J Am Acad Dermatol 47:258–262
Morton C, Campbell S, Gupta G, Keohane S, Lear J, Zaki I et al (2006) Intraindividual, right-left comparison of topical methyl aminolaevulinate-photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicentre, randomized controlled study. Br J Dermatol 155:1029–1036
Freeman M, Vinciullo C, Francis D, Spelman L, Nguyen R, Fergin P et al (2003) A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study. J Dermatol Treat 14:99–106
Sotiriou E, Apalla Z, Maliamani F, Zaparas N, Panagiotidou D, Ioannides D (2009) Intraindividual, rightleft comparison of topical 5-aminolevulinic acidphotodynamic therapy vs. 5% imiquimod creamfor actinic keratoses on the upper extremities. J EurAcad Dermatol Venereol 23:1061–1065
Dragieva G, Prinz BM, Hafner J, Dummer R, Burg G, Binswanger U et al (2004) A randomized controlled clinical trial of topical photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratoses in transplant recipients. Br J Dermatol 151:196–200
Cox NH, Eedy DJ, Morton CA (1999) Guidelines for management of Bowen’s disease. British association of dermatologists. Br J Dermatol 141:633–641
Morton C, Horn M, Leman J, Tack B, Bedane C, Tjioe M et al (2006) Comparison of topical methyl aminolevulinate photodynamic therapy with cryotherapy or Fluorouracil for treatment of squamous cell carcinoma in situ: results of a multicenter randomized trial. Arch Dermatol 142:729–735
van der Snoek EM, den Hollander JC, Aans JB, Sterenborg HJ, van der Ende ME, Robinson DJ (2012) Photodynamic therapy with systemic meta-tetrahydroxyphenylchlorin in the treatment of anal intraepithelial neoplasia, grade 3. Lasers Surg Med 44(8):637–44
Szeimies RM, Ibbotson S, Murrell DF, Rubel D, Frambach Y, de Berker D et al (2008) A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8–20 mm), with a 12-month follow-up. J Eur Acad Dermatol Venereol 22:1302–1311
Rhodes LE, de Rie MA, Leifsdottir R, Yu RC, Bachmann I, Goulden V et al (2007) Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma. Arch Dermatol 143:1131–1136
Berroeta L, Clark C, Dawe RS, Ibbotson SH, Fleming CJ (2007) A randomized study of minimal curettage followed by topical photodynamic therapy compared with surgical excision for low-risk nodular basal cell carcinoma. Br J Dermatol 157:401–403
Betz CS, Rauschning W, Stranadko EP, Riabov MV, Volgin VN, Albrecht V, Nifantiev NE, Hopper C (2012) Long-term outcomes following Foscan®-PDT of basal cell carcinomas. Lasers Surg Med 44(7):533–540
Edstrom DW, Hedblad MA (2008) Long-term follow-up of photodynamic therapy for mycosis fungoides. Acta Derm Venereol 88(3):288–290
Debu A, Bessis D, Girard C, Du Thanh A, Guillot B, Dereur O (2013) Photodynamic therapy with methyl aminolaevulinate for cervical and/or facial lesions of folliculotropic mycosis fungoides: interest and limits. Br J Dermatol 168(4):896–898
Kennedy JC, Pottier RH, Pross DC (1990) Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol, B 6:143–148
Fabbrocini G, De Vita V, Monfrecola A (2010) Photodynamic therapy with 20% topical 5-Aminolaevulinic Acid or Placebo for the treatment of common therapies-resistant plantar warts: a randomised double-blind trial. J Egypt Women Dermatol Soc 7(2):81–86
Szeimies RM, Schleyer V, Moll I, Stocker M, Landthaler M, Karrer S (2009) Adjuvant photodynamic therapy does not prevent recurrence of condylomata acuminata after carbon dioxide laser ablation—A phase III, prospective, randomized, bicentric, double-blind study. Dermatol Surg 35(5):757–764
Itoh Y, Ninomiya Y, Tajima S et al (2001) Photodynamic therapy of acne vulgaris with topical delta-aminolaevulinic acid and incoherent light in Japanese patients. Br J Dermatol 144:575–579
Kohl EA, Karrer S (2012) Photodynamic skin rejuvenation. Photonics and Lasers in Medicine 1:27–33
Gardlo K, Horska Z, Enk CD, Rauch L, Megahed M, Ruzicka T, Fritsch C (2003) Treatment of cutaneous leishmaniasis by photodynamic therapy. J Am Acad Dermatol 48(6):893–896
Akilov OE, Kosaka S, O’Riordan K, Hasan T (2007) Parasiticidal effect of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells. Exp Dermatol 16(8):651–660
Welzel J, Lankenau E, Birngruber R, Engelhardt R (1997) Optical coherence tomography of the human skin. J Am Acad Dermatol 37(6):958–963
Steiner R, Kunzi-Rapp K, Scharffetter-Kochanek K (2003) Optical coherence tomography: clinical applications in dermatology. Med Laser Appl 18(3):249–259
Gambichler T, Orlikov A, Vasa R, Moussa G, Hoffmann K, Stücker M, Altmeyer P, Bechara FG (2007) In vivo optical coherence tomography of basal cell carcinoma. J Dermatol Sci 45(3):167–173
Mogensen M, Morsy HA, Thrane L, Jemec GB (2008) Morphology and epidermal thickness of normal skin imaged by optical coherence tomography. Dermatology 217(1):14–20
Mogensen M, Nürnberg BM, Forman JL, Thomsen JB, Thrane L, Jemec GB (2009) In vivo thickness measurement of basal cell carcinoma and actinic keratosis with optical coherence tomography and 20-MHz ultrasound. Br J Dermatol 160(5):1026–1033
Jenkins FA, White HE (1957) Fundamentals of optics. McGraw-Hill, New York
Ziolkowska M, Philipp CM, Liebscher J, Berlien H-P (2009) OCT of healthy skin, actinic skin and NMSC lesions. Med Laser Appl 24(4):256–264
Mogensen M, Joergensen TM, Nürnberg BM, Morsy HA, Thomsen JB, Thrane L et al (2009) Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg 35(6):965–972
Göppner D, Mechow N, Liebscher J, Thiel E, Seewald G, Buchholz A, Gollnick H, Philipp CM, Schönborn K-H (2012) High-resolution two-photon imaging of HE-stained samples in dermatohistopathology—A pilot study on skin tumours. Photonics Lasers Med 1(2):133–140
Acknowledgments
I would like to thank all my coworkers in clinical and experimental PDT in our clinic and in particular to Maria Ziolkowska, Friederike Hirsch and Max Klomsdorff who prepared the grafics and OCT-images for this article.
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Philipp, C.M. (2014). PDT in Dermatology. In: Abdel-Kader, M. (eds) Photodynamic Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39629-8_7
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