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Molecular Genetics of Rare Lymphomas

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Rare Lymphomas

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

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Abstract

Non-Hodgkin’s lymphoma represents a heterogeneous group of malignancies with diverse clinical manifestations, histologic characteristics, and biologic behavior. Recent improvements in pathologic diagnosis as well as the application of novel molecular biological techniques in clinical routine have led to the distinction of various subtypes of malignant lymphoma that occur at rather low frequencies. These lymphoma subtypes are here referred to as “rare lymphomas”.

A correct pathologic diagnosis of these uncommon entities is a prerequisite for adequate treatment strategies especially as a significant number of these “rare lymphoma” subtypes are characterized by adverse survival. Therefore, a better understanding of the biology of these entities is critically warranted to substantially improve prognosis. This chapter summarizes current concepts of our understanding of the molecular pathogenesis of “rare lymphomas” subtypes. This is exemplified by focusing on selected subtypes, namely, primary mediastinal B-cell lymphoma, Burkitt lymphoma, and mantle cell lymphoma.

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Authors and Affiliations

  1. Department of Hematology, Oncology and Tumor Immunology, Molecular Cancer Research Center, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Sören-Sebastian Wenzel & Georg Lenz MD

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  1. Sören-Sebastian Wenzel
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  2. Georg Lenz MD
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Correspondence to Georg Lenz MD .

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Editors and Affiliations

  1. Medizinischen Klinik und Poliklinik III, Universität München Klinikum Großhadern, München, Germany

    Martin Dreyling

  2. Division of Hematology/Oncology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia, USA

    Michael E. Williams

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Wenzel, SS., Lenz, G. (2014). Molecular Genetics of Rare Lymphomas. In: Dreyling, M., Williams, M. (eds) Rare Lymphomas. Hematologic Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39590-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-39590-1_3

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