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Principles of the Pathology and Biology of Malignant Lymphomas

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Rare Lymphomas

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

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Abstract

The lymphoma classification currently in use, the fourth edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (Swerdlow SH et al, (eds) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. IARC, Lyon, 2008), is founded on the basic principles of the Revised European American Lymphoma (REAL) Classification of 1994 (Harris NL et al, A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361–1392, 1994). These principles, however, had been recognized earlier. Divergent and conflicting proposals for lymphoma classifications had been formulated in the 1970s, resulting in the emergence of two classification systems widely used: the Kiel classification of non-Hodgkin’s lymphomas (Stansfeld, et al, Updated Kiel classification for lymphomas. Lancet I: 292–293, 603, 1988) and the working formulation for clinical usage (WF; Non-Hodgkin’s lymphoma pathologic classification project 1982). Both classification systems relied upon entirely different principles. The Kiel classification was based on the exact morphological description and (later) immunological identification of the normal cellular counterparts of tumor cells and was updated several times.

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Acknowledgement

The expert technical assistance of Mrs. Elisabeth Ott is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany

    German Ott MD

  2. Department of Clinical Pathology, Cleveland Clinic, L11, 9500 Euclid Ave, Cleveland, OH, 44195, USA

    Eric D. Hsi MD

  3. Department of Pathology, Oslo University Hospital, Oslo, Norway

    Jan Delabie MD

  4. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Scott Rodig MD

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  1. German Ott MD
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  2. Eric D. Hsi MD
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Correspondence to German Ott MD .

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Editors and Affiliations

  1. Medizinischen Klinik und Poliklinik III, Universität München Klinikum Großhadern, München, Germany

    Martin Dreyling

  2. Division of Hematology/Oncology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia, USA

    Michael E. Williams

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Ott, G., Hsi, E.D., Delabie, J., Rodig, S. (2014). Principles of the Pathology and Biology of Malignant Lymphomas. In: Dreyling, M., Williams, M. (eds) Rare Lymphomas. Hematologic Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39590-1_1

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  • DOI: https://doi.org/10.1007/978-3-642-39590-1_1

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