A Role for Epigenetic Modulation of the Innate Immune Response During Aging
- 1.9k Downloads
The ageing process results from a complex interplay between genes and the environment that can precipitate an uncontrolled inflammation. Epigenetic changes are believed to provide a link between the environment and nutrition to gene expression by altering the activity of some histone-modifying protein. Epigenetic modifications of DNA and histone proteins have been proposed as important contributory mechanisms to the retention of metabolic memory over time. A thorough understanding of the posttranscriptional and epigenetic factors involved in both normal ageing and age-related disease may inform new strategies and approaches to diagnose, treat, or suppress many aspects of age-dependent frailty.
KeywordsHistone Acetylation Histone Methylation Histone Protein Histone Acetyl Transferase Innate Immune Signaling
Funding is gratefully acknowledged from the following sources BBSRC (JWK); BBSRC (SJB); Alzheimer’s Research UK (IHKD); FP7 MARK-AGE (EU FP7 Large-scale integrating Project HEALTH-F4-2008-2008800 (CRD); COST CM1001 and BM1203 (HRG).
- Koch CM, Wagner W (2011) Epigenetic-aging-signature to determine age in different tissues. Aging (Albany NY) 3(10):1018–1027Google Scholar
- Medawar PB (1952) An unsolved problem in biology. Lewis, London. Reprinted in Medawar PG (1981) The uniqueness of the individual. Dover, New YorkGoogle Scholar
- Pearl R (1928) The rate of living. University of London Press, LondonGoogle Scholar