Aging Immunity and the Impact of Physical Exercise

  • Guillaume Spielmann
  • Austin B. Bigley
  • Emily C. LaVoy
  • Richard J. SimpsonEmail author


Regular physical exercise is associated with increased longevity and a lower risk of developing several age-associated diseases. In addition, regular exercise has been purported as a simple lifestyle intervention to counteract the deleterious effects of age-associated changes in immunity known as immunosenescence. Etiology of immunosenescence is multifaceted and can impact on both arms of the immune system. Since 1990, several longitudinal ageing studies using aerobic- and/or resistance-based exercise provided growing information on the benefits of exercise in both innate immunity and adaptive immunity. Regular exercise can improve responses to vaccines, NK-cell function, neutrophil phagocytic activity, and T-cell proliferation. It also reduces circulatory inflammatory mediators and inflammatory response to bacterial challenge. These findings provide a strong indication that habitual exercise has immune regulatory properties and may help delay the onset of immunosenescence.


Natural Killer Cell Exercise Training Resistance Training CD56bright Natural Killer Cell Exercise Training Intervention 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Guillaume Spielmann
    • 1
  • Austin B. Bigley
    • 1
  • Emily C. LaVoy
    • 1
  • Richard J. Simpson
    • 1
    Email author
  1. 1.Laboratory of Integrated Physiology, Department of Health and Human PerformanceUniversity of HoustonHoustonUSA

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