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Diet and Immunosenescence

  • Giulia Accardi
  • Carmela Rita BalistreriEmail author
  • Calogero Caruso
  • Giuseppina Candore
Chapter

Abstract

Ageing is a systemic condition leading to a gradual loss of molecular and cellular fidelity. A feature of ageing is immunosenescence, consisting in several modifications that increase morbidity and mortality in elderly. Environment, genetic background, immune system, and intestinal microbiota play a fundamental role in immunosenescence. The development of a chronic, low-grade, inflammatory status, known as “inflamm-ageing,” is a typical aspect of immunosenescence mostly due to the pro-inflammatory cytokine production linked to the chronic antigenic load. Nutrition can act on ageing, immunity, and health in general. Unbalanced diet with an insufficient intake of micro- and macronutrient and vitamins is a major nutritional problem among elderly, resulting in a dramatic change in gut microbiota. Calorie restriction and long-term adherence to Mediterranean diet could prevent or manage age-related diseases and immunosenescence.

Keywords

Calorie Restriction Mediterranean Diet Intestinal Microbiota Zinc Supplementation Zinc Intake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Giulia Accardi
    • 1
  • Carmela Rita Balistreri
    • 1
    Email author
  • Calogero Caruso
    • 1
  • Giuseppina Candore
    • 1
  1. 1.Department of Pathobiology and Medical and Forensic BiotechnologiesUniversity of Palermo90134Italy

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