Nutrition, Immunity, and Aging

  • Armin Hirbod-Mobarakeh
  • Maryam MahmoudiEmail author
  • Nima Rezaei


The extent of immunosenescence varies among individuals depending on several factors, including genetics, environment, lifestyle, and nutrition. The concept of nutrition as a modifiable factor with widespread influence on the immune system has established the foundation of the immunonutrition. Immunosenescence can be classified into three categories in regard to nutritional status including primary immunosenescence, secondary immunosenescence, and tertiary immunosenescence. Nutritional status, itself, depends on several factors in the elderly, and three main categories of physical, psychological, and social factors are responsible for susceptibility of the elderly to undernutrition. All these factors should be assessed in order to accurately evaluate nutritional status which is essential for successful immunonutrition in the elderly. This chapter will review the effect of nutritional status on immunosenescence in the elderly along with thorough assessment of nutritional status and contributory factors to undernutrition in the elderly. Also we will review immunonutrition options as one of the cost-effective approaches to delay immunosenescence.


Anorexia Nervosa Caloric Restriction Zinc Deficiency Humoral Immunity Respiratory Burst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Armin Hirbod-Mobarakeh
    • 1
  • Maryam Mahmoudi
    • 2
    Email author
  • Nima Rezaei
    • 1
    • 3
    • 4
  1. 1.Molecular Immunology Research CenterTehran University of Medical SciencesTehranIran
  2. 2.School of Nutrition and DieteticsTehran University of Medical SciencesTehranIran
  3. 3.Research Center for Immunodeficiencies, Children’s Medical CenterTehranIran
  4. 4.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran

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