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Nutrition, Immunity, and Aging

  • Armin Hirbod-Mobarakeh
  • Maryam MahmoudiEmail author
  • Nima Rezaei
Chapter

Abstract

The extent of immunosenescence varies among individuals depending on several factors, including genetics, environment, lifestyle, and nutrition. The concept of nutrition as a modifiable factor with widespread influence on the immune system has established the foundation of the immunonutrition. Immunosenescence can be classified into three categories in regard to nutritional status including primary immunosenescence, secondary immunosenescence, and tertiary immunosenescence. Nutritional status, itself, depends on several factors in the elderly, and three main categories of physical, psychological, and social factors are responsible for susceptibility of the elderly to undernutrition. All these factors should be assessed in order to accurately evaluate nutritional status which is essential for successful immunonutrition in the elderly. This chapter will review the effect of nutritional status on immunosenescence in the elderly along with thorough assessment of nutritional status and contributory factors to undernutrition in the elderly. Also we will review immunonutrition options as one of the cost-effective approaches to delay immunosenescence.

Keywords

Anorexia Nervosa Caloric Restriction Zinc Deficiency Humoral Immunity Respiratory Burst 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Adolfsson O, Huber BT, Meydani SN (2001) Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity. J Immunol 167(7):3809–3817PubMedGoogle Scholar
  2. Ahmed T, Haboubi N (2010) Assessment and management of nutrition in older people and its importance to health. Clin Interv Aging 5:207–216PubMedGoogle Scholar
  3. Ahmed T, Das SK, Golden JK et al (2009) Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women. J Gerontol A Biol Sci Med Sci 64(11):1107–1113PubMedCrossRefGoogle Scholar
  4. Arthur JR, McKenzie RC, Beckett GJ (2003) Selenium in the immune system. J Nutr 133(5 Suppl 1):1457S–1459SPubMedGoogle Scholar
  5. Aukrust P, Muller F, Ueland T et al (2000) Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses. Eur J Clin Invest 30(3):252–259PubMedCrossRefGoogle Scholar
  6. Baba N, Samson S, Bourdet-Sicard R et al (2009) Selected commensal-related bacteria and Toll-like receptor 3 agonist combinatorial codes synergistically induce interleukin-12 production by dendritic cells to trigger a T helper type 1 polarizing programme. Immunology 128(1 Suppl):e523–e531PubMedCrossRefGoogle Scholar
  7. Barbul A (2000) Immunonutrition comes of age. Crit Care Med 28(3):884–885PubMedCrossRefGoogle Scholar
  8. Bates B, Bickley LS, Szilagyi PG (2009) Bates’ guide to physical examination and history taking. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  9. Bengmark S (2006) Impact of nutrition on ageing and disease. Curr Opin Clin Nutr Metab Care 9(1):2–7PubMedCrossRefGoogle Scholar
  10. Bitar KN, Patil SB (2004) Aging and gastrointestinal smooth muscle. Mech Ageing Dev 125(12):907–910PubMedCrossRefGoogle Scholar
  11. Bitar K, Greenwood-Van Meerveld B, Saad R et al (2011) Aging and gastrointestinal neuromuscular function: insights from within and outside the gut. Neurogastroenterol Motil 23(6):490–501PubMedCrossRefGoogle Scholar
  12. BM L (ed) (2001) Handbook of Nutrition and the Aged. CRC Press, New YorkGoogle Scholar
  13. Bogden JD, Louria DB (1999) Aging and the immune system: the role of micronutrient nutrition. Nutrition 15(7–8):593–595PubMedCrossRefGoogle Scholar
  14. Bonham M, O’Connor JM, Hannigan BM et al (2002) The immune system as a physiological indicator of marginal copper status? Br J Nutr 87(5):393–403PubMedCrossRefGoogle Scholar
  15. Brownie S (2006) Why are elderly individuals at risk of nutritional deficiency? Int J Nurs Pract 12(2):110–118PubMedCrossRefGoogle Scholar
  16. Burk RF (2002) Selenium, an antioxidant nutrient. Nutr Clin Care 5(2):75–79PubMedCrossRefGoogle Scholar
  17. Bush LA, Horenkamp N, Morley JE et al (1996) D-E-N-T-A-L: a rapid self-administered screening instrument to promote referrals for further evaluation in older adults. J Am Geriatr Soc 44(8):979–981PubMedGoogle Scholar
  18. Calder PC (2007) Immunonutrition in surgical and critically ill patients. Br J Nutr 98(Suppl 1):S133–S139PubMedGoogle Scholar
  19. Calder PC, Kew S (2002) The immune system: a target for functional foods? Br J Nutr 88(Suppl 2):S165–S177PubMedCrossRefGoogle Scholar
  20. Cantorna MT, Nashold FE, Hayes CE (1994) In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. J Immunol 152(4):1515–1522PubMedGoogle Scholar
  21. Cantorna MT, Zhu Y, Froicu M et al (2004) Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 80(6 Suppl):1717S–1720SPubMedGoogle Scholar
  22. Castle SC (2000) Clinical relevance of age-related immune dysfunction. Clin Infect Dis 31(2):578–585PubMedCrossRefGoogle Scholar
  23. Cederholm T, Morley J (2013) Ageing: biology and nutrition. Curr Opin Clin Nutr Metab Care 16(1):1–2PubMedCrossRefGoogle Scholar
  24. Chandra RK (1983) Nutrition, immunity, and infection: present knowledge and future directions. Lancet 1(8326 Pt 1):688–691PubMedGoogle Scholar
  25. Chandra RK (1997) Nutrition and the immune system: an introduction. Am J Clin Nutr 66(2):460S–463SPubMedGoogle Scholar
  26. Chandra RK (2002) Nutrition and the immune system from birth to old age. Eur J Clin Nutr 56(Suppl 3):S73–S76PubMedCrossRefGoogle Scholar
  27. Chandra RK, Sudhakaran L (1990) Regulation of immune responses by vitamin B6. Ann N Y Acad Sci 585:404–423PubMedCrossRefGoogle Scholar
  28. Chapman IM, MacIntosh CG, Morley JE et al (2002) The anorexia of ageing. Biogerontology 3(1–2):67–71PubMedCrossRefGoogle Scholar
  29. Chen CC, Schilling LS, Lyder CH (2001) A concept analysis of malnutrition in the elderly. J Adv Nurs 36(1):131–142PubMedCrossRefGoogle Scholar
  30. Clarke DM, Wahlqvist ML, Strauss BJ (1998) Undereating and undernutrition in old age: integrating bio-psychosocial aspects. Age Ageing 27(4):527–534PubMedCrossRefGoogle Scholar
  31. Courtemanche C, Elson-Schwab I, Mashiyama ST et al (2004) Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol 173(5):3186–3192PubMedGoogle Scholar
  32. Courtney ME, Greene HL, Folk CC et al (1982) Rapidly declining serum albumin values in newly hospitalized patients: prevalence, severity, and contributory factors. JPEN J Parenter Enteral Nutr 6(2):143–145PubMedCrossRefGoogle Scholar
  33. Cunningham-Rundles S, McNeeley DF, Moon A (2005) Mechanisms of nutrient modulation of the immune response. J Allergy Clin Immunol 115(6):1119–1128; quiz 1129PubMedCrossRefGoogle Scholar
  34. Darnton-Hill I (1992) Psychosocial aspects of nutrition and aging. Nutr Rev 50(12):476–479PubMedCrossRefGoogle Scholar
  35. de Moreno de LeBlanc A, Chaves S, Carmuega E et al (2008) Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophages. Immunobiology 213(2):97–108PubMedCrossRefGoogle Scholar
  36. Delcenserie V, Martel D, Lamoureux M et al (2008) Immunomodulatory effects of probiotics in the intestinal tract. Curr Issues Mol Biol 10(1–2):37–54PubMedGoogle Scholar
  37. Delpeuch F, Cornu A, Chevalier P (1980) The effect of iron-deficiency anaemia on two indices of nutritional status, prealbumin and transferrin. Br J Nutr 43(2):375–379PubMedCrossRefGoogle Scholar
  38. Deluca HF, Cantorna MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15(14):2579–2585PubMedCrossRefGoogle Scholar
  39. Dhur A, Galan P, Hercberg S (1991) Folate status and the immune system. Prog Food Nutr Sci 15(1–2):43–60PubMedGoogle Scholar
  40. Elmadfa I, Klein P, Meyer AL (2010) Immune-stimulating effects of lactic acid bacteria in vivo and in vitro. Proc Nutr Soc 69(3):416–420PubMedCrossRefGoogle Scholar
  41. Elsner RJ (2002) Changes in eating behavior during the aging process. Eat Behav 3(1):15–43PubMedCrossRefGoogle Scholar
  42. Ewing JA (1984) Detecting alcoholism. The CAGE questionnaire. JAMA 252(14):1905–1907PubMedCrossRefGoogle Scholar
  43. Fernandes G (2008) Progress in nutritional immunology. Immunol Res 40(3):244–261PubMedCrossRefGoogle Scholar
  44. Fich A, Camilleri M, Phillips SF (1989) Effect of age on human gastric and small bowel motility. J Clin Gastroenterol 11(4):416–420PubMedCrossRefGoogle Scholar
  45. Field CJ, Johnson IR, Schley PD (2002) Nutrients and their role in host resistance to infection. J Leukoc Biol 71(1):16–32PubMedGoogle Scholar
  46. Finkelstein JA, Schiffman SS (1999) Workshop on taste and smell in the elderly: an overview. Physiol Behav 66(2):173–176PubMedCrossRefGoogle Scholar
  47. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198PubMedCrossRefGoogle Scholar
  48. Galli C, Calder PC (2009) Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review. Ann Nutr Metab 55(1–3):123–139PubMedCrossRefGoogle Scholar
  49. Goldberg DM, Brown D (1987) Advances in the application of biochemical tests to diseases of the liver and biliary tract: their role in diagnosis, prognosis, and the elucidation of pathogenetic mechanisms. Clin Biochem 20(2):127–148PubMedCrossRefGoogle Scholar
  50. Griffin MD, Xing N, Kumar R (2003) Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr 23:117–145PubMedCrossRefGoogle Scholar
  51. Grimble RF (2005) Immunonutrition. Curr Opin Gastroenterol 21(2):216–222PubMedCrossRefGoogle Scholar
  52. Grimm H, Calder PC (2002) Immunonutrition. Br J Nutr 87(Suppl 1):S1PubMedCrossRefGoogle Scholar
  53. Guarner F, Schaafsma GJ (1998) Probiotics. Int J Food Microbiol 39(3):237–238PubMedCrossRefGoogle Scholar
  54. Halevy O, Arazi Y, Melamed D et al (1994) Retinoic acid receptor-alpha gene expression is modulated by dietary vitamin A and by retinoic acid in chicken T lymphocytes. J Nutr 124(11):2139–2146PubMedGoogle Scholar
  55. Hartel C, Strunk T, Bucsky P et al (2004) Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Cytokine 27(4–5):101–106PubMedCrossRefGoogle Scholar
  56. Hayes CE, Nashold FE, Spach KM et al (2003) The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand) 49(2):277–300Google Scholar
  57. Hays NP, Roberts SB (2006) The anorexia of aging in humans. Physiol Behav 88(3):257–266PubMedCrossRefGoogle Scholar
  58. Henry M, Seidel M, Jane W et al (2011) Mosby’s guide to physical examination, 7th edn. Elsevier, PhiladelphiaGoogle Scholar
  59. High KP (2001) Nutritional strategies to boost immunity and prevent infection in elderly individuals. Clin Infect Dis 33(11):1892–1900PubMedCrossRefGoogle Scholar
  60. Ibs KH, Rink L (2003) Zinc-altered immune function. J Nutr 133(5 Suppl 1):1452S–1456SPubMedGoogle Scholar
  61. Iyer SS, Chatraw JH, Tan WG et al (2012) Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells. J Immunol 188(1):77–84PubMedCrossRefGoogle Scholar
  62. Jacob RA, Kelley DS, Pianalto FS et al (1991) Immunocompetence and oxidant defense during ascorbate depletion of healthy men. Am J Clin Nutr 54(6 Suppl):1302S–1309SPubMedGoogle Scholar
  63. Kim W, Khan NA, McMurray DN et al (2010) Regulatory activity of polyunsaturated fatty acids in T-cell signaling. Prog Lipid Res 49(3):250–261PubMedCrossRefGoogle Scholar
  64. Koretz RL (2003) Immunonutrition: can you be what you eat? Curr Opin Gastroenterol 19(2):134–139PubMedCrossRefGoogle Scholar
  65. Lane MA, Black A, Handy A et al (2001) Caloric restriction in primates. Ann N Y Acad Sci 928:287–295PubMedCrossRefGoogle Scholar
  66. Laugier R, Bernard JP, Berthezene P et al (1991) Changes in pancreatic exocrine secretion with age: pancreatic exocrine secretion does decrease in the elderly. Digestion 50(3–4):202–211PubMedCrossRefGoogle Scholar
  67. Lesourd BM (1997) Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am J Clin Nutr 66(2):478S–484SPubMedGoogle Scholar
  68. Lesourd B (2004) Nutrition: a major factor influencing immunity in the elderly. J Nutr Health Aging 8(1):28–37PubMedGoogle Scholar
  69. Lesourd B (2006) Nutritional factors and immunological ageing. Proc Nutr Soc 65(3):319–325PubMedCrossRefGoogle Scholar
  70. Lesourd B, Mazari L (1999) Nutrition and immunity in the elderly. Proc Nutr Soc 58(3):685–695PubMedCrossRefGoogle Scholar
  71. Lesourd BM, Mazari L, Ferry M (1998) The role of nutrition in immunity in the aged. Nutr Rev 56(1 Pt 2):S113–S125PubMedGoogle Scholar
  72. Ligthart GJ, Corberand JX, Fournier C et al (1984) Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev 28(1):47–55PubMedCrossRefGoogle Scholar
  73. Lipschitz DA, Udupa KB (1986) Influence of aging and protein deficiency on neutrophil function. J Gerontol 41(6):690–694PubMedCrossRefGoogle Scholar
  74. Lotfy OA, Saleh WA, el-Barbari M (1998) A study of some changes of cell-mediated immunity in protein energy malnutrition. J Egypt Soc Parasitol 28(2):413–428PubMedGoogle Scholar
  75. Maggini S, Wintergerst ES, Beveridge S et al (2007) Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr 98(Suppl 1):S29–S35PubMedGoogle Scholar
  76. Marcos A, Nova E, Montero A (2003) Changes in the immune system are conditioned by nutrition. Eur J Clin Nutr 57(Suppl 1):S66–S69PubMedCrossRefGoogle Scholar
  77. Marik PE, Zaloga GP (2008) Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med 34(11):1980–1990PubMedCrossRefGoogle Scholar
  78. Martin CT, Kayser-Jones J, Stotts NA et al (2007) Risk for low weight in community-dwelling, older adults. Clin Nurse Spec 21(4):203–211; quiz 212–203PubMedCrossRefGoogle Scholar
  79. Messaoudi I, Warner J, Fischer M et al (2006) Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A 103(51):19448–19453PubMedCrossRefGoogle Scholar
  80. Messaoudi I, Fischer M, Warner J et al (2008) Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. Aging Cell 7(6):908–919PubMedCrossRefGoogle Scholar
  81. Meydani M (2001) Nutrition interventions in aging and age-associated disease. Ann N Y Acad Sci 928:226–235PubMedCrossRefGoogle Scholar
  82. Meydani SN, Han SN, Wu D (2005) Vitamin E and immune response in the aged: molecular mechanisms and clinical implications. Immunol Rev 205:269–284PubMedCrossRefGoogle Scholar
  83. Miller DK, Morley JE, Rubenstein LZ et al (1991) Abnormal eating attitudes and body image in older undernourished individuals. J Am Geriatr Soc 39(5):462–466PubMedGoogle Scholar
  84. Nutritional Care Consensus Group (1995) Measurement of visceral protein status in assessing protein and energy malnutrition: standard of care. Nutrition 11(2):169–171Google Scholar
  85. Office of National Statistics (2011) Population trends. Population and Demography Division. http://www.ons.gov.uk/ons/rel/population-trends-rd/population-trends/no--145--autumn-2011/index.html. Accessed 1 Jan 2013
  86. Omran ML, Morley JE (2000a) Assessment of protein energy malnutrition in older persons, part I: History, examination, body composition, and screening tools. Nutrition 16(1):50–63PubMedCrossRefGoogle Scholar
  87. Omran ML, Morley JE (2000b) Assessment of protein energy malnutrition in older persons, Part II: laboratory evaluation. Nutrition 16(2):131–140PubMedCrossRefGoogle Scholar
  88. Oppenheimer SJ (2001) Iron and its relation to immunity and infectious disease. J Nutr 131(2S–2):616S–633S; discussion 633S-635SPubMedGoogle Scholar
  89. Pae M, Meydani SN, Wu D (2012) The role of nutrition in enhancing immunity in aging. Aging Dis 3(1):91–129PubMedGoogle Scholar
  90. Pallast EG, Schouten EG, de Waart FG et al (1999) Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr 69(6):1273–1281PubMedGoogle Scholar
  91. Parker BA, Chapman IM (2004) Food intake and ageing–the role of the gut. Mech Ageing Dev 125(12):859–866PubMedCrossRefGoogle Scholar
  92. Pekmezci D (2011) Vitamin E and immunity. Vitam Horm 86:179–215PubMedCrossRefGoogle Scholar
  93. Pepersack T (2009) Nutritional problems in the elderly. Acta Clin Belg 64(2):85–91PubMedGoogle Scholar
  94. Pokorny AD, Miller BA, Kaplan HB (1972) The brief MAST: a shortened version of the Michigan Alcoholism Screening Test. Am J Psychiatry 129(3):342–345PubMedGoogle Scholar
  95. Price DM (2008) Protein-energy malnutrition among the elderly: implications for nursing care. Holist Nurs Pract 22(6):355–360PubMedCrossRefGoogle Scholar
  96. Rall LC, Meydani SN (1993) Vitamin B6 and immune competence. Nutr Rev 51(8):217–225PubMedCrossRefGoogle Scholar
  97. Redmond HP, Leon P, Lieberman MD et al (1991) Impaired macrophage function in severe protein-energy malnutrition. Arch Surg 126(2):192–196PubMedCrossRefGoogle Scholar
  98. Redmond HP, Gallagher HJ, Shou J et al (1995) Antigen presentation in protein-energy malnutrition. Cell Immunol 163(1):80–87PubMedCrossRefGoogle Scholar
  99. Reibnegger G, Huber LA, Jurgens G et al (1988) Approach to define “normal aging” in man. Immune function, serum lipids, lipoproteins and neopterin levels. Mech Ageing Dev 46(1–3):67–82PubMedCrossRefGoogle Scholar
  100. Rink L, Kirchner H (2000) Zinc-altered immune function and cytokine production. J Nutr 130(5S Suppl):1407S–1411SPubMedGoogle Scholar
  101. Roberts-Thomson IC, Whittingham S, Youngchaiyud U et al (1974) Ageing, immune response, and mortality. Lancet 2(7877):368–370PubMedCrossRefGoogle Scholar
  102. Rothschild MA, Oratz M, Schreiber SS (1972a) Albumin synthesis (second of two parts). N Engl J Med 286(15):816–821PubMedCrossRefGoogle Scholar
  103. Rothschild MA, Oratz M, Schreiber SS (1972b) Albumin synthesis. 1. N Engl J Med 286(14):748–757PubMedCrossRefGoogle Scholar
  104. Roubenoff R (2000) Sarcopenia and its implications for the elderly. Eur J Clin Nutr 54(Suppl 3):S40–S47PubMedCrossRefGoogle Scholar
  105. Ryan-Harshman M, Aldoori W (2005) The relevance of selenium to immunity, cancer, and infectious/inflammatory diseases. Can J Diet Pract Res 66(2):98–102PubMedCrossRefGoogle Scholar
  106. Rymkiewicz PD, Heng YX, Vasudev A et al (2012) The immune system in the aging human. Immunol Res 53(1–3):235–250PubMedCrossRefGoogle Scholar
  107. Satyaraj E (2011) Emerging paradigms in immunonutrition. Top Companion Anim Med 26(1):25–32PubMedCrossRefGoogle Scholar
  108. Savino W, Dardenne M (2010) Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responses. Proc Nutr Soc 69(4):636–643PubMedCrossRefGoogle Scholar
  109. Savino W, Dardenne M, Velloso LA et al (2007) The thymus is a common target in malnutrition and infection. Br J Nutr 98(Suppl 1):S11–S16PubMedGoogle Scholar
  110. Scrimshaw NS, SanGiovanni JP (1997) Synergism of nutrition, infection, and immunity: an overview. Am J Clin Nutr 66(2):464S–477SPubMedGoogle Scholar
  111. Shaikh SR, Edidin M (2006) Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation. Am J Clin Nutr 84(6):1277–1289PubMedGoogle Scholar
  112. Shatenstein B (2008) Impact of health conditions on food intakes among older adults. J Nutr Elder 27(3–4):333–361PubMedCrossRefGoogle Scholar
  113. Shepherd A (2009) Nutrition through the life span. Part 3: adults aged 65 years and over. Br J Nurs 18(5):301–302, 304–307PubMedGoogle Scholar
  114. Sijben JW, Calder PC (2007) Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Proc Nutr Soc 66(2):237–259PubMedCrossRefGoogle Scholar
  115. Smith FR, Goodman DS (1971) The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma. J Clin Invest 50(11):2426–2436PubMedCrossRefGoogle Scholar
  116. Swartz MH (2001) Textbook of physical diagnosis: history and examination, 4th edn. Saunders, PhiladelphiaGoogle Scholar
  117. Tamura J, Kubota K, Murakami H et al (1999) Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol 116(1):28–32PubMedCrossRefGoogle Scholar
  118. Taylor AK, Cao W, Vora KP et al (2013) Protein energy malnutrition decreases immunity and increases susceptibility to influenza infection in mice. J Infect Dis 207(3):501–510PubMedCrossRefGoogle Scholar
  119. Thomson WM, Brown RH, Williams SM (1992) Dentures, prosthetic treatment needs, and mucosal health in an institutionalised elderly population. N Z Dent J 88(392):51–55PubMedGoogle Scholar
  120. Troen AM, Mitchell B, Sorensen B et al (2006) Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 136(1):189–194PubMedGoogle Scholar
  121. Tsai YT, Cheng PC, Fan CK et al (2008) Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101. Int J Food Microbiol 128(2):219–225PubMedCrossRefGoogle Scholar
  122. Vellas B, Lauque S, Andrieu S et al (2001) Nutrition assessment in the elderly. Curr Opin Clin Nutr Metab Care 4(1):5–8PubMedCrossRefGoogle Scholar
  123. Volkert D (2002) Malnutrition in the elderly — prevalence, causes and corrective strategies. Clin Nutr 21(1):110–112CrossRefGoogle Scholar
  124. Volkert D, Saeglitz C, Gueldenzoph H et al (2010) Undiagnosed malnutrition and nutrition-related problems in geriatric patients. J Nutr Health Aging 14(5):387–392PubMedCrossRefGoogle Scholar
  125. Wahrburg U (2004) What are the health effects of fat? Eur J Nutr 43(Suppl 1):I/6–I/11Google Scholar
  126. Weiss G (2002) Iron and immunity: a double-edged sword. Eur J Clin Invest 32(Suppl 1):70–78PubMedCrossRefGoogle Scholar
  127. Weiss G (2004) Chapter 11. Iron. In: Hughes DA, Darlington LG, Bendich A (eds) Diet and human immune function. Humana Press, New YorkGoogle Scholar
  128. Weksler ME (1995) Immune senescence: deficiency or dysregulation. Nutr Rev 53(4 Pt 2):S3–S7PubMedGoogle Scholar
  129. White JV (1991) Risk factors for poor nutritional status in older Americans. Am Fam Physician 44(6):2087–2097PubMedGoogle Scholar
  130. Wilson MM, Morley JE (2003) Invited review: aging and energy balance. J Appl Physiol 95(4):1728–1736PubMedGoogle Scholar
  131. Wintergerst ES, Maggini S, Hornig DH (2006) Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab 50(2):85–94PubMedCrossRefGoogle Scholar
  132. Wu D, Meydani SN (2008) Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol 84(4):900–914PubMedCrossRefGoogle Scholar
  133. Yesavage JA, Brink TL, Rose TL et al (1982) Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17(1):37–49PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Armin Hirbod-Mobarakeh
    • 1
  • Maryam Mahmoudi
    • 2
    Email author
  • Nima Rezaei
    • 1
    • 3
    • 4
  1. 1.Molecular Immunology Research CenterTehran University of Medical SciencesTehranIran
  2. 2.School of Nutrition and DieteticsTehran University of Medical SciencesTehranIran
  3. 3.Research Center for Immunodeficiencies, Children’s Medical CenterTehranIran
  4. 4.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran

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