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The Immune System, a Marker and Modulator of the Rate of Aging

  • Monica De la FuenteEmail author
Chapter

Abstract

The ageing process shows heterogeneity in the changes suffered by each physiological system in the diverse members of a population of the same chronological age. This phenomenon led to the concept of “biological ageing,” which determines the rate of ageing experienced by each individual and therefore his/her life quality and expectancy. Since the biological age of a subject is difficult to measure, it is necessary to find markers, which will make it possible. The functional capacity of immune cells has been proposed as a marker of health, and using mice with premature senescence, long-lived mice, and human centenarians, it has been confirmed that several immune functions are good markers of biological age and predictors of longevity. Moreover, we have proposed the oxidation-inflammation theory of ageing, in which the immune system is involved in the rate of oxi-inflamm-ageing of the organism and in the biological age. This has been confirmed that applying several lifestyle strategies improves the immune cell functions, decreases oxidative stress, improves the general health, and consequently increases longevity in elderly.

Keywords

Immune Cell Immune Function Aging Process Caloric Restriction Environmental Enrichment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The author thanks Mr. D. Potter for his help with the English language revision of the manuscript and also expresses her gratitude to Dr. Ortega, Dr. Vallejo, Dr. Medina, Dr. Victor, Dr. Alvarado, Dr. Alvarez, Dr. Alonso, Dr. Arranz, Dr. Baeza, Dr, Gimenez-Llort, Ms De Castro, Ms Vida, Ms Hernandez, Ms Cruces, and Ms Maté for their invaluable help in performing several of the experiments which have allowed us to arrive at the ideas expressed in this chapter. This work was supported by grants of the MINECO (BFU2011-03336), Research Group of UCM (910379ENEROINN), and RETICEF (RD06/0013/0003) (RD12/0043/0018)(ISCIII-FEDER of the European Union).

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Physiology, Faculty of BiologyComplutense University of MadridMadridSpain

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