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Influenza Infection in the Elderly

  • Kasra Moazzami
  • Janet E. McElhaney
  • Nima RezaeiEmail author
Chapter

Abstract

Influenza is a febrile respiratory disease, which is usually associated with a mild acute self-limited illness. However, certain risk factors, including ageing, are associated with severity of disease and the occurrence of influenza-related complications. Influenza infection has shown to be foremost among all infectious diseases in its association with an age-related increase in the incidence of serious complications. A decrease in immune function is a hallmark of ageing that imposes negative effects in its ability to resist influenza virus infection and its response to vaccination. It has been recognized that the ageing process affects both branches of the immune system, namely, the innate and adaptive immune systems.

Keywords

Major Histocompatibility Complex Natural Killer Cell Influenza Vaccine Influenza Vaccination Influenza Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Kasra Moazzami
    • 1
  • Janet E. McElhaney
    • 2
  • Nima Rezaei
    • 3
    • 4
    • 5
    Email author
  1. 1.Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical SchoolCharlestownUSA
  2. 2.Vancouver Coastal Health Research InstituteUniversity of British ColumbiaVancouverCanada
  3. 3.Research Center for Immunodeficiencies, Children’s Medical CenterTehran University of Medical SciencesTehranIran
  4. 4.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran
  5. 5.Molecular Immunology Research CenterTehran University of Medical SciencesTehranIran

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