Aging Immunity and Infection

  • Mehdi ShekarabiEmail author
  • Fatemeh Asgari


Immunosenescence is an age-related malfunction of the immune system, which could be accompanied by an increased susceptibility to infections. Many infections occur more common in older individuals and it could be associated with higher morbidity and mortality. During senescence, physiological condition provides situation that causative agents causing infection change, and there is a shift in organisms involved during infection and comorbidies of infection with greater diversity are more common than those occurred in younger adults. Increased risks and acquiring many types of infections with severe clinical outcome occurred in part due to impairment of immune defenses that might be aggravated by chronic infections, malnutrition, and prolonged medication received during ageing.


Chronic Obstructive Pulmonary Disease Respiratory Syncytial Virus Bacterial Meningitis Varicella Zoster Virus Lower Respiratory Tract Infection 
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  1. Avelino-Silva VI, Ho YL, Avelino-Silva TJ et al (2011) Aging and HIV infection. Ageing Res Rev 10(1):163–172PubMedCrossRefGoogle Scholar
  2. Buchholz VR, Neuenhahn M, Busch DH (2011) CD8<sup>+</sup>T cell differentiation in the aging immune system: until the last clone standing. Curr Opin Immunol 23(4):549–554PubMedCrossRefGoogle Scholar
  3. Caruso C, Buffa S, Candore G et al (2009) Mechanisms of immunosenescence. Immun Ageing 6(10)Google Scholar
  4. Choi C (2001) Bacterial meningitis in aging adults. Clin infect dis 33(8):1380–1385PubMedCrossRefGoogle Scholar
  5. Effros RB (2007) Role of T lymphocyte replicative senescence in vaccine efficacy. Vaccine 25(4):599–604PubMedCrossRefGoogle Scholar
  6. Gomez CR, Nomellini V, Faunce DE et al (2008) Innate immunity and aging. Exp Gerontol 43(8):718–728PubMedCrossRefGoogle Scholar
  7. Meyer KC (2001) The role of immunity in susceptibility to respiratory infection in the aging lung. Respir Physiol 128(1):23PubMedCrossRefGoogle Scholar
  8. Ogra PL (2010) Ageing and its possible impact on mucosal immune responses. Ageing Res Rev 9(2):101–106PubMedCrossRefGoogle Scholar
  9. Tiihonen K, Ouwehand AC, Rautonen N (2010) Human intestinal microbiota and healthy ageing. Ageing Res Rev 9(2):107PubMedCrossRefGoogle Scholar
  10. Yoshikawa T, Norman D (2009) Infectious disease in the aging: a clinical handbook. Humana Press, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Immunology, School of MedicineIran University of Medical SciencesTehranIran

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