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Immunogenetics of Aging

  • Ali Akbar AmirzargarEmail author
Chapter

Abstract

The importance of environment, genetics, and stochasticity factors are changed with longevity. It is well documented that the quality and the size of the humoral immune response decline with age. The individuals, genetically enriched for longevity, possess different immune signatures comparing to the general population. Human leukocyte antigen and cytokine gene polymorphisms are two examples with some associations with ageing. The genetic factors coding the immune system in association with ageing have been described in this chapter.

Keywords

Human Leukocyte Antigen Successful Aging Young Control C282Y Mutation Cytokine Gene Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Abbott A (2004) Ageing: growing old gracefully. Nature 428(6979):116–118PubMedCrossRefGoogle Scholar
  2. Amanzadeh A, Amirzargar AA, Mohseni N et al (2012) Association of HLA-DRB1, DQA1 and DQB1 alleles and haplotypes with common variable immunodeficiency in Iranian patients. Avicenna J Med Biotechnol 4(2):103–112PubMedGoogle Scholar
  3. Amirzargar A, Mytilineos J, Yousefipour A et al (1998) HLA class II (DRB1, DQA1 and DQB1) associated genetic susceptibility in Iranian multiple sclerosis (MS) patients. Eur J Immunogenet 25(4):297–301PubMedCrossRefGoogle Scholar
  4. Amirzargar AA, Yalda A, Hajabolbaghi M et al (2004) The association of HLA-DRB, DQA1, DQB1 alleles and haplotype frequency in Iranian patients with pulmonary tuberculosis. Int J Tuberc Lung Dis 8(8):1017–1021PubMedGoogle Scholar
  5. Amirzargar AA, Bagheri M, Ghavamzadeh A et al (2005a) Cytokine gene polymorphism in Iranian patients with chronic myelogenous leukaemia. Int J Immunogenet 32(3):167–171PubMedCrossRefGoogle Scholar
  6. Amirzargar AA, Tabasi A, Khosravi F et al (2005b) Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 4-year follow-up study. Eur J Neurol 12(1):25–30PubMedCrossRefGoogle Scholar
  7. Amirzargar AA, Rezaei N, Jabbari H et al (2006) Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis. Eur Cytokine Netw 17(2):84–89PubMedGoogle Scholar
  8. Amirzargar AA, Khosravi F, Dianat SS et al (2007) Association of HLA class II allele and haplotype frequencies with chronic myelogenous leukemia and age-at-onset of the disease. Pathol Oncol Res 13(1):47–51PubMedCrossRefGoogle Scholar
  9. Amirzargar AA, Mohseni N, Shokrgozar MA et al (2008) HLA-DRB1, DQA1 and DQB1 alleles and haplotypes frequencies in Iranian healthy adult responders and non-responders to recombinant hepatitis B vaccine. Iran J Immunol 5(2):92–99PubMedGoogle Scholar
  10. Amirzargar AA, Movahedi M, Rezaei N et al (2009) Polymorphisms in IL4 and iLARA confer susceptibility to asthma. J Investig Allergol Clin Immunol 19(6):433–438PubMedGoogle Scholar
  11. Anvari M, Khalilzadeh O, Esteghamati A et al (2010) Graves’ disease and gene polymorphism of TNF-alpha, IL-2, IL-6, IL-12, and IFN-gamma. Endocrine 37(2):344–348PubMedCrossRefGoogle Scholar
  12. Barkhordari E, Rezaei N, Mahmoudi M et al (2010) T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome. Inflammation 33(5):281–286PubMedCrossRefGoogle Scholar
  13. Behniafard N, Gharagozlou M, Farhadi E et al (2012) TNF-alpha single nucleotide polymorphisms in atopic dermatitis. Eur Cytokine Netw 23(4):163–165PubMedGoogle Scholar
  14. Beutler E (2007) Iron storage disease: facts, fiction and progress. Blood Cells Mol Dis 39(2):140–147PubMedCrossRefGoogle Scholar
  15. Bruunsgaard H, Andersen-Ranberg K, Hjelmborg J et al (2003a) Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med 115(4):278–283PubMedCrossRefGoogle Scholar
  16. Bruunsgaard H, Ladelund S, Pedersen AN et al (2003b) Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clin Exp Immunol 132(1):24–31PubMedCrossRefGoogle Scholar
  17. Bulati M, Buffa S, Candore G et al (2011) B cells and immunosenescence: a focus on IgG+IgD-CD27- (DN) B cells in aged humans. Ageing Res Rev 10(2):274–284PubMedCrossRefGoogle Scholar
  18. Candore G, Lio D, Colonna RG et al (2002) Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions. Autoimmun Rev 1(1–2):29–35PubMedCrossRefGoogle Scholar
  19. Candore G, Modica MA, Lio D et al (2003) Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: a genetically determined defect of C4 influences immunological parameters of healthy carriers of the haplotype. Biomed Pharmacother 57(7):274–277PubMedCrossRefGoogle Scholar
  20. Candore G, Balistreri CR, Grimaldi MP et al (2006) Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population. Ann N Y Acad Sci 1067:270–275PubMedCrossRefGoogle Scholar
  21. Capri M, Salvioli S, Sevini F et al (2006) The genetics of human longevity. Ann N Y Acad Sci 1067:252–263PubMedCrossRefGoogle Scholar
  22. Carrieri G, Marzi E, Olivieri F et al (2004) The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell 3(6):443–448PubMedCrossRefGoogle Scholar
  23. Caruso C, Candore G, Colonna Romano G et al (2000) HLA, aging, and longevity: a critical reappraisal. Hum Immunol 61(9):942–949PubMedCrossRefGoogle Scholar
  24. Caruso C, Candore G, Romano GC et al (2001) Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data. Mech Ageing Dev 122(5):445–462PubMedCrossRefGoogle Scholar
  25. Cesari M, Penninx BW, Pahor M et al (2004) Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 59(3):242–248PubMedCrossRefGoogle Scholar
  26. Cevenini E, Bellavista E, Tieri P et al (2010) Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies. Curr Pharm Des 16(7):802–813PubMedCrossRefGoogle Scholar
  27. Colonna-Romano G, Buffa S, Bulati M et al (2010) B cells compartment in centenarian offspring and old people. Curr Pharm Des 16(6):604–608PubMedCrossRefGoogle Scholar
  28. Davoudi S, Amirzargar AA, Hajiabdolbaghi M et al (2006) Th-1 cytokines gene polymorphism in human brucellosis. Int J Immunogenet 33(5):355–359PubMedCrossRefGoogle Scholar
  29. De Benedictis G, Franceschi C (2006) The unusual genetics of human longevity. Sci Aging Knowledge Environ 2006(10):pe20PubMedCrossRefGoogle Scholar
  30. De Benedictis G, Rose G, Carrieri G et al (1999) Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J 13(12):1532–1536PubMedGoogle Scholar
  31. Dehaghani AS, Amirzargar A, Farjadian S et al (2002) HLA-DQBl alleles and susceptibility to cervical squamous cell carcinoma in Southern Iranian patients. Pathol Oncol Res 8(1):58–61PubMedCrossRefGoogle Scholar
  32. Derhovanessian E, Maier AB, Beck R et al (2010) Hallmark features of immunosenescence are absent in familial longevity. J Immunol 185(8):4618–4624PubMedCrossRefGoogle Scholar
  33. Ferrucci L, Harris TB, Guralnik JM et al (1999) Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc 47(6):639–646PubMedGoogle Scholar
  34. Fraga MF, Ballestar E, Paz MF et al (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102(30):10604–10609PubMedCrossRefGoogle Scholar
  35. Franceschi C, Motta L, Valensin S et al (2000) Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE). Aging (Milano) 12(2):77–84Google Scholar
  36. Franceschi C, Motta L, Motta M et al (2008) The extreme longevity: the state of the art in Italy. Exp Gerontol 43(2):45–52PubMedCrossRefGoogle Scholar
  37. Ghaderi A, Talei A, Gharesi-Fard B et al (2001) HLA-DBR 1 alleles and the susceptibility of Iranian patients with breast cancer. Pathol Oncol Res 7(1):39–41PubMedCrossRefGoogle Scholar
  38. Henon N, Busson M, Dehay-Martuchou C et al (1999) Familial versus sporadic longevity and MHC markers. J Biol Regul Homeost Agents 13(1):27–31PubMedGoogle Scholar
  39. Hojjat-Farsangi M, Jeddi-Tehrani M, Amirzargar AA et al (2008) Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia. Hum Immunol 69(10):666–674PubMedCrossRefGoogle Scholar
  40. Iannitti T, Palmieri B (2011) Inflammation and genetics: an insight in the centenarian model. Hum Biol 83(4):531–559PubMedCrossRefGoogle Scholar
  41. Ivanova R, Henon N, Lepage V et al (1998) HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. Hum Mol Genet 7(2):187–194PubMedCrossRefGoogle Scholar
  42. Izaks GJ, van Houwelingen HC, Schreuder GM et al (1997) The association between human leucocyte antigens (HLA) and mortality in community residents aged 85 and older. J Am Geriatr Soc 45(1):56–60PubMedGoogle Scholar
  43. Izaks GJ, Remarque EJ, Schreuder GM et al (2000) The effect of geographic origin on the frequency of HLA antigens and their association with ageing. Eur J Immunogenet 27(2):87–92PubMedCrossRefGoogle Scholar
  44. Khalilzadeh O, Anvari M, Esteghamati A et al (2010) Genetic susceptibility to Graves’ ophthalmopathy: the role of polymorphisms in anti-inflammatory cytokine genes. Ophthalmic Genet 31(4):215–220PubMedCrossRefGoogle Scholar
  45. Khosravi F, Amirzargar A, Sarafnejad A et al (2007) HLA class II allele and haplotype frequencies in Iranian patients with leukemia. Iran J Allergy Asthma Immunol 6(3):137–142PubMedGoogle Scholar
  46. Klein SL (2000) The effects of hormones on sex differences in infection: from genes to behavior. Neurosci Biobehav Rev 24(6):627–638PubMedCrossRefGoogle Scholar
  47. Lagaay AM, D’Amaro J, Ligthart GJ et al (1991) Longevity and heredity in humans. Association with the human leucocyte antigen phenotype. Ann N Y Acad Sci 621:78–89PubMedCrossRefGoogle Scholar
  48. Letizia Scola, Domenico Lio a, Giuseppina Candore (2008) Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians. Experimental Gerontology 43 114–118.Google Scholar
  49. Lio D, Balistreri CR, Colonna-Romano G et al (2002a) Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population. Genes Immun 3(1):20–24PubMedCrossRefGoogle Scholar
  50. Lio D, Scola L, Crivello A et al (2002b) Allele frequencies of +874T–>A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. Exp Gerontol 37(2–3):315–319PubMedCrossRefGoogle Scholar
  51. Lio D, Scola L, Crivello A et al (2002c) Gender-specific association between −1082 IL-10 promoter polymorphism and longevity. Genes Immun 3(1):30–33PubMedCrossRefGoogle Scholar
  52. Lio D, Pes GM, Carru C et al (2003a) Association between the HLA-DR alleles and longevity: a study in Sardinian population. Exp Gerontol 38(3):313–317PubMedCrossRefGoogle Scholar
  53. Lio D, Scola L, Crivello A et al (2003b) Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 –1082 promoter SNP and its interaction with TNF-alpha −308 promoter SNP. J Med Genet 40(4):296–299PubMedCrossRefGoogle Scholar
  54. Lio D, Candore G, Crivello A et al (2004) Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. J Med Genet 41(10):790–794PubMedCrossRefGoogle Scholar
  55. Mahmoodi M, Nahvi H, Mahmoudi M et al (2012) HLA-DRB1,-DQA1 and -DQB1 allele and haplotype frequencies in female patients with early onset breast cancer. Pathol Oncol Res 18(1):49–55PubMedCrossRefGoogle Scholar
  56. Mahmoudi M, Amirzargar AA, Jamshidi AR et al (2011) Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis. Eur Cytokine Netw 22(4):175–180PubMedGoogle Scholar
  57. Mendelsohn ME, Karas RH (1999) The protective effects of estrogen on the cardiovascular system. N Engl J Med 340(23):1801–1811PubMedCrossRefGoogle Scholar
  58. Miriam Capri, Stefano Salvioli, Federica Sevini, Silvana Valensin, Laura Celani, Daniela Monti, Graham Pawelec, Giovanna De Benedictis, E Efstathios S. Gonos, and Claudio Francesch (2006) The Genetics of Human Longevity. Ann. N.Y. Acad. Sci, 1067: 252–263Google Scholar
  59. Mirahmadian M, Kalantar F, Heidari G et al (2008) Association of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in Iranian patients with pre-eclampsia. Am J Reprod Immunol 60(2):179–185PubMedCrossRefGoogle Scholar
  60. Moazzeni SM, Amirzargar AA, Shokri F (1999) HLA antigens in Iranian patients with B-cell chronic lymphocytic leukemia. Pathol Oncol Res 5(2):142–145PubMedCrossRefGoogle Scholar
  61. Mohammadi J, Pourpak Z, Jarefors S et al (2008) Human leukocyte antigens (HLA) associated with selective IgA deficiency in Iran and Sweden. Iran J Allergy Asthma Immunol 7(4):209–214PubMedGoogle Scholar
  62. Mortazavi H, Amirzargar AA, Esmaili N et al (2013) Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus vulgaris. J Dermatol 40(4):244–248PubMedCrossRefGoogle Scholar
  63. Movahedi M, Moin M, Gharagozlou M et al (2008) Association of HLA class II alleles with childhood asthma and Total IgE levels. Iran J Allergy Asthma Immunol 7(4):215–220PubMedGoogle Scholar
  64. Naumova E, Ivanova M, Pawelec G et al (2011) ‘Immunogenetics of Aging’: report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop. Tissue Antigens 77(3):187–192PubMedCrossRefGoogle Scholar
  65. Nicknam MH, Mahmoudi M, Amirzargar AA et al (2008) Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis. Iran J Allergy Asthma Immunol 7(1):19–24PubMedGoogle Scholar
  66. Okayama N, Hamanaka Y, Suehiro Y et al (2005) Association of interleukin-10 promoter single nucleotide polymorphisms −819 T/C and −592 A/C with aging. J Gerontol A Biol Sci Med Sci 60(12):1525–1529PubMedCrossRefGoogle Scholar
  67. Olivieri F, Bonafe M, Cavallone L et al (2002) The −174 C/G locus affects in vitro/in vivo IL-6 production during aging. Exp Gerontol 37(2–3):309–314PubMedCrossRefGoogle Scholar
  68. Ostan R, Bucci L, Capri M et al (2008) Immunosenescence and immunogenetics of human longevity. Neuroimmunomodulation 15(4–6):224–240PubMedCrossRefGoogle Scholar
  69. Papasteriades C, Boki K, Pappa H et al (1997) HLA phenotypes in healthy aged subjects. Gerontology 43(3):176–181PubMedCrossRefGoogle Scholar
  70. Pietrangelo A (2010) Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment. Gastroenterology 139(2):393–408PubMedCrossRefGoogle Scholar
  71. Proust J, Moulias R, Fumeron F et al (1982) HLA and longevity. Tissue Antigens 19(3):168–173PubMedCrossRefGoogle Scholar
  72. Rabbani A, Abbasi F, Taghvaei M et al (2012) HLA-DRB, -DQA, and DQB alleles and haplotypes in Iranian patients with diabetes mellitus type I. Pediatr Diabetes. doi: 10.1111/j.1399-5448.2012.00869.x PubMedGoogle Scholar
  73. Rea IM, Middleton D (1994) Is the phenotypic combination A1B8Cw7DR3 a marker for male longevity? J Am Geriatr Soc 42(9):978–983PubMedGoogle Scholar
  74. Rezaei N, Aghamohammadi A, Shakiba Y et al (2009) Cytokine gene polymorphisms in common variable immunodeficiency. Int Arch Allergy Immunol 150(1):1–7PubMedCrossRefGoogle Scholar
  75. Roberts CW, Walker W, Alexander J (2001) Sex-associated hormones and immunity to protozoan parasites. Clin Microbiol Rev 14(3):476–488PubMedCrossRefGoogle Scholar
  76. Ross OA, Curran MD, Rea IM et al (2003) HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish. Mech Ageing Dev 124(4):563–567PubMedCrossRefGoogle Scholar
  77. Salvioli S, Olivieri F, Marchegiani F et al (2006) Genes, ageing and longevity in humans: problems, advantages and perspectives. Free Radic Res 40(12):1303–1323PubMedCrossRefGoogle Scholar
  78. Sanjabi S, Zenewicz LA, Kamanaka M et al (2009) Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol 9(4):447–453PubMedCrossRefGoogle Scholar
  79. Sarafnejad A, Khosravi F, Alimoghadam K et al (2006) HLA class II allele and haplotype frequencies in Iranian patients with acute myelogenous leukemia and control group. Iran J Allergy Asthma Immunol 5(3):115–119PubMedGoogle Scholar
  80. Scola L, Lio D, Candore G et al (2008) Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians. Exp Gerontol 43(2):114–118PubMedCrossRefGoogle Scholar
  81. Shahram F, Nikoopour E, Rezaei N et al (2011) Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet’s disease. Clin Exp Rheumatol 29(4 Suppl 67):S28–S31PubMedGoogle Scholar
  82. Shams S, Amirzargar AA, Yousefi M et al (2009) HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris. J Clin Immunol 29(2):175–179PubMedCrossRefGoogle Scholar
  83. Shokrgozar MA, Sarial S, Amirzargar A et al (2009) IL-2, IFN-gamma, and IL-12 gene polymorphisms and susceptibility to multiple sclerosis. J Clin Immunol 29(6):747–751PubMedCrossRefGoogle Scholar
  84. Sonya Vasto, Eugenio Mocchegiani, Giuseppina Candore (2006) Florinda Listi etal Inflammation, genes and zinc in ageing and age-related diseases Biogerontology 7:315–327.Google Scholar
  85. Takata H, Suzuki M, Ishii T et al (1987) Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians. Lancet 2(8563):824–826PubMedCrossRefGoogle Scholar
  86. Terry DF, McCormick M, Andersen S, Pennington J, Schoenhofen E, Palaima E, Bausero M, Ogawa K, Perls TT (2004) Asea A: Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann N Y Acad Sci, 1019:502–505.PubMedCrossRefGoogle Scholar
  87. Vasto S, Mocchegiani E, Candore G et al (2006) Inflammation, genes and zinc in ageing and age-related diseases. Biogerontology 7(5–6):315–327PubMedCrossRefGoogle Scholar
  88. Vaupel JW, Carey JR, Christensen K et al (1998) Biodemographic trajectories of longevity. Science 280(5365):855–860PubMedCrossRefGoogle Scholar
  89. Vina J, Borras C, Gambini J et al (2005) Why females live longer than males: control of longevity by sex hormones. Sci Aging Knowledge Environ 2005(23):pe17PubMedCrossRefGoogle Scholar
  90. Weidemann W, Hanke H (2002) Cardiovascular effects of androgens. Cardiovasc Drug Rev 20(3):175–198PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Molecular Immunology Research Center and Departement of ImmunologyTehran University of Medical SciencesTehranIran

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