Immunogenetics of Aging

  • Ali Akbar AmirzargarEmail author


The importance of environment, genetics, and stochasticity factors are changed with longevity. It is well documented that the quality and the size of the humoral immune response decline with age. The individuals, genetically enriched for longevity, possess different immune signatures comparing to the general population. Human leukocyte antigen and cytokine gene polymorphisms are two examples with some associations with ageing. The genetic factors coding the immune system in association with ageing have been described in this chapter.


Human Leukocyte Antigen Successful Aging Young Control C282Y Mutation Cytokine Gene Polymorphism 
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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Molecular Immunology Research Center and Departement of ImmunologyTehran University of Medical SciencesTehranIran

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