The Role of MicroRNAs in Immunosenescence Process

  • Seyed Hossein Aalaei-andabili
  • Alireza Zare-Bidoki
  • Nima RezaeiEmail author


Genetic factors play important roles in ageing process. The aged cells accumulate in senescing tissues and organs and lead to age-associated disorders. It has recently been recognized that proteins and genes involving in ageing process are precisely regulated by various MicroRNAs. MicroRNAs have been understood as pathway regulators in biological processes such as immune system component development and activation. MicroRNAs have crucial regulatory roles in development of hematopoietic lineage, maturation and differentiation of B and T lymphocytes, proliferation of neutrophils and monocytes, secretion of type 1 interferon and proinflammatory cytokines/chemokine, and effectiveness of immune system response. These emerging evidences indicate importance of MicroRNAs in controlling functions of the immune system and immunosenescence regulation.


Human Umbilical Vein Endothelial Cell MiRs Expression Aged Mouse Young Mouse Triple Negative 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Seyed Hossein Aalaei-andabili
    • 1
  • Alireza Zare-Bidoki
    • 2
  • Nima Rezaei
    • 3
    • 2
    • 4
    Email author
  1. 1.Research Center for Immunodeficiencies, Children’s Medical CenterTehran University of Medical SciencesTehranIran
  2. 2.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran
  3. 3.Molecular Immunology Research CenterTehran University of Medical SciencesTehranIran
  4. 4.Research Center for Immunodeficiencies, Children’s Medical CenterTehranIran

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