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The Role of MicroRNAs in Immunosenescence Process

  • Seyed Hossein Aalaei-andabili
  • Alireza Zare-Bidoki
  • Nima RezaeiEmail author
Chapter

Abstract

Genetic factors play important roles in ageing process. The aged cells accumulate in senescing tissues and organs and lead to age-associated disorders. It has recently been recognized that proteins and genes involving in ageing process are precisely regulated by various MicroRNAs. MicroRNAs have been understood as pathway regulators in biological processes such as immune system component development and activation. MicroRNAs have crucial regulatory roles in development of hematopoietic lineage, maturation and differentiation of B and T lymphocytes, proliferation of neutrophils and monocytes, secretion of type 1 interferon and proinflammatory cytokines/chemokine, and effectiveness of immune system response. These emerging evidences indicate importance of MicroRNAs in controlling functions of the immune system and immunosenescence regulation.

Keywords

Human Umbilical Vein Endothelial Cell MiRs Expression Aged Mouse Young Mouse Triple Negative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4(7):499–511PubMedCrossRefGoogle Scholar
  2. Baker DJ, Wijshake T, Tchkonia T et al (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479(7372):232–236PubMedCrossRefGoogle Scholar
  3. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281–297PubMedCrossRefGoogle Scholar
  4. Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215–233PubMedCrossRefGoogle Scholar
  5. Bhaumik D, Scott GK, Schokrpur S et al (2009) MicroRNAs MiR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging 1(4):402–411PubMedGoogle Scholar
  6. Ceppi M, Pereira PM, Dunand-Sauthier I et al (2009) MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc Natl Acad Sci U S A 106(8):2735–2740PubMedCrossRefGoogle Scholar
  7. Cevenini E, Bellavista E, Tieri P et al (2010) Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies. Curr Pharm Des 16(7):802–813PubMedCrossRefGoogle Scholar
  8. Chassin C, Kocur M, Pott J et al (2010) MiR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe 8(4):358–368PubMedCrossRefGoogle Scholar
  9. Colotta F, Re F, Polentarutti N et al (1992) Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80(8):2012–2020PubMedGoogle Scholar
  10. Coppe JP, Patil CK, Rodier F et al (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6(12):2853–2868PubMedCrossRefGoogle Scholar
  11. Ford-Hutchinson AW, Bray MA, Doig MV et al (1980) Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286(5770):264–265PubMedCrossRefGoogle Scholar
  12. Franceschi C, Bonafe M, Valensin S et al (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244–254PubMedCrossRefGoogle Scholar
  13. Frasca D, Landin AM, Riley RL et al (2008) Mechanisms for decreased function of B cells in aged mice and humans. J Immunol 180(5):2741–2746PubMedGoogle Scholar
  14. Friedman DB, Johnson TE (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118(1):75–86PubMedGoogle Scholar
  15. Godfrey DI, Zlotnik A (1993) Control points in early T-cell development. Immunol Today 14(11):547–553PubMedCrossRefGoogle Scholar
  16. Haslett C (1999) Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med 160(5 Pt 2):S5–S11PubMedCrossRefGoogle Scholar
  17. Jiang M, Xiang Y, Wang D et al (2012) Dysregulated expression of MiR-146a contributes to age-related dysfunction of macrophages. Aging Cell 11(1):29–40PubMedCrossRefGoogle Scholar
  18. Johnnidis JB, Harris MH, Wheeler RT et al (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451(7182):1125–1129PubMedCrossRefGoogle Scholar
  19. Kennedy AD, DeLeo FR (2009) Neutrophil apoptosis and the resolution of infection. Immunol Res 43(1–3):25–61PubMedCrossRefGoogle Scholar
  20. Li L, Hsu HC, Grizzle WE et al (2003) Cellular mechanism of thymic involution. Scand J Immunol 57(5):410–422PubMedCrossRefGoogle Scholar
  21. Liu J (2008) Control of protein synthesis and mRNA degradation by microRNAs. Curr Opin Cell Biol 20(2):214–221PubMedCrossRefGoogle Scholar
  22. Lum JJ, Bren G, McClure R et al (2005) Elimination of senescent neutrophils by TNF-related apoptosis-inducing ligand. J Immunol 175(2):1232–1238PubMedGoogle Scholar
  23. Lysgaard C, Nielsen MS, Christensen JH et al (2012) No effect of high-dose atorvastatin on leukotriene B(4) formation from neutrophils in patients treated with coronary bypass surgery: a randomized placebo-controlled double-blinded trial with a crossover design. Prostaglandins Leukot Essent Fatty Acids 87(6):185–188PubMedCrossRefGoogle Scholar
  24. Martin C, Burdon PC, Bridger G et al (2003) Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity 19(4):583–593PubMedCrossRefGoogle Scholar
  25. Mott JL, Kobayashi S, Bronk SF et al (2007) MiR-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 26(42):6133–6140PubMedCrossRefGoogle Scholar
  26. O’Neill LA, Sheedy FJ, McCoy CE (2011) MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol 11(3):163–175PubMedCrossRefGoogle Scholar
  27. Ohyashiki M, Ohyashiki JH, Hirota A et al (2011) Age-related decrease of MiRNA-92a levels in human CD8+ T-cells correlates with a reduction of naive T lymphocytes. Immun Ageing 8(1):11PubMedCrossRefGoogle Scholar
  28. Olivieri F, Lazzarini R, Recchioni R et al (2012a) MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr). doi: 10.1007/s11357-012-9440-8 Google Scholar
  29. Olivieri F, Spazzafumo L, Santini G et al (2012b) Age-related differences in the expression of circulating microRNAs: MiR-21 as a new circulating marker of inflammaging. Mech Ageing Dev 133(11–12):675–685PubMedCrossRefGoogle Scholar
  30. Rodier F, Coppe JP, Patil CK et al (2009) Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 11(8):973–979PubMedCrossRefGoogle Scholar
  31. Rodriguez A, Vigorito E, Clare S et al (2007) Requirement of bic/microRNA-155 for normal immune function. Science 316(5824):608–611PubMedCrossRefGoogle Scholar
  32. Saccani S, Pantano S, Natoli G (2002) p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol 3(1):69–75PubMedCrossRefGoogle Scholar
  33. Salaun B, Yamamoto T, Badran B et al (2011) Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets. J Transl Med 9:44PubMedCrossRefGoogle Scholar
  34. Scapini P, Lapinet-Vera JA, Gasperini S et al (2000) The neutrophil as a cellular source of chemokines. Immunol Rev 177:195–203PubMedCrossRefGoogle Scholar
  35. Seeger T, Haffez F, Fischer A et al (2013) Immunosenescence-associated microRNAs in age and heart failure. Eur J Heart Fail 15(4):385–393PubMedCrossRefGoogle Scholar
  36. Spazzafumo L, Olivieri F, Abbatecola AM et al (2011) Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes. Age (Dordr) 35(2):419–429CrossRefGoogle Scholar
  37. Taganov KD, Boldin MP, Chang KJ et al (2006) NF-kappa B-dependent induction of microRNA MiR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 103(33):12481–12486PubMedCrossRefGoogle Scholar
  38. Tili E, Michaille JJ, Cimino A et al (2007) Modulation of MiR-155 and MiR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 179(8):5082–5089PubMedGoogle Scholar
  39. Tsang WP, Kwok TT (2008) Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3. Apoptosis 13(10):1215–1222PubMedCrossRefGoogle Scholar
  40. Van Duin D, Mohanty S, Thomas V et al (2007) Age-associated defect in human TLR-1/2 function. J Immunol 178(2):970–975PubMedGoogle Scholar
  41. Ventura A, Young AG, Winslow MM et al (2008) Targeted deletion reveals essential and overlapping functions of the MiR-17 through 92 family of MiRNA clusters. Cell 132(5):875–886PubMedCrossRefGoogle Scholar
  42. Virts EL, Thoman ML (2010) Age-associated changes in MiRNA expression profiles in thymopoiesis. Mech Ageing Dev 131(11–12):743–748PubMedCrossRefGoogle Scholar
  43. Ward JR, Heath PR, Catto JW et al (2011) Regulation of neutrophil senescence by microRNAs. PLoS One 6(1):e15810PubMedCrossRefGoogle Scholar
  44. Whyte MK, Savill J, Meagher LC et al (1997) Coupling of neutrophil apoptosis to recognition by macrophages: coordinated acceleration by protein synthesis inhibitors. J Leukoc Biol 62(2):195–202PubMedGoogle Scholar
  45. Xiao C, Srinivasan L, Calado DP et al (2008) Lymphoproliferative disease and autoimmunity in mice with increased MiR-17-92 expression in lymphocytes. Nat Immunol 9(4):405–414PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Seyed Hossein Aalaei-andabili
    • 1
  • Alireza Zare-Bidoki
    • 2
  • Nima Rezaei
    • 3
    • 2
    • 4
    Email author
  1. 1.Research Center for Immunodeficiencies, Children’s Medical CenterTehran University of Medical SciencesTehranIran
  2. 2.Department of Immunology, School of MedicineTehran University of Medical SciencesTehranIran
  3. 3.Molecular Immunology Research CenterTehran University of Medical SciencesTehranIran
  4. 4.Research Center for Immunodeficiencies, Children’s Medical CenterTehranIran

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