The Role of MicroRNAs in Immunosenescence Process
Genetic factors play important roles in ageing process. The aged cells accumulate in senescing tissues and organs and lead to age-associated disorders. It has recently been recognized that proteins and genes involving in ageing process are precisely regulated by various MicroRNAs. MicroRNAs have been understood as pathway regulators in biological processes such as immune system component development and activation. MicroRNAs have crucial regulatory roles in development of hematopoietic lineage, maturation and differentiation of B and T lymphocytes, proliferation of neutrophils and monocytes, secretion of type 1 interferon and proinflammatory cytokines/chemokine, and effectiveness of immune system response. These emerging evidences indicate importance of MicroRNAs in controlling functions of the immune system and immunosenescence regulation.
KeywordsHuman Umbilical Vein Endothelial Cell MiRs Expression Aged Mouse Young Mouse Triple Negative
- Lysgaard C, Nielsen MS, Christensen JH et al (2012) No effect of high-dose atorvastatin on leukotriene B(4) formation from neutrophils in patients treated with coronary bypass surgery: a randomized placebo-controlled double-blinded trial with a crossover design. Prostaglandins Leukot Essent Fatty Acids 87(6):185–188PubMedCrossRefGoogle Scholar