Effects of Aging on B Cells

  • Mohammad Hossein NicknamEmail author
  • Alireza Rezaiemanesh


B cells and humoral immune response decline in elderly individuals. Age-related changes in B cell commitment and development include decline in frequency of precursors. Recent studies showed a remarkable decline in pre-B cell numbers in aged mice without decrease in the number of mature B cells. This chapter briefly reviewed B cells changes during ageing.


Germinal Center Aged Mouse Young Mouse Class Switch Recombination Affinity Maturation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Mohammad Hossein Nicknam
    • 1
    Email author
  • Alireza Rezaiemanesh
    • 2
  1. 1.Department of Immunology, Molecular Immunology Research CenterTehran University of Medical SciencesTehranIran
  2. 2.Department of ImmunologyTehran University of Medical SciencesTehranIran

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