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Effects of Aging on B Cells

  • Mohammad Hossein NicknamEmail author
  • Alireza Rezaiemanesh
Chapter

Abstract

B cells and humoral immune response decline in elderly individuals. Age-related changes in B cell commitment and development include decline in frequency of precursors. Recent studies showed a remarkable decline in pre-B cell numbers in aged mice without decrease in the number of mature B cells. This chapter briefly reviewed B cells changes during ageing.

Keywords

Germinal Center Aged Mouse Young Mouse Class Switch Recombination Affinity Maturation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Mohammad Hossein Nicknam
    • 1
    Email author
  • Alireza Rezaiemanesh
    • 2
  1. 1.Department of Immunology, Molecular Immunology Research CenterTehran University of Medical SciencesTehranIran
  2. 2.Department of ImmunologyTehran University of Medical SciencesTehranIran

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