Age-Related Alterations in Regulatory T Cells

  • Amir Hossein MassoudEmail author


Age-associated impaired function of the immune system seems to be a major contributory factor to the increased frequency of morbidity and mortality. Ageing affects different immune cell types, including hematopoietic stem cells, lymphoid progenitors in the bone marrow and thymus, thymic stromal cells, mature lymphocytes in secondary lymphoid organs, and elements of the innate immune system. Importantly, significant alterations are seen in the T lymphocyte compartment. Age-related alterations are evident in all stages of the T cell development making them a significant element in immunosenescence. Recent studies showed that T regulatory cells, a subset of CD4+ T cells with immunoregulatory activities, are also affected by ageing. The age-related alterations of Tregs, mechanisms underlying Treg homeostasis, and functions in ageing are described in this chapter.


Treg Cell Aged Mouse Young Counterpart Secondary Lymphoid Organ Peripheral Tolerance 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyMcGill UniversityMontrealCanada
  2. 2.Meakins-Christie LaboratoriesMcGill UniversityMontrealCanada

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